Due to the current fast-paced business environment, new approaches to product development (PD) have been requested. In that matter, the agile approach has gained interest among researchers and practitioners. Based on its positive results in the software industry, it has started to be adopted in the manufacturing industry. Nevertheless, there are factors that manufacturing companies must consider w

Denna artikel har som syfte att förstå hur anställda upplever att relationerna till kollegorna förändrades när de blev förhindrade att mötas fysiskt i det påtvingade distansarbetet under coronapandemin. Studien baseras på djupintervjuer med anställda inom kunskapsintensiva yrken. Resultatet visar på (i) färre kontakter, (ii) minskad tillgänglighet och (iii) försvagad dynamik mellan kollegor. Sluts

It is unclear whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration predict brain atrophy in cognitively healthy older adults, whether these associations can be explained by phosphorylated tau181 (p-tau) and the 42 amino acid form of amyloid-β (Aβ42) biomarkers, and which neural substrates may drive these associations. We addressed these questions in 2 samples of cognitively healthy ol

Evolutionary biology is paying increasing attention to the mechanisms that enable phenotypic plasticity, evolvability, and extra-genetic inheritance. Yet, there is a concern that these phenomena remain insufficiently integrated within evolutionary theory. Understanding their evolutionary implications would require focusing on phenotypes and their variation, but this does not always fit well with t

The total cross section and differential cross sections for the production of Bc± mesons, times their branching fraction to J/ψπ±, are measured relative to those for the production of B± mesons, times their branching fraction to J/ψK±. The data used for this study correspond to an integrated luminosity of 20.3 fb-1 of pp collisions recorded by the ATLAS detector at the Large Hadron Collider in 201

The coronavirus 2019 (Covid-19) pandemic has affected both the private and public lives of people worldwide. Countries have chosen different strategies to reduce the spread of infection, including school closures and distance learning. This study aimed to describe school nurses’ perceptions about the wellbeing of students during the Covid-19 pandemic in Sweden. Interviews in five focus groups and

Introduction: Rates of delivery by cesarean section have gradually risen in many parts of the world, and it is regarded as a safe surgical procedure with expanded indications. We assessed maternal complications within 6 weeks postpartum after planned cesarean section and after planned vaginal delivery among patients without medical indication for cesarean section. Material and methods: This was a

Persistence of dissolved organic matter (DOM) in aquatic environments may in part be explained by high diversity and low concentrations of carbon substrates. However, changes in dissolved substrate quality can modify aquatic bacterial community composition and rate of carbon uptake. The aim of this study was to test if the presence of multiple simple substrates affects the turnover of organic carb

Leptons with essentially the same properties apart from their mass are grouped into three families (or flavours). The number of leptons of each flavour is conserved in interactions, but this is not imposed by fundamental principles. Since the formulation of the standard model of particle physics, the observation of flavour oscillations among neutrinos has shown that lepton flavour is not conserved

Eye movement modelling examples (EMME) are instructional videos that display a teacher’s eye movements as “gaze cursor” (e.g. a moving dot) superimposed on the learning task. This study investigated if previous findings on the beneficial effects of EMME would extend to online lecture videos and compared the effects of displaying the teacher’s gaze cursor with displaying the more traditional mouse

The pathway to forming the iron-rich planet Mercury remains mysterious. Its core makes up 70% of the planetary mass, which implies a significant enrichment of iron relative to silicates, while its mantle is strongly depleted in oxidised iron. The high core mass fraction is traditionally ascribed to evaporative loss of silicates, for example following a giant impact, but the high abundance of moder

Observations and models of giant planets indicate that such objects are enriched in heavy elements compared to solar abundances. The prevailing view is that giant planets accreted multiple Earth masses of heavy elements after the end of core formation. Such late solid enrichment is commonly explained by the accretion of planetesimals. Planetesimals are expected to form at the edges of planetary ga

Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal and gastric (EG) adenocarcinoma. The aim of this st

Control systems can show robustness to many events, like disturbances and model inaccuracies. It is natural to speculate that they are also robust to sporadic deadline misses when implemented as digital tasks on an embedded platform. This paper proposes a comprehensive stability analysis for control systems subject to deadline misses, leveraging a new formulation to describe the patterns experienc

Weakly-hard models have been used to analyse real-time systems subject to patterns of deadline hits and misses. However, the tools that are available in the literature have a set of shortcomings. The analysis they offer is limited to a single weaklyhard constraint and to patterns that specify the number of misses, rather than the number of hits. Furthermore, the scalability of the tools is limited

The policy used to implement a control algorithm in a real-time system can significantly affect the quality of control. In this paper, we present a method to adapt the controller implementation, with the objective to improve the system’s performance under real-time faults. Our method compensates for missing state updates by adapting the controller parameters according to the number of consecutivel

Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloid precursor protein (APP) can affect synapses remains unclear. Interestingly, early hyperexcitability has been described in human AD and mouse models of AD

Background: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were i