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Kataegis is a hypermutation phenomenon characterized by localized clusters of single base pair substitution (SBS) reported in multiple cancer types. Despite a high frequency in breast cancer, large-scale analyses of kataegis patterns and associations with clinicopathological and molecular variables in established breast cancer subgroups are lacking. Therefore, WGS profiled primary breast cancers (
The location of the Congo-São Francisco (CSF) craton, one of the largest cratons in Proterozoic paleogeography, has been poorly constrained for the supercontinent Nuna interval (ca. 1800–1300 Ma). Initial models of Nuna suggested that the CSF craton was part of the Atlantica continent, together with Amazonia, West Africa, and perhaps Río de la Plata, as a separate continental block from other Nuna
Backround: We wanted to characterize conditional survival in prostate cancer (PC) in Sweden around and after 2005 when the vast increase in incidence due to the opportunistic testing for prostate specific antigen (PSA) culminated. We hypothesize that analyzing survival data during that time period may help interpret survival trends. We focus on stage-specific analysis using conditional survival in
Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and
The joint expression of particular colors, morphologies, and behaviors is a common feature of adaptation, but the genetic basis for such “phenotypic syndromes” remains poorly understood. Here, we identified a complex genetic architecture associated with a sexually selected syndrome in common wall lizards, by capitalizing on the adaptive introgression of coloration and morphology into a distantly r
People with intellectual disabilities commonly experience violent, abusive, and restrictive contexts, particularly those who are at risk of behaviours that challenge, behaviours that often are a sign of trauma, fear, pain, and loss of power. For example, the use of physical restraint and psychotropic medication to manage behaviours labelled as challenging is prevalent in services for people with i
We present a study of the evolution of cosmic filaments across redshift with an emphasis on some important properties: filament lengths, growth rates, and radial profiles of galaxy densities. Following an observation-driven approach, we built cosmic filament catalogues at z = 0, 1, 2, 3, and 4 from the galaxy distributions of the large hydro-dynamical run of the MilleniumTNG project. We employed t
Introduction: The aims were to investigate 1) the frequency of nonsurgical retreatment, root-end surgery, extraction, and further restorative treatment during a follow-up of 10–11 years after root filling and compare the frequencies according to tooth group and type of coronal restoration and 2) the timing of nonsurgical retreatment, root-end surgery, and extraction. Methods: Data were collected f
Coal combustion for energy results in the emission of air pollutants such as NOx and SOx, which negatively affect human health and the environment. Reducing toxic gas emissions and ash production is needed to achieve cleaner coal. This study aimed to develop an extraction method for desulfurizing coal with non-toxic solvents before combustion. Mixtures of sub/supercritical carbon dioxide and ethyl
Theory and practice present opposing views on whether or not companies should strive for multi-tier information sharing (MTIS) in supply chains. The purpose of this study was to identify and explore factors that influence MTIS. We performed a longitudinal Delphi study with 29 supply chain experts, including in-depth interviews and quantitative as well as qualitative analyses. Twelve contextual fac
Background: People with aphasia (PWA) after ischemic stroke often have difficulties in communication and social participation. To individualise rehabilitation and optimise recovery, there is a need for knowledge regarding prevalence of aphasia, and language functions in relation to long-term recovery and health-related quality of life (HRQoL). In this study, we examined these issues in a Swedish s
The complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the breast cancer ecosystem, focusing on the roles of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). We discuss evidence s
Soil factors responsible for the inability of Visearía vulgaris to colonize or survive on calcareous soils in Scandinavia were studied using experiments with plant establishment from seeds and re-establishment of mature plants, in soils of naturally differing or artificially varied chemical properties. Limestone soil proved less suitable for re-establishment of mature plants, and establishment fro
Since the dawn of the Space Age, small cohorts of humanity have broadcast signals towards other stars, fabricated “space-time capsules” to “speak for Earth” aboard interstellar probes, deposited collections of “space oddities” on other astronomical bodies, and permanently incised the memory of our species across the deep-time legacy of the Sol System. Many of these purposeful “messages” are the co
