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We have previously reported suggestive linkage to chromosome 5p13-q13 in type 1 diabetic families. ISL1, a transcription factor involved in pancreas development, maps to this region. Sequencing of the ISL1 gene in patients and control subjects identified seven single nucleotide polymorphisms (SNPs) and one microsatellite in noncoding regions. Four haplotypes formed by six of these SNPs and one mic

Pharmacological experiments were carried out on isolated basilar arteries (BA) from the brain vasculature of guinea-pig and rat in order to characterize post-junctional serotonergic receptors mediating contraction by the use of selective agonists and antagonists. The sensitivity to 5-HT was higher, but the intrinsic activity lower, in guinea-pig compared to rat vessels. The contractile potency of

The measurement of ATP as an estimate of microbial biomass C in humus was studied. Three different acid extractants, H2SO4, TCA and H3PO4 were compared, as well as two different buffers, Tris and arsenate. No difference in extraction efficiency was found when the light output was converted to ATP content using internal ATP standards, but the different extraction agents and buffers influenced the l

Background: Mucins are large complex glycoproteins that protect intestinal mucosal surfaces by limiting access of environmental matter to their epithelial cells. Several mucin genes have been described, including MUC3 that is a membrane associated mucin of the small intestine. Increased MUC3 mRNA transcription is induced by incubation of intestinal epithelial cells with a Lactobacillus strain know

Gamma rays in the N=Z + 1 nucleus Y-79 were identified using the reaction Si-28(Fe-54, p2n)Y-79 at a 200 MeV beam energy and an experimental setup consisting of an array of Ge detectors and the Recoil Mass Spectrometer at Oak Ridge National Laboratory. With the help of additional gamma-gamma coincidence data obtained with Gammasphere, these gamma rays were found to form a strongly coupled rotation

Experimental data on p-n multiplets appearing in the nuclei near double-magic Sn-100 accesible in heavy-ion fusion-evaporation experiments have been analyzed. Proton-rich nuclei in this region have been investigated using the NORDBALL array. A Ni-58 beams at energies of 270 Mev on Fe-54 and 261 MeV on Cr-50 targets were used. Reaction channel separation was achieved with a 4 pi charged particle mu

AIMS: To investigate the disease causing event in patients with familial hypercholesterolaemia, carrying two mutations each, E256K in exon 6 and I402T in exon 9, of the gene encoding the low density lipoprotein (LDL) receptor. It was not known whether the mutations were positioned in cis or trans, or if they were each pathogenic separately or only when present together. METHODS: Polymerase chain r

Popular Abstract in Swedish Denna avhandling i tysk språkvetenskap behandlar en särskild typ av meningar i dagens tyska: påståendesatser med det finita verbet i början. Denna typ har hittills knappast uppmärksammats av forskningen; en av anledningarna till detta är att den oftast förekommer i talat språk. Den vanliga ordföljdsregeln i tyskan är att verbet står på andra plats i huvudsatsen, på sisThe aim of this thesis is to describe and explain independent declarative clauses in German which have the finite verb in absolute clause-initial position. They are called verb-first declarative clauses. It is shown that this type of clause can be found in a variety of Germanic languages. There is evidence suggesting that this is a very old type with roots in ancient Indo-European. It has thus ex

Abstract is not available

Plant biologists have struggled for decades to identify a crucial kinase that orchestrates the transition of the photosynthetic machinery from state 1 to state 2, an energy conserving-process designed to maximize the light conditions. In his Perspective, Allen reveals the identity this kinase and the mechanism by which it controls transitions

Background: CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism. In the present study, we analyzed SIVsm isolates for CD4-independent use of CCR5, mode of CCR5-use and macrophage tropism. The isolates have been collected sequentially from 13 experimentally infected cynomolgus macaques and

Eighteen healthy sedentary males took part in supervised bicycle training for 50 minutes three to five times a week. Twelve subjects (group A) trained for 6 weeks at heavy intensity, and six subjects (group B) trained for 12 weeks at moderate intensity. Maximal oxygen uptake increased by about 20% (P less than 0.01). Body weight and composition as well as diet remained unchanged. After 6 weeks pla

Changes in the electron structure of the surface layer of Nd1.85Ce0.15CuO4 (NCCO) epitaxial films, which were caused by variation of the oxygen content and modification of the crystal structure of samples as a result of Ar+ ion etching and annealing, have been studied by means of photoelectron spectromicroscopy. A method is proposed for the cleaning the surface of oxygen-containing superconductors

Tau-pair production in the process e(+)e(-) --> e(+)e(-) tau(+)tau(-) was studied using data collected by the DELPHI experiment at LEP2 during the years 1997 - 2000. The corresponding integrated luminosity is 650 pb(-1). The values of the cross-section obtained are found to be in agreement with QED predictions. Limits on the anomalous magnetic and electric dipole moments of the tau lepton are dedu