Popular Abstract in Swedish Titeln på den här avhandlingen är ”Nukleinsyror som läkemedel och mål för läkemedel, med fokus på anticanceraktiva platinaföreningar och små interferande RNA”. Nukleinsyror är mer kända som sina förkortningar DNA och RNA. Anticanceraktiva platinaföreningar är en typ av läkemedel mot cancer. Små interfererande RNA är en slags reglermekanism för hur mycket av ett visst prTo ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. The main focus of this thesis has been to evaluate whether siRNA efficiency can be modified by two clinically used anticancer active

The present chapter inquires into to the definition of trafficking in the 2000 Trafficking Protocol. The concept of trafficking seems to offer a self-evident point of departure to broach inequality and migration in the international domain. It emphasises the inequality between trafficker and the trafficked person, and States task themselves to side with the latter - and weaker - party in that rela

Fission track analysis (FTA) was developed to be applied to ultra-low levels of 239Pu in bioassay samples. An analytical protocol was established for the FTA processing. The detection limit was determined to 1.5 µBq and the calibration constant was 24 fission fragments per µBq 239Pu. Naturally occuring nuclides of thorium and uranium, present in biological and environmental samples, did not interf

Evaluating SAR for multi-antennas is difficult and impractical due to the arbitrary power allocation and phase of the electric fields from different antennas causing the total field to change randomly. In this context, a simplified approach was recently proposed for assessing SAR when more than one antenna is transmitting simultaneously. The metric of time averaged simultaneous peak SAR (TASPS) wa

To study and simulate cognitive development, it is useful to find a natural domain where many cognitive functions are needed and, but where the complexity of the environment and task is reasonable. We suggest that childrens games constitute a suitable domain. The ability to play is a very fundamental part of children's daily life and it is crucial for the future development of our behaviors in Bek

The software process simulation research field has been growing in recent years. Much effort has been used for developing detailed software process simulation models. However, few studies are available characterizing the effect process simulation models could have when introduced to an organization. Furthermore, most published work in this area has been focused on the effect that the models have f

Popular Abstract in Swedish En amfifil molekyl innebär en molekyl som består av två delar, en som är hydrofil (“vattenälskande”) och en som är hydrofob (“vattenhatande”). Ofta består den amfifila molekylen av en ”vattenälskande” huvudgrupp och en ”vattenhatande” svans och kallas för surfaktant. Detta beteende ger amfifila molekyler speciella egenskaper. En av de viktigaste egenskaperna är att de kIn this thesis temperature induced vesicle formation in both a block copolymer system and nonionic surfactant system have been investigated. The block copolymer is a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-PPO-PEO, with the average molecular composition of EO5PO68EO5 and the commercial trade name Pluronic L121 (papers I, II). In the L121 system the for

Instructions for the treatment of the insane Duke Magnus of Östergötland (son of Gustav Vasa). Latin text and translation into Swedish

Abstract is not available.

Two-phase flows are commonly found incomponents in energy systems such as evaporators and boilers. Theperformance of these components depends among others on thecontroller. Transient models describing the evaporation process areimportant tools for determining control parameters, and fast loworder models are needed for this purpose. This article describes ageneral moving boundary (MB) model for mod

Female moths emit sex pheromones to lure a mate. In this thesis I examined the transcriptomes of female moth pheromone glands in order to identify genes encoding proteins involved in pheromone production. Two cDNA-libraries were constructed from Agrotis segetum (Noctuidae) pheromone glands and the remaining body tissue, respectively. The libraries were sampled and sequenced. A total of 707 unigene