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Hydrodynamic Forces on Macromolecules Protruding from Lipid Bilayers Due to External Liquid Flows.

It has previously been observed that an externally applied hydrodynamic shear flow above a fluid lipid bilayer can change the local concentration of macromolecules that are associated with the lipid bilayer. The external liquid flow results in a hydrodynamic force on molecules protruding from the lipid bilayer, causing them to move in the direction of the flow. However, there has been no quantitat

Minimalist C/case

This article discusses A-licensing and case from a minimalist perspective, pursuing the idea that argument NPs cyclically enter a number of A-relations, rather than just a single one, resulting in event-licensing, case-licensing and phi-licensing. While argument case commonly reflects Voice/v-relations, canonical A-movement is driven by higher elements, either in the C-T system or in a superordina

Challenging claims in the study of migratory birds and climate change.

Recent shifts in phenology in response to climate change are well established but often poorly understood. Many animals integrate climate change across a spatially and temporally dispersed annual life cycle, and effects are modulated by ecological interactions, evolutionary change and endogenous control mechanisms. Here we assess and discuss key statements emerging from the rapidly developing stud

Discrimination of ST deviation caused by acute coronary occlusion from normal variants and other abnormal conditions, using computed electrocardiographic imaging based on 12-lead ECG.

Many graphical methods for displaying ST-segment deviation in the ECG have been tried for enhancing decision-making in patients with suspected acute coronary syndromes. Computed electrocardiographic imaging (CEI), based on a mathematical inverse solution, has been recently applied to transform ST-J point measurements made in conventional 12-lead ECG into a display of epicardial potentials in bull'

A Quantitative Balian-Low Theorem

We study functions generating Gabor Riesz bases on the integer lattice. The classical Balian-Low theorem (BLT) restricts the simultaneous time and frequency localization of such functions. We obtain a quantitative estimate on their Zak transform that extends both this result and the more general (p,q) Balian-Low theorem. Moreover, we establish a family of quantitative amalgam-type Balian-Low theor

Can there only be one? Towards a post-paradigmatic service marketing approach

Purpose – The purpose of this paper is to unlock positions regarding the goods/services dichotomy in service marketing and to offer an argument that treats goods and services on an ontologically equal basis. Design/methodology/approach – A close reading of influential texts that argue in favor of a service-dominant logic (SDL) and new paradigms in service marketing. Findings – Both the SDL pro

A Holocene peat record in the central South Atlantic: an archive of precipitation changes

Peat deposits from the littoral part of the wetland 2nd Pond on Nightingale Island in the central South Atlantic have been analysed to investigate the Holocene climate development on the island and to test a hypothesis about regionally persistent humidity variations. A variety of proxies were analysed - total carbon and nitrogen, biogenic silica, diatoms, amount of organic matter, macrofossils and

Semantic profiles of antonymic adjectives in discourse

This study has two goals: Firstly, to give an account of the semantic organization of individually used antonymic adjectives in discourse, and secondly, based on these finding, and previous work on antonymic meanings, contribute to a comprehensive theoretical account of their representation within the framework of Cognitive Linguistics. The hypothesis is that the members of the pairs are used in t

APP/APLP2 expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.

Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 (Gpc-1) is generated in endosomes by an endogenously or ascorbate induced SNO-catalyzed reaction. Processing of the amyloid precursor protein (APP) and APP-like protein 2 (APLP2) by β- and γ-secretases into amyloid beta (Aβ) and Aβ-like peptides also takes place in these compartments. Moreover, anMan-co

J/psi Polarization in pp Collisions at root s=7 TeV

The ALICE Collaboration has studied J/psi production in pp collisions at root s = 7 TeV at the LHC through its muon pair decay. The polar and azimuthal angle distributions of the decay muons were measured, and results on the J/psi polarization parameters lambda(theta) and lambda(phi) were obtained. The study was performed in the kinematic region 2: 5 < y < 4, 2 < p(t) < 8 GeV/c, in the helicity an

Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.

Based on a pharmacophore model of the benzodiazepine-binding site of GABA(A) receptors, a series of 2-aryl-2,6-dihydro[1,2,4]triazolo[4,3-c]quinazoline-3,5-diones (structure type I) were designed, synthesized, and identified as high-affinity ligands of the binding site. For several compounds, K(i) values of around 0.20nM were determined. They show a structural resemblance with the previously descr

Search for supersymmetry in events with large missing transverse momentum, jets, and at least one tau lepton in 20 fb(-1) of root s=8 TeV proton-proton collision data with the ATLAS detector

A search for supersymmetry (SUSY) in events with large missing transverse momentum, jets, at least one hadronically decaying tau lepton and zero or one additional light leptons (electron/muon), has been performed using 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectatio

Humanistic and normativistic metaphysics, epistemology, and conative orientation: Two fundamental systems of meaning

Polarity Theory suggests that worldview controversies spanning areas such as morality, politics, epistemology, and metaphysics are ultimately rooted in the clash between humanism, which portrays human nature as intrinsically good and valuable, and normativism, which portrays human goodness and value as contingent upon conformity and achievement. Previous research has shown that humanism and normat

Combined effects of global change pressures on animal-mediated pollination

Pollination is an essential process in the sexual reproduction of seed plants and a key ecosystem service to human welfare. Animal pollinators decline as a consequence of five major global change pressures: climate change, landscape alteration, agricultural intensification, non-native species, and spread of pathogens. These pressures, which differ in their biotic or abiotic nature and their spatio

Nonmedical Prescription Drug Use (NMPDU) in the Swedish General Population-Correlates of Analgesic and Sedative Use.

Background: Nonmedical prescription drug use (NMPDU) is a growing problem in many countries. Objectives: The aim of the present study was to report correlates of and compare different subtypes of NMPDU in the Swedish general population. Methods: Data were drawn from a Swedish national household survey conducted in 2008-2009. A stratified sample of 58,000 individuals aged 15 to 64 was randomly sele

Arsenic trioxide is a novel agent for combination therapy to prolong heart allograft survival in allo-primed T cells transferred mice

Alloreactive memory T cells are major barriers to transplantation acceptance due to their capacity to accelerate rejection. Here, we investigated the effects of combined treatment with arsenic trioxide (As(2)O(3)) and blocking monoclonal antibodies (mAb) against CD154 and LFA-1 (anti-CD154/LFA-1) on graft survival as well as changes in pathology and immunological responses in mice with adoptively

Deriving seasonal dynamics in ecosystem properties of semi-arid savanna grasslands from in situ-based hyperspectral reflectance

This paper investigates how hyperspectral reflectance (between 350 and 1800 nm) can be used to infer ecosystem properties for a semi-arid savanna grassland in West Africa using a unique in situ-based multi-angular data set of hemispherical conical reflectance factor (HCRF) measurements. Relationships between seasonal dynamics in hyperspectral HCRF and ecosystem properties (biomass, gross primary p