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Multiple myeloma (MM) is the second most common hematological malignancy, characterized by a clonal expansion of malignant plasma cells in bone marrow. Monoclonal gammopathy of undetermined significance (MGUS) is the premalignant condition of MM. The tumor microenvironment is thought to influence the progression from premalignant conditions. Myeloid-derived suppressor cells (MDSCs) are a heterogen
BACKGROUND: The involvement of the complement system in anti-glomerular basement membrane (GBM) disease is well known but incompletely characterized. The ability of autoantibodies to trigger the classical pathway is evident, while the lectin and alternative pathways also seem to be of importance. We studied complement activation in patients treated with imlifidase, which leads to rapid IgG depleti
Wind energy is an increasingly viable solution for sustainable power generation, particularly in developing regions with high wind potential. This paper presents a comprehensive analysis of the wind power and energy output estimation for the Sela Dingay wind farm, a candidate site in Ethiopia. The study utilizes measured wind speed data at 50 meters and interpolates it to different hub heights (91
Critical Management Studies (CMS) has largely relied on one-dimensional critique which focus on the negation of a dominant social order. This strong focus has made the field increasingly stale and preoccupied with standard objects for critique. This paper suggests that if CMS is to move beyond these problems, it needs to develop three-dimensional thinking, including understanding, questioning, and
PURPOSE: To examine sex differences in health-related quality of life (HRQoL) among patients surgically treated for renal cell carcinoma (RCC) in Sweden, utilizing data from the National Swedish Kidney Cancer Register (NSKCR).METHODS: In this study of 4658 surgically treated RCC patients, data on HRQoL, clinical, demographic, and socioeconomic characteristics were retrieved from the NSKCR for pati
We identify managers' meta-level talk about the positive purpose, meaning, and significance of their actions as an overlooked type of leadership behaviour and call it leadership meta-talk. We outline why leadership meta-talk is not necessarily truthful or deceptive, but selective and loosely coupled with leadership practice. We discuss varieties of leadership meta-talk, namely aspirational, sub-te
Accurately predicting the macroscopic behaviour of heterogeneous materials, particularly in thermo-electrically coupled systems, remains a challenging problem in materials science and engineering. Against this background, this study presents a comprehensive framework for the homogenisation of electrical conductors subject to strongly coupled thermo-electrical processes in (quasi-)stationary settin
Explicit finite element schemes are extensively used in industrial applications characterised by elevated strain rates and complex contact interactions. A central challenge in such simulations is the achievement of mesh-independent results while accurately capturing damage localisation and evolution. Gradient-enhanced damage models provide a robust regularisation framework. However, using a microm
Introduction: Major depressive disorder (MDD) is associated with cognitive impairment, including verbal memory. Limited knowledge exists following memory performance in first episode (FE) MDD. This study investigated verbal memory, depressive symptoms, and relapse in FE MDD over five years, from the trait, state, and scar perspectives. These perspectives suggests that deficits in memory either pre
Abstract Introduction: Epidemiologic studies of hidradenitis suppurativa (HS) from Sweden are limited. The aim of this study was to investigate the prevalence of HS in Lund and Gothenburg, Sweden. Methods: This study was a part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative. The study was multicentered and included apparently healthy adults accompanying a patient to the Department
The finite element (FE) method is one of the approaches available for solving different types of partial differential equations in the various fields of physics, such as solid mechanics, heat transfer, and electromagnetics. Visualization and manipulation of results play a crucial role in the interpretation and analysis of simulation results, especially when complex and advanced problems are consid
Data-driven mechanics offers great potential in engineering applications, where the efficient simulation of complex and, in particular, path-dependent material behavior is often challenging. Within this approach, conventional material models are replaced by data sets containing snapshots of stress, strain and the history of both assumed to be sufficiently accurate representations of the underlying
The solution of coupled multi-field problems by means of commercially available finite element codes such as Abaqus constitutes an important part in the study of industrial processes. Against this background, a comprehensive implementation framework for a gradient-enhanced continuum damage formulation in a thermo-mechanically coupled finite deformation setting is proposed in this contribution. To
Introduction: Globally, many adolescents suffer from mental health problems and related stigma. Assessing mental health stigma among youth is crucial to addressing this problem. The aim of this study was to examine the psychometric properties of a modified version of the Attitudes About Mental Illness and its Treatment (AAMIT) instrument and to describe attitudes according to the instrument, among
In manufacturing, thermomechanical processes such as static annealing and hot working are commonly used to tailor the microstructure of metals to achieve favourable macroscopic material properties that meet specific application requirements. To improve sequential manufacturing processes and to accurately predict the microstructural changes of the material along the process chain, physically motiva
Understanding damage mechanisms and quantifying damage is important in order to optimise structures and to increase their reliability. To achieve this goal, experimental- and simulation-based techniques are to be combined. Different methods exist for the analysis of damage phenomena such as fracture mechanics, phase field models, cohesive zone formulations and continuum damage modelling. Assuming
Data-driven methods provide great potential for future applications in engineering, for example in terms of more efficient simulations. Conventional material models and the associated constitutive equations are substituted by a minimization of a distance between so-called material and mechanical states, which, however, leads to non-unique solutions. The aim of this paper is to analyze the influenc
Building on the role of trust in finance and screening theory, our research explores the correlation between founders occupying leadership positions such as CEO, CTO, or CFO and the funds raised through Initial Coin Offerings (ICOs). We analyse data from 2,047 ICOs between 2017 and 2021 and reveal that founders occupying positions of authority within their organisations are perceived by investors
