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BACKGROUND: Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown.METHODS: We studied 13,893 first-born a

OBJECTIVE: To study the extent to which BMI after pregnancy adds to the elevated risk of postpregnancy type 2 diabetes in women with a history of hypertensive disorders of pregnancy (HDP) (preeclampsia or gestational hypertension).RESEARCH DESIGN AND METHODS: We used data from the Nurses' Health Study II, a prospective cohort study. In women aged 45-54 years without prior gestational diabetes mell

Accumulation of damaged or misfolded proteins resulted from oxidative protein modification induces endoplasmic reticulum (ER) stress by activating the pathways of unfolded protein response. In pathologic hemolytic conditions, extracellular free hemoglobin is submitted to rapid oxidation causing heme release. Resident cells of atherosclerotic lesions, after intraplaque hemorrhage, are exposed to he

During the last glacial period Northern Hemisphere climate was characterized by extreme and abrupt climate changes, so-called Dansgaard-Oeschger (DO) events. Most clearly observed as temperature changes in Greenland ice-core records, their climatic imprint was geographically widespread. However, the temporal relation between DO events in Greenland and other regions is uncertain due to the chronolo

Production of π0 and η mesons has been measured at midrapidity in Cu+Au collisions at sNN=200GeV. Measurements were performed in π0(η)→γγ decay channel in the 1(2)-20GeV/c transverse momentum range. A strong suppression is observed for π0 and η meson production at high transverse momentum in central Cu+Au collisions relative to the p+p results scaled by the number of nucleon-nucleon collisions. In

Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. We studied matched knee synovial fluid

Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental impairment and attained regional brain volumes is unknown. Methods: We studied 23 preterm children with FGR (PT-FGR), 24 matched preterm children AGA (PT-AGA), and 27 matched term AGA children (T-AGA) by measuring brain volum

Powder materials containing copper ions supported on ZSM-5 (Cu-Zeolite Socony Mobil-5) and SSZ-13 (Cu-Standard Oil synthesised zeolite-13), and predominantly CuO nanoparticles on amorphous SiO2 were synthesised, characterised, wash-coated onto ceramic monoliths and, for the first time, compared as catalysts for direct conversion of methane to methanol (DCMM) at ambient pressure (1 atm) using O2, N

We measured direct photons for pT<5GeV/c in minimum bias and 0%–40% most-central events at midrapidity for Cu+Cu collisions at √sNN=200GeV. The e+e− contribution from quasireal direct virtual photons has been determined as an excess over the known hadronic contributions in the e+e− mass distribution. A clear enhancement of photons over the binary scaled p+p fit is observed for pT<4GeV/c in Cu+Cu d

Human carbonic anhydrase IX (CA IX) is a multi-domain membrane protein that is therefore difficult to express or crystalize. To prepare crystals that are suitable for neutron studies, we are using only the catalytic domain of CA IX with six surface mutations, named surface variant (SV). The crystallization of CA IX SV, and also partly deuterated CA IX SV, was enabled by the use of microseed matrix

Stricter building regulations have resulted in the construction of buildings with a low energy use during the operation phase. It has now become increasingly important to also look at the embodied energy, because it might, over the lifespan of the building, equal the energy used for operating the building. One way to decrease the embodied energy is to reuse building materials and components or to

Aims: Chronic left atrial enlargement (LAE) increases the risk of atrial fibrillation. Electrocardiogram (ECG) criteria might provide a means to diagnose LAE and identify patients at risk; however, current criteria perform poorly. We seek to characterize the potentially differential effects of atrial dilation vs. hypertrophy on the ECG P-wave. Methods and results: We predict effects on the P-wave

This paper presents a procedure to derive a thermal lumped-parameter grey-box model of an electric machine built for traction. The procedure includes experimental data logged under overload conditions for accurate temperature prediction at high currents, and features a relatively simple loss estimation approach. Validation of the model shows a good fit between measured and simulated results. Possi

This article presents a concept of direct cooled windings for electrical machines, pumping air through hollow rectangular copper windings. The thermal constraints pose a serious limitation in the performance of many applications of electrical machines, not least in electrical vehicles. The difference between temporary maximum output and continuous output is often substantial. This difference can b

This paper explores and assesses power loss generation and heat extraction in a stator with directly air-cooled laminated winding. An electrical machine winding made of an electric conducting sheet, which have slotted structure for accommodating a magnetic core, is denoted a laminated winding. A space is introduced between the conducting sheets so that the heating power is removed right where it i

This paper presents and assesses the cooling integration of electrical machines with concentrated windings. A conventional coil in a concentrated winding with forced cooling applied on the exterior coil surfaces is replaced by an alternative solution where the coil is opened up in a laminar structure with the intention of the coolant fluid penetrating the coil and removing the interior heat. This

This paper explores the urban form, demographic and socio-economic dependencies of walking, cycling and e-biking in Beijing based on a survey (N = 1427) of daily travel among residents in eight neighborhoods, enriched with urban form variables. The results show that walking is most frequently used, followed by cycling, which in turn is more frequent than e-biking. Walking and cycling are preferred