Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the S

Objective: This study was undertaken to develop and characterize a multiplex immunoassay for detection of autoantibodies against peptides derived from proteins known to play a role in development of arthritis and that are also expressed in joints. Methods: We selected peptides from the human counterpart of proteins expressed in the joints, based on mouse models that showed these to be targeted by

This work introduces the high-energy surface X-ray diffraction analysis toolkit (HAT), an open-source cross-platform software package written in Python to allow the extraction and processing of high-energy surface X-ray diffraction (HESXRD) data sets. Thousands of large-area detector images are collected in a single HESXRD scan, corresponding to billions of pixels and hence reciprocal space positi

Implementing appropriate policies is crucial for adapting the agricultural sector to climate change. However, adopting incorrect policies can exacerbate unsustainable development. Hence, this study investigated the unintended consequences of agritourism development policies as a climate change adaptation strategy in the villages of Shahrud, Iran. It demonstrated how such policies have inadvertentl

From a cohort of 171 patients comprising 121 aggressive pituitary tumours (APT) and 50 pituitary carcinomas (PC), the clinicopathological or five-tiered classification based on tumour invasion and proliferation evaluated by at least 2 proliferative markers over the cut-offs (Ki-67 ≥3% or ≥10%, p53 positive or expressed in %, mitotic count >2%), could be applied on 43 tumours: 20 PC and 23 APT. At

n this introductory chapter, we outline the literature in which the anthology is positioned and the anthology’s contribution hereto. We account for the questions addressed in the anthology and its structure based on three sections that each analyses transformations of European welfare states and social rights from macro, meso and micro level perspectives, respectively. As described in the chapter

The aim of this work is to investigate the planar LIF/Mie droplet sizing technique from an experimental and theoretical point of view. This technique is a good alternative compared to point measurements (e.g., phase Doppler anemometry) or integral approaches (e.g., laser diffraction). It allows measurement of the Sauter mean diameter over a wide field, providing the spray topology and droplet size

Microbial carbon use efficiency (CUE) and nitrogen use efficiency (NUE) are key parameters determining the fate of C and N in soils. Atmospheric N deposition has been found to heavily impact multiple soil C and N transformations, but we lack understanding of the responses of CUE and NUE to N deposition, and it remains uncertain whether responses may be mediated by topography. Here, a N addition ex

This chapter offers a bottom-up perspective on welfare rights in practice, analysing legal mobilisation by young persons in homelessness in the Danish welfare state. Youth homelessness is selected as case motivated by the fact that the number of persons aged 18 to 29 living in homelessness almost doubled from 2009 to 2019. Drawing on the young persons’ narratives, the chapter stresses that their r

Antagonistic coevolution (i.e., reciprocal adaptation and counter-adaptation) between hosts and pathogens has long been considered an important driver of genetic variation. However, direct evidence for this is still scarce, especially in vertebrates. The wealth of data on genetics of susceptibility to infectious disease in humans provides an important resource for understanding host-pathogen coevo

In October 2019, Zlatan Ibrahimović, the most successful and famous Swedish football player ever, was honoured with a monument by the Swedish Football Association and the city of Malmö. Born in Malmö in 1981, Ibrahimović grew up in a migrant area of the city (Rosengård). Growing up, he played football in local teams, and at the age of 19 he was sold by Malmö FF to Ajax for the highest transfer fee

Sarcomeric hypertrophic cardiomyopathy (HCM) is a prevalent genetic disorder characterised by left ventricular hypertrophy, myocardial disarray, and an increased risk of heart failure and sudden cardiac death. Despite advances in understanding its pathophysiology, treatment options for HCM remain limited. This narrative review aims to provide a comprehensive overview of current clinical practice a

With the trend of transport electrification, the fleet of delivery and transport vehicles with internal combustion engines taking fossil fuel in the terminals of logistics companies should be gradually replaced by electric vehicles (EVs). Expansion planning of the power system in the terminal is needed to meet the increased EV charging need. Different expansion solutions with variable technologies

Halite (NaCl mineral) has exhibited the potential to preserve microorganisms for millions of years on Earth. This mineral was also identified on Mars and in meteorites. In this study, we investigated the potential of halite crystals to protect microbial life-forms on the surface of an airless body (e.g., meteorite), for instance, during a lithopanspermia process (interplanetary travel step) in the

The analysis of the current state of fire statistics and data collection in Europe and other countries is needed to increase awareness of how fire incidents affect buildings and to support pan-European fire prevention and fire mitigation measures. The terminology and data collected regarding fire incidents in buildings in the EU Member States were mapped to obtain meaningful datasets to determine

Objective: Patient-centred learning (PCL) allows medical students to practice a patient-centred approach; however, didactic characteristics of PCL have yet to be fully elucidated. Clinical placements structured as a student clinic (SC) enable authentic student-patient learning relations through enhanced student responsibility and can serve as examples of PCL. We explored the didactic characteristi

Introduced social insects can be highly invasive outside of their native range. Around the world, the introduction and establishment of the eusocial bumblebee Bombus terrestris (L. 1758) (Hymenoptera: Apidae) has negatively impacted native pollinators and ecosystems. Understanding how morphological variation is linked to environmental variation across invasive ranges can indicate how rapidly speci

We use Helianthemum oelandicum subsp. oelandicum as a model for studies of mechanisms shaping the diversity in a rapidly radiating lineage of the H. oelandicum aggregate. Locally, correlations between drainage conditions (using GIS to measure variation in the micro-Topography on the more or less horizontal bedrock) and frequency of alleles of Mendelian genes for pubescence indicated that hairs are