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Levodopa-induced dyskinesia (LID) is a debilitating complication of symptomatic therapy in Parkinson's disease. Although there is compelling evidence that striatal pathophysiology is a major driver of LID, the specific circuit mechanisms governing its expression remain obscure. To address this gap, molecular, cellular, and behavioral strategies were used to interrogate circuits in a mouse model of
This position paper examines the growing dominance of health economics in Swedish healthcare governance and argues that its elevated epistemic authority produces significant risks for the sustainability and ethical integrity of care systems. Drawing on feminist theories of care and critical political economy, the paper interrogates the assumption that care can be adequately represented, valued, or
Background: Upper tract urothelial carcinoma (UTUC) is rare, and contemporary data on real-world healthcare resource utilisation and costs are limited. The objective of this study is to describe long-term healthcare resource utilisation among patients with upper tract urothelial carcinoma (UTUC) and to identify clinical and treatment-related drivers of costs. Methods: We conducted a retrospective,
In this study we compared the latencies and amplitudes of pupillary light responses, recorded by a Tobii Pro Spark eye-tracker and a setup combining PupilEXT, a free open-source software for pupillometry, with an industrial camera. Pupil size was recorded simultaneously with both systems while illumination was provided by the Spark. Results show that neither pupillary response latencies nor amplit
Under rentier capitalism, class struggle extends beyond production, encompassing the entire process of value appropriation, circulation and distribution. Housing is a stark example. In post-war Nordic welfare states, organised labour played key roles in endorsing wide provision of affordable social housing. Today, workers are not only dominated as wage-labourers but also as tenants and debtors, st
We present PyeLink and SyeLink, two complementary open-source Python tools for running eye-tracking experiments and parsing data from SR Research Ltd. EyeLink eye tracking hardware. PyeLink simplifies experiment creation through plug-and-play support for multiple display backends (Pygame, PsychoPy, Pyglet) while enabling two features not available in existing tools: recording data during calibrati
As posited in this themed issue, the notion of platformed communities accounts for a multitude of relations between users, content creators and platforms. This article analyses how synthetic influencers negotiate existing practices of community building in creator cultures. It frontloads how boundaries of communal and commodified online environments are further blurred in platformed cultural produ
We study the relationship between the structural transformation of the economy and theincome distribution, focusing on the case of Sweden from 1870 to 1970, with extra attentionpaid to the 1870–1950 period, for which we produce extensive new data. Average incomeincreased fivefold between 1870 and 1950, and the share employed in agriculture declinedfrom 72 to 23 per cent. To study the evolution of
SUMMARYThe transcriptional regulator NrdR is present in most bacteria and in some archaea, but is lacking in eukaryotes. It controls the expression of operons of the universal and essential ribonucleotide reductase (RNR) enzymes, which provide building blocks of DNA by reducing ribonucleotides to their corresponding deoxyribonucleotides. The NrdR protein consists of an N-terminal zinc-ribbon domai
BACKGROUND: In Sweden, approximately half of all individuals who die receive municipal care prior to death. Access to high-quality palliative care remains unequal, with known disparities between both care settings and diagnostic groups. Individuals receiving municipal home care are at higher risk of acute hospital admissions and in hospital death than those in long-term care facilities. However, t
This study examined the relationship between motion sickness and physiological responses in a driving simulator (N = 20) and a real vehicle (N = 10). Subjective motion sickness severity was assessed using the Misery SCale (MISC) while electroencephalogram (EEG) and electrocardiogram (ECG) were recorded. MISC ratings over time classified participants as tolerant (mild, stable discomfort) or vulnera
Learning accurate and stable time-advancement operators for nonlinear partial differential equations (PDEs) remains challenging, particularly for chaotic, stiff, and long-horizon dynamical systems. While neural operator methods such as the Fourier Neural Operator (FNO) and Koopman-inspired extensions achieve good short-term accuracy, their long-term stability is often limited by unconstrained late
We introduce the Koopman-inspired Fourier Neural Operator (kFNO) for predicting complex flame instabilities governed by nonlinear PDEs. Leveraging Koopman theory to lift dynamics into a high-dimensional latent space, kFNO improves short-term accuracy and long-term statistical fidelity. We validate kFNO on synthesized flame fronts from re-scaled Sivashinsky equations (modeling hybrid Darrieus–Landa
Objective: Knee osteoarthritis (OA) is a chronic joint disease associated with pain and reduced function. The mechanisms underlying OA and how mechanical properties change with the disease are not fully understood, partly due to large variability during mechanical testing of cartilage. We characterized the mechanical properties of human femoral cartilage with varying levels of degeneration using a
