In a search for new inhibitors of the IFN-γ mediated signal transduction in HeLa S3 cells using secreted alkaline phosphatase (SEAP) as reporter gene, a novel compound, designated as S14-95 was isolated from fermentations of the imperfect fungus Penicillium sp. 14-95. The compound inhibits the IFN-γ mediated expression of the reporter gene with IC50 values of 2.5~5μg/ml (5.4~10.8μM). Furthermore t

In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research. This report deals with interactions between chemotherapy, endocrine therapy, other anti-tumour drugs and radiation.

The optimisation of image quality vs. radiation dose is an important task in medical imaging. To obtain maximum validity of the optimisation, it must be based on clinical images. Images at different dose levels can then either be obtained by collecting patient images at the different dose levels sought to investigate-including additional exposures and permission from an ethical committee-or by man

Exemplifying a rather widespread attitude among Pauline scholars, it has recently been argued on the basis of Rom. 12 that Paul differed sharply from the Stoics in his moral teaching. The present article aims to show that such a claim does not hold if and when the sources of Roman Stoicism are taken into consideration. A comparison of Paul’s moral teaching in Rom. 12 and contemporary Stoic ethics

Hur kan det komma sig att en relativt stor andel lärare på en och samma gång är missnöjda med en rad arbetsvillkor och upplever att arbetet är meningsfullt? Varför är, med andra ord, många lärare nöjda med sin yrkesutövning som lärare samtidigt som de är missnöjda som anställda? Frågeställningarna har attackerats från flera håll med utgångspunkt från läraryrkets och skolans utveckling under de sen

The neutron-rich isotope Sb-136 has been produced following the relativistic projectile fission of U-238 in an experiment performed at the Fragment Separator at GSI, Darmstadt. Delayed gamma -ray spectroscopy of the fission products has been performed after isotope separation. A new isomeric state in Sb-136 has been populated, and its lifetime measured as T-1/2 = 565(50) ns. Realistic and empirica

De Geer moraine ridges occur in abundance in the coastal zone of northern Sweden, preferentially in areas with proglacial water depths in excess of 150 m at deglaciation. From detailed sedimentological and structural investigations in machine-dug trenches across De Geer ridges it is concluded that the moraines formed due to subglacial sediment advection to the ice margin during temporary halts in

Catheter-related deep venous thrombosis is a complication that can occur in patients receiving chemotherapy. Three such cases are described and a review of the literature is made, focusing on recent results regarding possible thrombogenic mechanisms and the high prevalence of non-symptomatic thrombosis as well as the high morbidity and mortality associated with upper extremity deep venous thrombos

A survey of transfusion-dependent thalassaemia was conducted to study epidemiology, treatment and follow-up routines as a basis for future discussions. Questionnaires were sent to 97 clinics in Sweden. Responses were submitted by 86 of the clinics, 21 of which cared for 32 patients (18 children, 14 adults; i.e.only one or a few patients per hospital). Ten of those 32 (33 procent) patients were bor

Chemical control of desert locust (DL) is carried out over large areas of land, covering a range of different landscapes and ecosystems. There are no real restrictions for spraying in or close to environmentally sensitive areas and awareness of sensitivity is not always obvious to the people involved in control. However, concern about environmental issues in connection with DL control is growing a

Popular Abstract in Swedish Cystatiner är endogena proteasinhibitorer som reglerar den proteolytiska aktiviteten hos papainlika cysteinproteaser, så som humant cathepsin B, H, K, L och S. Cystatin C, som finns i de flesta humana vävnader och vävnadsvätskor, är den starkaste hämmaren av lysosomala cysteinproteaser. Förändring i balansen mellan cysteinproteaser och cystatiner har vid flera olika canCystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. Alterations in the balance between the cy

The heat requirement of a building can turn out to be greater than was calculated at the design stage. The reason for this may be that heat transport though the building envelope is greater than expected. This in turn can be due to the structure not fulfilling the design requirements in respect of windtightness and airtightness. In addition, there may be defects in the quality of the workmanship o

Anaerobic digestion is a suitable method for the treatment of wastewater and organic wastes, yielding biogas as a useful by-product. A common way of preventing instability problems and avoiding acidification in anaerobic digesters is to keep the organic load to the digester far below its maximum capacity. An improved way of operating digesters would be to use monitoring and control systems for inc

Swallowing problems are common, with a prevalence of 5-30% in different populations. Clinical work-up must start with a careful evaluation of the symptomatology, which should then lead to appropriate investigations. A crucial point in the evaluation of these patients is the comparison between the patient's symptoms and the findings during the examination. Symptoms and findings often do not match,