Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in monocytes and macrophages in a time- and temperature-dependent manner. In this study, we investigated which endocytosis pathways are responsible for the i

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi

A public housing company has applied a new renovation strategy, comprising no standards raising and thus rent-raising measures, in 20% of its apartments. Prior to renovation, the tenants were given the opportunity to choose renovation options involving different standards and costs after renovation. The purpose of the study is to follow up and give feedback on the renovation strategy. The aim was

Background: Patients with dementia have an increased risk of developing epilepsy, es-pecially in patients with vascular dementia and Alzheimer’s disease. In selecting the optimal an-ti-epileptic drug (AED), the possible side effects such as drowsiness and worsening of cognitive function should be taken into consideration, together with co-morbidities and type of epilepsy. Objective: The current sy

ZnO-water nanofluid in an inner pipe was experimentally investigated to improve the thermal efficiency of double-pipe heat exchangers. In this work, a 57.6% increase in the Nusselt number was obtained at Re = 14,340 when the ZnO-water nanofluid flowed through a helically corrugated tube. It was found that helical corrugation played a more important role in heat transfer enhancement than thermophys

Background: Severe hereditary alpha-1-antitrypsin deficiency (AATD) is a known risk factor for the early development of pulmonary emphysema and COPD, especially in smo-kers. By the Swedish national screening programme carried out from 1972 to 1974, a cohort of individuals with severe (PiZZ) AATD was identified and has been followed up regularly. The aim of this study was to investigate health stat

In this paper we study structure from motion problems for 1D radial cameras. Under this model the projection of a 3D point is a line in the image plane going through the principal point, which makes the model invariant to radial distortion and changes in focal length. It can therefore effectively be applied to uncalibrated image collections without the need for explicit estimation of camera intrin

The ability for groups to engage in collective action depends on a variety of factors, ranging from social organization to resources to political opportunities amongst others. Yet, on a much more basic level, collective action is dependent on the ability of individuals to come together to interact and coordinate action, or in other words, to create a collective. Individuals must have spaces in whi

En större mängd kvartsavslag och brända ben, upptäckta vid rekognosering (Norrbottens Museum) av hyggesberedda ytor norr om byn Sammakko, c. 40 km SO Gällivare, har tolkats att indikera ett kortvarigt använt boplatsområde. Platsen, liggande c. 100 meter norr Linaälven och i kanten av en nästan igenväxt göl, genomgick arkeologisk förundersökning sommaren 2019. Insamlat material av brända ben och trA large number of quartz fragments from knapping andburnt bone, discovered during reconnaissance (NorrbottensMuseum) of forest-cleared areas north of the villageSammakko, c. 40 km SE of Gällivare, have been interpretedto indicate a short-term used dwelling site. Th esite, located c. 100 meters north of the Linaälven Riverand at the edge of an almost overgrown pond, underwentarchaeological prelimin

Proper emergency evacuation planning is a key to ensuring the safety and efficiency of resources allocation in disaster events. An efficient evacuation plan can save human lives and avoid other effects of disasters. To develop effective evacuation plans, this study proposed a multi-objective optimization model that assigns individuals to emergency shelters through safe evacuation routes during the

Climate denial takes many forms, ranging from outright denial of facts (literal denial), over distortion of facts (interpretive denial, e.g., denial of personal and global outcome severity), to the acknowledgement of facts but denial of their implications (implicatory denial, e.g., avoidance, denial of guilt, rationalization of own involvement). This study aimed at furthering the understanding of

In this article we examine the future of human rights by looking at how ‘authoritarianism’, in its multifaceted forms and manifestations, intersects with existing discourses on climate change, environmental protection, populism and ‘gender deviance’. By adopting an intersectional lens, we interrogate the emergence of the right to a healthy environment and reflect on whether it will help against th

OBJECTIVES: To investigate if the risk of prostate cancer (PC) differs based on the order of primary PC diagnosed in first-degree relatives (FDRs) given possibly different risk factors for PC as first primary cancer (PCa-1) and second primary cancer (PCa-2).SUBJECTS AND METHODS: In this Swedish nationwide cohort, PC diagnosis was followed for among 149,985 men with one FDR affected by PCa-1, 10,97

With the help of modern technologies and advances in communication systems, the functionality of Industrial control systems (ICS) has been enhanced leading toward to have more efficient and smarter ICS. However, this makes these systems more and more connected and part of a networked system. This can provide an entry point for attackers to infiltrate the system and cause damage with potentially ca