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Multicriteria evaluation of discharge simulation in Dynamic Global Vegetation Models

In this study, we assessed the performance of discharge simulations by coupling the runoff from seven Dynamic Global Vegetation Models (DGVMs; LPJ, ORCHIDEE, Sheffield-DGVM, TRIFFID, LPJ-GUESS, CLM4CN, and OCN) to one river routing model for 16 large river basins. The results show that the seasonal cycle of river discharge is generally modeled well in the low and middle latitudes but not in the hi

Gene expression profiling of placentae from women with early- and late-onset pre-eclampsia: down-regulation of the angiogenesis-related genes ACVRL1 and EGFL7 in early-onset disease

The underlying mechanisms behind the obstetric condition pre-eclampsia (PE) are still unclear. Manifestation of PE is heterogeneous and it has therefore been proposed to be a syndrome with different causes rather than one disease with a specific aetiology. Recently, we showed differences in circulating angiogenic factors between two subgroupsearly- and late-onset PE. To further elucidate the diffe

Nonconvergence to saddle boundary points under perturbed reinforcement learning

For several reinforcement learning models in strategic-form games, convergence to action profiles that are not Nash equilibria may occur with positive probability under certain conditions on the payoff function. In this paper, we explore how an alternative reinforcement learning model, where the strategy of each agent is perturbed by a strategy-dependent perturbation (or mutations) function, may e

Interdisciplinary archaeological prospection, excavation and 3D documentation exemplified through the investigation of a burial at the Iron Age settlement site of Uppåkra in Sweden

This paper presents the archaeological prospection, excavation and digital three-dimensional documentation of a previously unknown neolithic grave, presumably late neolithic, at the outstanding Iron Age site of Uppåkra in southern Sweden, and exemplifies a multidisciplinary approach to modern archaeological fieldwork. In the framework of a large-scale archaeological prospection pilot study conduct

Leading edge vortex in a slow-flying passerine.

Most hovering animals, such as insects and hummingbirds, enhance lift by producing leading edge vortices (LEVs) and by using both the downstroke and upstroke for lift production. By contrast, most hovering passerine birds primarily use the downstroke to generate lift. To compensate for the nearly inactive upstroke, weight support during the downstroke needs to be relatively higher in passerines wh

Unexpected Decoupling of Stretching and Bending Modes in Protein Gels

We show that gels formed by arrested spinodal decomposition of protein solutions exhibit elastic properties in two distinct frequency domains, both elastic moduli exhibiting a remarkably strong dependence on volume fraction. Considering the large difference between the protein size and the characteristic length of the network we model the gels as porous media and show that the high and low frequen

Life cycle assessment of a household solid waste source separation programme: a Swedish case study.

The environmental impact of an extended property close source-separation system for solid household waste (i.e. a systems for collection of recyclables from domestic properties) is investigated in a residential area in southern Sweden. Since 2001, households have been able to source-separate waste into six fractions of dry recyclables and food waste sorting. The current system was evaluated using

Predictors of length of stay in forensic psychiatry: The influence of perceived risk of violence.

This study describes the prevalence of adverse events and length of stay in forensic psychiatric patients with and without a restriction order. Detailed clinical and administrative information from medical records and written court decisions was gathered retrospectively from admission until discharge for a Swedish population-based, consecutive cohort of forensic psychiatric patients (n=125). The m

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The aim of perioperative antibiotic prophylaxis is the prevention of surgical site infections and urinary tract infections during urological procedures. The indication for antibiotic prophylaxis comprises several risk factors such as the degree of contamination of the operative site, duration of surgery, implantation of devices and comorbidities of the individual patient. In general this involves

The global met need for emergency obstetric care: a systematic review.

Of the 287 000 maternal deaths every year, 99% happen in low- and middle-income countries. The vast majority could be averted with timely access to appropriate emergency obstetric care (EmOC). The proportion of women with complications of pregnancy or childbirth who actually receive treatment is reported as 'Met need for EmOC'.

Model drug release from matrix tablets composed of HPMC with different substituent heterogeneity

The release of a model drug substance, methylparaben, was studied in matrix tablets composed of hydroxypropyl methylcellulose (HPMC) batches of the USP 2208 grade that had different chemical compositions. It was found that chemically heterogeneous HPMC batches with longer sections of low substituted regions and lower hydroxypropoxy content facilitated the formation of reversible gel structures at

Predictors of Sustained Reduction in Energy and Fat Intake in the Diabetes Prevention Program Outcomes Study Intensive Lifestyle Intervention

Background Few lifestyle intervention studies examine long-term sustainability of dietary changes. Objective To describe sustainability of dietary changes over 9 years in the Diabetes Prevention Program and its outcomes study, the Diabetes Prevention Program Outcomes Study, among participants receiving the intensive lifestyle intervention. Design One thousand seventy-nine participants were enrolle

Comparative toxicity of salts to microbial processes in soil.

Soil salinization is a growing threat to global agriculture and carbon (C) sequestration, but to date it remains unclear how microbial processes will respond. We studied the acute response to salt exposure of a range of anabolic and catabolic microbial processes, including bacterial (leucine incorporation) and fungal (acetate incorporation into ergosterol) growth rates, respiration and gross N min

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.

Background Eosinophils are pro-inflammatory cells implicated in the pathogenesis of asthma and atopy. Apoptosis has been proposed as a potential mechanism underlying the resolution of eosinophilic inflammation and studies have indicated the ability of interventions that induce human eosinophil apoptosis to promote the resolution of eosinophilic inflammation. Recently, the cyclin-dependent kinase (

What constitutes a health-enabling neighborhood? A grounded theory situational analysis addressing the significance of social capital and gender

Variations in health between neighborhoods are well known and the conceptualization of social capital has contributed to an understanding of how contextual factors influence these differences. Studies show positive health-effects from living in high social capital areas, at least for some population sub-groups. The aim of this qualitative study was to understand what constitutes a 'health-enabling