Process development, optimization and robustness analysis for chromatographic separation are often entirely based on experimental work and generic knowledge. This paper describes a model-based approach that can be used to am process knowledge and assist in the robustness analysis of an ion-exchange chromatography step using a model-based approach. A kinetic dispersive model, where the steric mass

Providing increased transmission speed, quality and an efficient spectrum utilization is crucial for high speed wireless services of today and the future. This thesis is a collection of papers that address an important step in that direction -- the utilization of the spatial domain of the wireless channel. Paper I provides a survey of the most important concepts in channel and radio propagation m

”Jag hoppas att jag får ha hälsan”, är ett uttryck som idag känns passé. Hälsa är inte längre något man ”har”, eller ens ”får”. Idag är hälsa något man ”gör”. Det är individens ansvar att ”göra” sin hälsa genom att äta rätt, motionera väl, hålla sig uppdaterad om vetenskapliga rön och nya behandlingsmetoder och inte minst – tro på sig själv. Hälsa är – åtminstone i den offentliga diskursen – beroe

The inverse spectral problem for the Laplace operator on a finite metric graph is investigated. It is shown that this problem has a unique solution for graphs with rationally independent edges and without vertices having valence 2. To prove the result, a trace formula connecting the spectrum of the Laplace operator with the set of periodic orbits for the metric graph is established.

Bioinformatics methods with subsequent verification by experimental data were applied to the structural investigation of the intracellular loop of the d-subunit of the nicotinic acetylcholine receptor (nAChR). Three complementary methods were used: prediction of secondary structure elements, prediction of ordered/disordered protein regions and prediction of short functional binding motifs. The out

Smooth muscle cell (SMC)-specific deletion of transforming growth factor beta (TGF-beta) signaling would help elucidate the mechanisms through which TGF-beta signaling contributes to vascular development and disease. We attempted to generate mice with SMC-specific deletion of TGF-beta signaling by mating mice with a conditional ("floxed") allele for the type 11 TGF-beta receptor (tgfbr2(flox)) to

Popular Abstract in Swedish I »operatörens blick« beskrivs ett projekt där möjligheter för IT-stöd i erfarenhetsöverföring undersökts inom ett område där konfrontationen mellan datorisering och yrkeskunnande är särskilt tydlig - operatörsarbete i processindustrin. Driftsstörningar av olika omfattning är ett kontinuerligt inslag i operatörsarbetet och snabba förändringar i risknivå är en central deStudies in process control automation show that manual control skills are important in handling situations where the automatic control system fails. The fact that these skills are particularly difficult to maintain and develop in automated production environments is usually described as one of the ironies of automation. This work explores new roles for computer support in developing and maintainin

Refillable polyester bottles, for example polyethylene terephthalate (PET) bottles, are known to interact with chemicals. Aroma compounds from a product can be absorbed by the bottle material, remain after washing and remigrate when the bottle is reused, resulting in off-flavour of the new product. A certified reference material has recently been approved with which the chemical and sensory inertn