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Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular
Baron Erland Nordenskiöld was born on July 19th, 1877. As a son of the great explorer Adolf Nordenskiöld he was predestined to follow the road of scientific pursuit. Moving from the field of the natural sciences to anthropology, Nordenskiöld took the chair as professor of "general and comparative ethnography" in the early 1920's. This position at the University of Gothenburg marked the beginning o
Popular Abstract in Swedish Inom sjukvården används strålning för att behandla cancer. Vid strålbehandling är det viktigt att man i förväg vet precis hur strålningen ska ges till patienten för att resultatet av behandlingen skall bli bra. Ett hjälpmedel som används för detta är ett datorprogram (dosplaneringssystem) som, med utgångspunkt från patientens anatomi, beräknar hur varje enskild patient Gel dosimetry is a new dosimetry method applied in radiation therapy. Gel dosimeters consist of a radiation sensitive gel, which can integrate absorbed doses from several radiation sources or beams. The dose to the gel can be evaluated by magnetic resonance imaging (MRI), a procedure that is the focus of the present thesis. A robust tool for the evaluation of the nonuniformity in MRI has been dev
The report compiles the results from the METRO-project. The different parts of the project; design fires, evacuation, integrated fire control, smoke control, extraordinary strain on constructions and fire- and rescue operations are presented separately. The most complicated and expensive part of the project was the performance of the large scale fire and explosion tests in the Brunsberg tunnel. T
The shot noise behavior of sequential tunneling through two vertically coupled quantum dots is studied by means of a master equation approach. In particular, we propose a mechanism to observe super-Poissonian shot noise in such a system. The crucial ingredient is the Coulomb interaction between electrons in individual quantum dots.
Abstract in Danish LÆRING I OG AF KLINISK PRAKSIS sigter mod at forberede og styrke både de professionsbachelorstuderende indenfor sundhedsområdet, primært sygeplejestuderende, i deres møde med de kliniske uddannelsessteder og de kliniske uddannelsessteders møder med de studerende. Bogen belyser en række udfordringer, som disse møder giver, og hvilke læringsmuligheder der opstår, når den studeren
Popular Abstract in Swedish Avhandlingens syfte är att söka kunskap om vilka faktorer som bidrar till uppfostringsanstaltens framgång som social institution och dess ständiga misslyckande som behandlingsorganisation. Jag försöker förstå varför organisationer som §12-hem och särskilda ungdomshem finns och vilken betydelse de har i vårt samhälle. Svaret på den frågan söker jag på tre sätt: genom attThe aim of the present study is to find the factors and conditions that generate the success of the reformatory as a social institution and, at the same time, its well-known failure as a treatment organization. I try to understand why organizations like the reformatory exist and what meaning they have in our society. I seek answers by exploring the birth of the reformatory in a historical perspect
En studie av tidsvinstens värde. Hur värderas den tidsvinst som tunneln genom Hallandsåsen förväntas medföra ur olika perspektiv?
Variability in fire regime at the continental scale has primarily been attributed to climate change, often overshadowing the widely potential impact of human activities. However, human ignition modifies the rhythm of fire episodes occurrence (fire frequency), whereas land use alters vegetation composition and fuel load, and thus the amount of biomass burned. It is unclear, however, whether and how
Popular Abstract in Swedish Mellan 0.3 och 2.1 % av alla barn föds med portvins fläckar (PWS). Till skillnad mot vissa andra kärlmissbildningar försvinner inte PWS utan tvärtom blir många mer blåröda och tjockare med åren. Majoriteten av patienterna upplever sig vara negativt psykosocialt påverkade av sitt PWS i jämförelse med jämnåriga. Dessa negativa upplevelser minskar efter behandlingarna.(Se This thesis covers 12 years of experience in treating patients with congenital capillary malformations, so called port wine stains (PWS). The wide variation in treatment response to laser therapy has developed a profound need for the development of objective devises to measure treatment outcome, so that the maximum effectiveness of therapy can be achieved without unnecessary treatments. The purpos
Currently, policy makers in Sweden are considering updating building regulations with respect to daylight provision. Given this context, the present paper aims to provide insight on the level of compliance of residential spaces when tested against five daylight performance criteria. These included the criterion currently in force in Sweden, the two performance criteria set by European Standard EN1
PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat ma
