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Antigen-binding sites dominate the surface properties of IgG antibodies

A new technique, liquid-liquid partition chromatography in an aqueous polyethylene glycol-dextran two-phase system, was used to detect differences in surface properties of antibodies with different antigen-binding sites. Employing well-characterized monoclonal IgG antibodies and Fab and Fc fragments thereof as well as chimeric IgG antibodies we found a remarkable relationship between structure of

A very short uranium-uranium bond: The predicted metastable U-2(2+)

Quantum chemical calculations, based on multiconfigurational wave functions and including relativistic effects, show that the U-2(2+) system has a large number of low-lying electronic states with S of 0 to 2 and Lambda ranging from zero to ten. These states share a very small bond length of about 2.30 angstrom, compared to 2.43 angstrom in neutral U-2. The Coulomb explosion to 2 U+ lowers the ener

Recordings of mucociliary activity in vivo: benefit of fast Fourier transformation of the photoelectric signal

Investigations of mucociliary activity in vivo are based on photoelectric recordings of light reflections from the mucosa. The alterations in light intensity produced by the beating cilia are picked up by a photodetector and converted to photoelectric signals. The optimal processing of these signals is not known, but in vitro recordings have been reported to benefit from fast Fourier transformatio

Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities

Matrilins are putative adaptor proteins of the extracellular matrix (ECM) which can form both collagen-dependent and collagen-independent filamentous networks. While all known matrilins (matrilin-1, -2, -3, and -4) are expressed in cartilage, only matrilin-2 and matrilin-4 are abundant in non-skeletal tissues. To clarify the biological role of matrilin-2, we have developed a matrilin-2-deficient m

Serotonin agents in the treatment of acquired brain injury

Background: The development of novel serotonin agents has led to an increased use of these medications throughout medical practice. An understanding of the basic pharmacological function of these agents is key to understanding their usefulness. Among persons with brain injury, serotonin agents have been used for the treatment of depression, panic disorder, obsessive-compulsive disorders, agitation

Inte ens en gång – en tautologisk talspråkskonstruktion.

I sydsvenskt talspråk används ofta den tautologiska konstruktionstypen ens en gång i stället för ens för att uttrycka emfas i förbindelse med negation. Det negativa polaritetsordet ens har tidigare undersökts i förbindelse med negationen inte (Waldmann 2002). Det visar sig i den studien att realisationen kan beskrivas utifrån Chomsky (1999). I de sydsvenska dialekterna verkar däremot konstruktione

Immune complexes, rheumatoid factors, and cellular immunological parameters in patients with giant cell arteritis

Circulating immune complexes were found in 2 of 15 patients with giant cell arteritis (GCA) by using a solid phase Clq enzyme linked immunoabsorbent assay (ELISA). The prevalence in controls was 5%. Rheumatoid factor could be demonstrated in 2 out of 27 patients and in 11% of the controls by using a similar ELISA technique. The prevalence of T cells in blood was similar in 25 patients with GCA and

Swedish men's experiences of becoming fathers to their preterm infants

PURPOSE: To describe Swedish men's experiences of becoming fathers to their preterm infants. DESIGN: A cross-sectional descriptive study. SAMPLE AND METHOD: Eight men participated in semistructured interviews with open-ended questions. The interviews were analyzed using manifest and latent content analysis. MAIN OUTCOME VARIABLES: The concepts of control and noncontrol. RESULT: The manifest analys

Excited states in Sn-103: Neutron single-particle energies with respect to Sn-100

Gamma-ray lines from Sn-103 have been identified for the first time using EUROBALL and ancillary detectors. The level scheme of Sn-103 has been established by means of particle-gated gamma gamma coincidences. The energy spacing between the g(7/2) and d(5/2) neutron single-particle orbitals is determined from the excited states in Sn-103.

Viscoelastic and histologic properties in scarred rabbit vocal folds after mesenchymal stem cell injection

Objective/Hypothesis: The aim of this study was to analyze the short-term viscoelastic and histologic properties of scarred rabbit vocal folds after injection of human mesenchymal stem cells (MSC) as well as the degree of MSC survival. Because MSCs are anti-inflammatory and regenerate mesenchymal tissues, can MSC injection reduce vocal fold scarring after injury? Study Design: Twelve vocal folds f

Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

In a randomized, double-blind study (n = 58) with parallel groups, the effects of diltiazem (mean dose 329 mg/day) and atenolol (mean dose 67 mg/day) on carbohydrate and lipoprotein metabolism in hypertensive patients were compared. The mean systolic blood pressure (SBP)/diastolic blood pressure (DBP) reductions in the supine position were similar and satisfactory, 9/11 and 11/9 mmHg during atenol

Numerical Modeling of Turbulent Combustion and Flame Spread

Theoretical models have been developed to address several important aspects of numerical modeling of turbulent combustion and flame spread. The developed models include a pyrolysis model for charring and non-charring solid materials, a fast narrow band radiation property evaluation model (FASTNB) and a turbulence model for buoyant flow and flame. In the pyrolysis model, a completely new algorithm