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The influence of joint degeneration on the biomechanical properties of calcified cartilage and subchondral bone plate at the osteochondral junction is relatively unknown. Common experimental difficulties include accessibility to and visualization of the osteochondral junction, application of mechanical testing at the appropriate length scale, and availability of tissue that provides a consistent r

Background: Cystic fibrosis (CF)-related diabetes (CFRD) is the most common extrapulmonary complication in CF. CFRD is associated with low lung function, but the underlying mechanisms are poorly understood. The aim of the present study was to compare airway inflammation and the airway proteome in people with CF (pwCF) with and without CFRD.Methods: Sputum samples from pwCF were analysed for neutro

Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and treatment resistant tumor cells derived from mesenchymal stem cells, with minimal expression observed in non-neoplastic tissues. We have developed a humanized monocl

This paper describes a measurement of the jet radius dependence of the dijet momentum balance between leading back-to-back jets in Formula Presented of Formula Presented collisions collected in 2018 and Formula Presented of Formula Presented collisions collected in 2017 by the ATLAS detector at the LHC. Both datasets were collected at Formula Presented TeV. Jets are reconstructed using the anti-Fo

BACKGROUND: Group 5 allergens, such as Phl p 5 of timothy grass, are major contributors to grass pollen allergy. Antibody 212597 specific for this allergen was recently isolated by single cell sequencing of bone marrow B cells of a grass pollen-allergic subject. This antibody, although subjected only to a low level of hypermutation resulting in six amino acid substitution across the heavy and ligh

Background: Pneumocystis jirovecii pneumonia (PCP) is a severe opportunistic infection affecting immunocompromised patients. Quantitative polymerase chain reaction (qPCR) is widely used for the detection of P. jirovecii in respiratory samples. However, the diagnosis of PCP remains challenging and the high prevalence of P. jirovecii airway colonisation complicates the interpretation of positive res

Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occurs physiologically during mammalian hibernation and is fully reversed upon arousal, offering a unique translational model to study tau metabolism. However, limited data exist on insoluble and soluble tau alterations during hibernation and on patterns of tau fragment concentrations in

Although organizational innovation capability plays a driver for the improvement of safety performance of High Reliability Organizations (HRO), knowledge management is a key link and important guarantee for them. However, there is no relevant research on how to achieve innovation of HRO through knowledge management. Previous research highlights that the dynamic and uncertain external environment o

The preparation of ultra-thin PtSn-alloyed layers by molecular beam epitaxy was studied using low-energy electron microscopy (LEEM) and micro-diffraction (μ-LEED). Deposition at a sample temperature of 435 °C initially results in the formation of a Pt3Sn/Pt(111) layer showing a (2 × 2) reconstruction. With continued Sn deposition, a Pt2Sn/Pt(111) layer develops, showing a (3×3)R30° reconstruction.

Co-speech head and eyebrow gestures often align with pitch accents in spoken language production, thereby likely instantiating what we could refer to as multimodal prominence. Indeed, when speech is perceived audio-visually, controlled experimental studies have shown that both pitch accents and head and eyebrow gestures, when independently manipulated, have sizable effects on perceived prominence.

Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To ad

Capacities for source localization in response to incidents involving radioactive materials are essential for effective, efficient response. In this context, the directional response of a detection system is of importance. Many solutions currently employed for source localization involve approaches that may be onerous with respect to cost, complexity and practicality for field operations. To avoid

Objectives: The objective was to explore if adverse events during radical prostatectomy for prostate cancer were associated with oncological outcomes. A further objective was to identify risk factors for adverse events. Methods: A post-hoc study nested in a prospective, controlled trial of radical prostatectomy by robot assisted laparoscopic or open retropubic approach in Sweden. Adverse events du

The IFMIF-DONES facility provides a very high intensity flux of neutrons for research on materials of future fusion reactors and other complementary applications. The generation of those neutrons is driven by stripping reactions between energetic deuteron particles and a liquid lithium jet. The requirements on the deuteron beam are to deliver a 40 MeV beam with a constant current of 125 mA. All th

Multiple cropping, the simultaneous cultivation of several crops in space or time, is a global practice essential for intensifying and diversifying agriculture. Despite its substantial impact on environmental and socioeconomic outcomes of farming, multiple cropping is hardly accounted for in assessments of global food production, sustainability, and climate impacts. Such studies, often relying on

Pancreatic cancer continues to be a major cause of cancer deaths worldwide. Characterizing the tumors of long-term survivors (≥5 years survival) would create opportunities in prognostic and therapeutic strategies. In this study, RNA sequencing data was used to identify differentially expressed genes (DEGs) in tumors of long-term survivors (LTS) vs short-term survivors (STS). Using LASSO-Cox regres

Recent self-reported and cross-sectional survey evidence documents high levels of mental health problems among PhD students. We study the relationship between PhD studies and mental health care utilization using Swedish administrative records of prescriptions for psychiatric medication for the full population of PhD students. We find that prior to starting their PhD studies, prospective students u