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Histological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histoloHistological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histolo

The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM) contains the main building blocks of both components. The ECM provides physical support and stability to the lung, and as such it has in the past been regarded as an inert structure. More recent research has provided novel insights revealing that the ECM is also a bioactive environment that orchestrates the cel

Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of a

This paper describes an ascending evacuation model based on physical work capacity, when exhaustion may play a key role during evacuation. The experiment was carried out on a stair machine (StairMaster, SM5, USA) which involved 13 male and 12 female subjects. Individual climbing speeds at 50 and 70 % of their maximal aerobic capacity (% VO2max) level (L1 and L2) were selected for 3 minutes, and 90

Research on very old people has shown that perceived aspects of home are important for health, but research on such associations in younger cohorts of older people is lacking. The aim of this study was to investigate whether perceived aspects of home were associated with psychological well-being among community-living people aged 67–70. Interview data were collected with 371 individuals living in

Large Eddy Simulation (LES) and experiment were employed to investigate the transient ignition and flame propagation process in a rearwall-expansion cavity scramjet combustor using combined fuel injection schemes. The compressible supersonic solver and three ethylene combustion mechanisms were first validated against experimental data and results show in reasonably good agreement. Fuel injection s

Background Perfluoroalkyl substances (PFASs) are bio-accumulative pollutants, and prenatal exposure to PFASs is believed to impact human foetal development and may have long-term adverse health effects later in life. Additionally, maternal cigarette smoking may be associated with PFAS levels. Foetal exposure has previously been estimated from umbilical cord plasma, but the actual concentration in

Access to clean and affordable energy is one of the cornerstones of the world’s society. Sincethe introduction of the internal combustion engine, diesel engines have become widely usedfor transportation in the commercial sector. These engines are attractive as they have lowfuel consumption, but are also associated with high emissions of air pollutants, such asNOX and soot. These emissions are direAccess to clean and affordable energy is one of the cornerstones of the world's society. Since the introduction of the internal combustion engine, diesel engines have become widely used for transportation in the commercial sector. These engines are attractive as they have low fuel consumption, but are also associated with high emissions of air pollutants, such as NO$_X$ and soot. These emissions a

The aim of this study is to understand mixed systems of two types of particles with different size and shape, quinoa starch granules (NQ) and cellulose nanocrystals (CNC), to stabilize oil-in-water (O/W) emulsions. This study considers the extent of Pickering stabilization with respect to which particle type dominates at droplet interfaces and how stability is affected by the addition of one parti

The broad range of applications of synchrotron and neutron scattering in the investigation of soft condensed matter is reviewed. Appropriate combinations of these techniques allow probing the structure and dynamics of these complex systems from sub-nm to micron size scales and picoseconds to seconds and longer time ranges. Applications include a myriad of systems such as polymers, colloids, surfac

Unsteady laminar convective fluid flow and heat transfer past two cylinders in tandem arrangement is investigated. Besides forced mixing by the natural vortex streets, extra imposed oscillating inlet velocity are considered. The lift and drag coefficients and Strouhal number for a single cylinder and their dependence on Reynolds number are also provided to validate the calculations with previous e

AbstractPhysical exhaustion can constrain human ascending work capacity and performance during emergency evacuation on stairs. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations during two different strategies: self-preferred pace in three different public stairways in the field, and controlled pace in a laboratory on a stair machin

Atmosfäriska partiklar (aerosoler) finns överallt i jordens atmosfär. Masskoncentrationen av dessa varierar kraftigt beroende på i vilken miljö man mäter. I stadsluft kan man uppmäta tiotals mikrogram per kubikmeter medan man i arktiska områden uppmäter nanogram per kubikmeter. Den kolhaltiga aerosolen utgör en betydande del av atmosfärsaerosolens massa och är känd för att påverka människors och dCarbonaceous aerosols are known to affect human health negatively and to affect the climate of Earth. As specific types of aerosols originate from specific sources, it is important to know the amount of aerosols emitted from each source. Aerosol source apportionment is an important tool in mitigating air pollution and improving air quality. The subject of this thesis was the evaluation and develop

In addition to the nucleus, mitochondria and chloroplasts in plant cells also contain genomes. Efficient DNA repair pathways are crucial in these organelles to fix damage resulting from endogenous and exogenous factors. Plant organellar genomes are complex compared to their animal counterparts and although several plant-specific mediators of organelle DNA repair have been reported, many regulators

Mitochondria are crucial for plant viability and are able to communicate information on their functional status to the cellular nucleus via retrograde signalling, thereby affecting gene expression. It is currently unclear if retrograde signalling in response to constitutive mitochondrial biogenesis defects is mediated by the same pathways as those triggered during acute mitochondrial dysfunction.

Previous studies have identified a range of transcription factors that modulate retrograde regulation of mitochondrial and chloroplast functions in Arabidopsis (Arabidopsis thaliana). However, the relative importance of these regulators and whether they act downstream of separate or overlapping signaling cascades is still unclear. Here, we demonstrate that multiple stress-related signaling pathway

Mitochondria produce ATP via respiratory oxidation of organic acids and transfer of electrons to O2 via the mitochondrial electron transport chain. This process produces reactive oxygen species (ROS) at various rates that can impact respiratory and cellular function, affecting a variety of signaling processes in the cell. Roles in redox signaling, retrograde signaling, plant hormone action, progra

At12Cys-1 (At5g64400) and At12Cys-2 (At5g09570) are two closely related isogenes that encode small, twin cysteine proteins, typically located in mitochondria. At12Cys-2 transcript is induced in a variety of mutants with disrupted mitochondrial proteins, but an increase in At12Cys protein is only detected in mutants with reduced mitochondrial complex I abundance. Induction of At12Cys protein in mut

Plant organelle function must constantly adjust to environmental conditions, which requires dynamic coordination. Ca(2+) signaling may play a central role in this process. Free Ca(2+) dynamics are tightly regulated and differ markedly between the cytosol, plastid stroma, and mitochondrial matrix. The mechanistic basis of compartment-specific Ca(2+) dynamics is poorly understood. Here, we studied t

Programmed cell death (PCD) is crucial in plant organogenesis and survival. In this review the involvement of mitochondria and chloroplasts in PCD execution is critically assessed. Recent findings support a central role for mitochondria in PCD, with newly identified components of the mitochondrial electron transport chain (mETC), FOF1 ATP synthase, cardiolipins, and ATPase AtOM66. While chloroplas