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The neuronal endoplasmic reticulum (ER) contributes to many physiological and pathological processes in the brain. A subset of dendritic spines on hippocampal neurons contains ER that may contribute to synapse-specific intracellular signaling. Distribution of ER to spines is dynamic, but knowledge of the regulatory mechanisms is lacking. In live cell imaging experiments we now show that cultured h
Purpose: An increasing incidence and improved prognosis of kidney cancer have led to concern about second primary malignancies. The study of multiple primary malignancies is also important since the association of certain malignancies may guide the search for germline alterations and environmental risk factors. We evaluated bidirectional associations between renal cell carcinoma and other primary
Visualizing and measuring the gas distribution in close proximity to a working catalyst is crucial for understanding how the catalytic activity depends on the structure of the catalyst. However, existing methods are not able to fully determine the gas distribution during a catalytic process. Here we report on how the distribution of a gas during a catalytic reaction can be imaged in situ with high
Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation
The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD), compared with age-matched controls.
Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiogra
Measurements of Fourier transform infrared spectroscopy (FTIRS) in the mid-infrared (MIR) region were conducted on sedimentary records from Lake El'gygytgyn, NE Siberia, and Lake Ohrid, Albania/Macedonia. Calibration models relating FTIR spectral information to biogeochemical property concentrations were established using partial least squares regression (PLSR). They showed good statistical perfor
Abstract in UndeterminedA millimeter-wave (mm-wave) impulse radio is an attractive alternative to existing high-speed mm- wave radio systems because of the potential for a simpler transceiver architecture. This paper studies the feasibility of a mm-wave impulse radio system for home and office use by considering state-of-the- art transceivers and multiple-input multiple-output measured propagation
Popular Abstract in Swedish Vi utsätts varje dag för en stor mängd bakterier som skulle kunna göra oss sjuka, men för det mesta håller vi oss ändå friska. Epitelcellerna på hudens yta och på lungornas slemhinna bildar det första försvaret mot sjukdomsframkallande bakterier, dels genom att de utgör en fysisk barriär men också genom att de kan producera små bakteriedödande substanser, så kallade antEvery day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. They can either be constitutively produced or rapidly induced when epithelial
Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on
In this paper we demonstrate how surface site specific experimental information can be obtained from free low nanometer scale clusters using photoelectron spectroscopy utilising synchrotron radiation. In addition, we show how it can be used to gain insight into the geometry and surface structure of the clusters. The present experiments were conducted on alkali metal halides, RbCl and CsCl, which w
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Objectives To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial. Methods In the SWEFOT trial population, disease modifying antirheumatic drug (DMARD) naive RA patients started methotrexate; 3-month responders (DAS28 <3.2) continued (n=147), while non-responders were randomised to addition of sulfasalazine +hydroxychloroquine (n=130) or
Objectives: Rhinomanometry before and after decongestion distinguishes a nasal airway organic stenosis from congestion of nasal mucosa in patients with nasal stuffiness. Together with rhinoscopy and patient history, it is used to decide if nasal surgery would benefit the patient. Rhinomanometry measurements should thus be reliable and reproducible. Materials and methods: We performed repetitive ac
Aim. To establish the prevalence of restrictive eating problems, the overlap and association with attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorders (ASD) and to estimate the heritability of eating problems in a general population sample of twins aged 9 and 12. Methods. Parents of all Swedish 9- and 12-year-old twin pairs born between 1993 and 1998 (n = 12,366) were int
