The blood concentrations of lidocaine and its main active metabolites, methylethylglycinexylidide (MEGX) and glycinexylidide (GX), were measured in 24 newborn infants during anticonvulsive treatment with an iv infusion of lidocaine. After a bolus dose of 1.5-2.2 mg/kg and continuous infusion of lidocaine (4.7-6.3 mg/kg/h) there was accumulation of the drug and MEGX within 24 h. After termination o

BACKGROUND AND AIMS: Orlistat, a lipase inhibitor, strongly inhibits the activities of all gastric/pancreatic lipases except pancreatic phospholipase A(2)in vitro. In clinical use, for obesity treatment, it induces a variable degree of weight loss and steatorrhoéa. The aim of this study was to examine the degree of in vivo inhibition of individual gastric/pancreatic lipases by Orlistat in man, whe

OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, an

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a di

Possible deep (more than an inner third of the uterine wall) myometrial invasion and cervical extension of endometrial carcinoma were evaluated prospectively using magnetic resonance (MR) and transabdominal real-time sonography (US) in 20 and 10 patients, respectively. The data obtained from these examinations were compared with hysterosalpingography (HSG) and clinical modalities including hystero

Most of the world's energy generation is based on fossil fuels such as coal and oil, which already today but even more in the future, will cause various problems. One issue is their limited availability, which stands in conflict to the increasing global energy consumption. Another problem is the carbon dioxide generation caused by burning fossil fuels for energy production, and is thought to be on

The objective was to study the development and progression of heart disease in type 2 diabetic patients and to evaluate the influence of revascularisation procedures on its outcome. A 10-year observation study in 385 patients attending a hospital-based outpatient clinic was performed. A total of 156/385 patients developed myocardial infarction (n=68), angina (n=44), heart failure (n=34) or died (n

The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s

The administration and management of organizations and companies is based upon the belief in the rationality of certain ideas Ð here referred to as management ideas Ð that is, the belief in these ideas1 ability to solve problems and provide opportunities for betterment. The talk of and writings on management ideas (lexis) constitute discursive formations that precede and shapes practices (praxis),

Likhet inför lagen, som utgör de etniska minoriteternas mest grundläggande skydd mot maktövergrepp och etnisk diskriminering, ifrågasattes i Rodney Kings rättegång i Simi Valley 1992. Detta utlöste en rad kravaller som lämnade spår efter sig av blod och förstörelse. Kravallernas vådsamma karaktär var en reaktion på vad de svarta betraktade som det vita etablissemangets rättsövergrepp mot dem.

The self-assembled gold nanoparticle film deposited from the liquid-liquid interface has been fabricated, and homogeneous surfaceenhanced Raman scattering (SERS) of R6G molecules on the film has been observed. The SERS enhancement factor of the film is estimated to be in the range 10(8)-10(10). Occasionally, there are some sudden jumps in the Raman signal, where the signal is increased a few times

Whether elderly people in the final period of life have a high quality of life (QOL) and what factors relate QOL in this context, is not well known. The aim of this study was to examine the final period in life in elderly people (75 years or older) in need of help with instrumental activities of daily living (ADL), with the focus on quality of life, sense of coherence (SOC), health complaints and