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The contiguity and phase of sequence information are intrinsic to obtain complete understanding of the genome and its relationship to phenotype. We report the fabrication and application of a novel nanochannel design that folds megabase lengths of genomic DNA into a systematic back-and-forth meandering path. Such meandering nanochannels enabled us to visualize the complete 5.7 Mbp (1mm) stained DN

High and low pollen deposition years in the period 1998-2010 were recorded for ten forest-forming trees in Roztocze (SE Poland) using Tauber-style traps. The coincidence of very high/low pollen deposition years recorded in Tauber traps and aerobiological data obtained by volumetric samplers shows that these phenomena occur simultaneously in different places across vast areas of a tree's distributi

Context. The first release of astrometric data from Gaia is expected in 2016. It will contain the mean stellar positions and magnitudes from the first year of observations. For more than 100 000 stars in common with the HIPPARCOS Catalogue it will be possible to compute very accurate proper motions due to the time difference of about 24 years between the two missions. This Hundred Thousand Proper

Palaeobiogeographical data on Cambrian trilobites obtained during the twentieth century are combined in this paper to evaluate palaeoceanographic links through c. 30 myr, once these arthropods biomineralized. Worldwide major tectonostratigraphic units are characterized at series intervals of Cambrian time and datasets of trilobite genera (629 for Cambrian Series 2, 965 for Cambrian Series 3, and 8

Popular Abstract in Swedish Nivån på arbetsproduktivitet är särskilt betydelsefull i utvecklingsländer där det mesta av byggnadsarbetet utförs manuellt. Tidigare forskning har konstaterat att produktiviteten i byggindustrin är låg och i några fall sjunkande. Bristande produktivitet hos byggnadsarbetarna är en orsak till kostnadsöverskridande och förseningar av byggprojekt. Syfte med detta forskninProductivity of labour is particularly important especially in developing countries where most of the building work is still carried out on manual basis. Previous research has pointed out that productivity in the building industry is low and in some cases declining. Poor productivity of craftsmen is one of the causes of cost and time overruns on building projects. The objective of this research wa

In order to preserve the variety of life on Earth, we must understand it better. Biodiversity research is at a pivotal point with research projects generating data at an ever increasing rate. Structuring, aggregating, linking and processing these data in a meaningful way is a major challenge. The systematic application of information management and engineering technologies in the study of biodiver

In photonuclear experiments precise location of the photon beam relative to the experimental sample is critical. Previously used techniques such as using photographic film to identify the position, intensity and centroid of the beam is time-consuming and a faster method is required. PILATUS is a single-photon-counting pixel detector developed at the Paul Scherrer Institute (PSI), Switzerland. It i

Background: Physical inactivity presents a major public health challenge and is estimated to cause six to ten percent of the major non-communicable diseases. Studies show that immigrants, especially women, have an increased risk of non-communicable diseases compared to ethnic Swedes. Somali immigrant women have increased rates of overweight and obesity, low fitness levels and low levels of cardior

Background While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits. Methods In this study, s

The purpose of this study is to carry out updated and developed life cycle assessments of biofuels produced and used in Sweden today. The focuses are on making the assessments as relevant and transparent as possible and to identify hot spots which have significant impacts on the environmental performance of the specific biofuel production chains. The study includes sensitivity analyses showing the

The Paleoproterozoic part of the Fennoscandian Shield is composed of crustal components formed in different tectonic settings and generally separated by well-defined shear zone systems. An anomalous transitional boundary has been investigated by integrating structural analysis and geochronology with published geophysical data. The nature of this boundary is interpreted to be a consequence of an ap

The aim of this thesis was to conduct a prospective investigation of anxiety and its long-term effects on women referred for colposcopy after an abnormal cervical smear. The thesis comprises four articles, all based on a study of the current life situation, anxiety (Spielberger's state-trait anxiety inventory, STAI), depression (Montogomery Isberg Depression Rating Scale self-rate), psychosexualit

There are considerable expectations about the ability of genome-wide association (GWA) studies to make exciting discoveries about the role of genes in common diseases. GWA studies may allow researchers to identify causal pathways that have not been unveiled before, thus opening new avenues to disease understanding, prevention and therapy. However, there are still many open challenges. One is how t

In this Letter, we use a discrete polarizable solvation model for a systematic analysis of the solvent effects on the nitrogen NMR shielding and nuclear quadrupole coupling constants in a series of 1-methyltriazoles. Fairly accurate predictions are found for the solvent shifts of the nitrogen NMR shielding constants. The analysis of the relative half-height widths of the resonance signal predicted

Ontology organizes and formally conceptualizes information in a knowledge domain with a controlled vocabulary having defined terms and relationships between them. Several ontologies have been used to annotate numerous databases in biology and medicine. Due to their unambiguous nature, ontological annotations facilitate systematic description and data organization, data integration and mining, patt

Abstract is not available

T cells are crucial players in cell-mediated immunity. The specificity of their receptor, the T cell receptor (TCR), is central for the immune system to distinguish foreign from host antigens. Superantigens are bacterial toxins capable of inducing a toxic immune response by cross-linking the TCR and the major histocompatibility complex (MHC) class II and circumventing the antigen specificity. Here