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Vascular smooth muscle cells (SMC) endothelin type B (ET(B)) receptor upregulation results in strong vasoconstriction and reduction of local blood flow. We hypothesizes that the underlying molecular mechanisms involve transcriptional factor nuclear factor-kappaB (NF-kappaB) pathway. ET(B) receptor upregulation and activation of NF-kappaB were studied at functional contraction (in vitro myograph),

A test solution for a complex system requires the design of a test access mechanism (TAM), which is used for the test data transportation, and a test schedule of the test data transportation on the designed TAM. An extensive TAM will lead to lower test-application time at the expense of higher routing costs, compared to a simple TAM with low routing cost but long testing time. It is also possible

Abstract in UndeterminedPlans for the European Proteomics Association (EuPA) were conceived and established during 2004 and 2005, and culminated in the formal inception of the Organisation during the 4th HUPO World Congress held in Munich in 2005. The mission from the outset has been three-tiered and is to: i) strengthen the national Proteomics organizations in their efforts; ii) to co-ordinate an

Phenotypically and functionally distinct progenitors and developmental pathways have been proposed to exist for fetally-derived B-1 and conventional B-2 cells. Although IL-7 appears to be the primary regulator of fetal and adult B lymphopoiesis in mice, considerable fetal B lymphopoiesis and postnatal B-cells are sustained in the absence of IL-7, and in man B-cell generation is suggested to be lar

Explantation of postnatal rat retinas is associated with degenerative events that show morphological similarities to human retinal degenerative disorders. The most evident morphological features are photoreceptor apoptosis involving caspase-3 and Müller cell activation. The purpose of the present study was to determine the content of protective factors in rat retinal progenitor cells and analyze t

A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have be

A method is presented in which fracture mechanics is introduced into finite element analysis by means of a model where stresses are assumed to act across a crack as long as it is narrowly opened. This assumption may be regarded as a way of expressing the energy adsorption GC in the energy balance approach, but it is also in agreement with results of tension tests. As a demonstration the method has

This study was performed to compare the diagnostic quality of Gadofosveset-enhanced magnetic resonance venography with Gadobutrol-enhanced magnetic resonance venography and computed tomography venography for the deep veins of the lower extremities in patients with iliocaval venous pathology.

Background: Recent studies show that FVIIa binds to endothelial cell protein C receptor (EPCR) on vascular endothelium; however, the importance of this interaction in hemostasis or pathophysiology is unknown. Objective, The aim of the present study is to investigate the role of FVIIa interaction with EPCR on the endothelium in mediating FVIIa transport from the circulation to extravascular tissues

The present study tests the theoretical claim that Eurosceptics contribute to the Europeanization of national public spheres. Although advocating a renationalization of European politics, Eurosceptic parties can engender public media debates of transnational or European relevance. Through a comparative research design of two national cases (Sweden and Denmark), we examine the public discourse on t

The optogenetic approach to gain control over neuronal excitability both in vitro and in vivo has emerged as a fascinating scientific tool to explore neuronal networks, but it also opens possibilities for developing novel treatment strategies for neurologic conditions. We have explored whether such an optogenetic approach using the light-driven halorhodopsin chloride pump from Natronomonas pharaon

PURPOSEWe developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors. PATIENTS AND METHODSWe used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chem

The study inquires into how a specific piece of standardised information, namely the standard for bystander cardiopulmonary resuscitation (CPR), is configured in the practices of lifesaving and bystander CPR-training. Standardisation is commonly thought of as leading to uniformity and order, while practices are dynamic. They evolve and change through repeated enactments. The aim of this thesis is

Abstract Body composition measurements are used to evaluate surgical treatment, such as bariatric surgery in over weight patients. Nowadays, there are many different methods to measure body composition available. However, none of them has been validated for use in patients after operation. The aim of the present study was to compare the amount of surgically removed fat with two different methods,

To describe activity in different aspects of daily life among long-term stroke survivors, and conceptualise the content of the Barthel Index (BI) and the Swedish extended and modified Frenchay Activities Index (mFAI) using the ICF framework.

This paper presents arguments for a re-analysis of the b-prefix in Gulf Arabic dialects. Similar to several other dialects, Gulf Arabic possesses a b-prefix that is inserted before the p-stem (prefix form) of the verb. However, the Gulf Arabic b-prefix differs substantially from the one encountered in other Arabic dialects. According to most previous studies, the Gulf Arabic b-prefix encodes futur

To evaluate construct validity, internal consistency and inter-rater reliability of the Posture and Postural Ability Scale for children with cerebral palsy.

Clinicians may record patients presenting with osteoarthritis (OA) symptoms with joint pain rather than an OA diagnosis. This may have implications for OA research studies and patient care. The objective was to assess whether older adults recorded with joint pain are similar to those with a recorded OA diagnosis.