Phosphorylation is a common post-translational modification among intrinsically disordered proteins and regions, which helps regulate function by changing the protein conformations, dynamics, and interactions with binding partners. To fully comprehend the effects of phospho-rylation, computer simulations are a helpful tool, although they are dependent on the accuracy of the force field used. Here,

In this work we investigate the NLO QCD+EW corrections to the top quark pair production and their effects on the spin correlation coefficients and asymmetries at fixed-order top quark pair production and LO decay in the dilepton channel, within the narrow-width approximation. The spin correlations are implicitly measured through the lepton kinematics. Moreover we study the EW effects to the lepton

Information-to-energy conversion with feedback measurement stands as one of the most intriguing aspects of the thermodynamics of information in the nanoscale. To date, experiments have focused on feedback protocols for work extraction. Here we address the novel case of dissipation reduction in nonequilibrium systems with feedback. We perform pulling experiments on DNA hairpins with optical tweezer

Context. Despite swift progress in the characterisation of exoplanet atmospheres in composition and structure, the study of atmospheric dynamics has not progressed at the same speed. While theoretical models have been developed to describe the lower layers of the atmosphere, and independently, the exosphere, little is known about the intermediate layers up to the thermosphere. Aims. We aim to prov

Where is the world really heading, and what can we do about it? This book, edited by the Arkbound Foundation, takes an unflinching look at climate change – drawing upon the latest data to analyse what the next decades hold in store. With atmospheric CO2 at unprecedented levels and insufficient action being taken to prevent a rise in temperatures above 2 degrees centigrade, we are not just looking

The trophic structure of food webs is primarily determined by the variation in trophic position among species and individuals. Temporal dynamics of food web structure are central to our understanding of energy and nutrient fluxes in changing environments, but little is known about how evolutionary processes shape trophic position variation in natural populations. We propose that trophic position,

Functional traits mediate the response of communities to disturbances (response traits) and their contribution to ecosystem functions (effect traits). To predict how anthropogenic disturbances influence ecosystem services requires a dual approach including both trait concepts. Here, we used a response–effect trait conceptual framework to understand how local and landscape features affect pollinato

There is an increasing recognition that, although the climate change and biodiversity crises are fundamentally connected, they have been primarily addressed independently and a more integrated global approach is essential to tackle these two global challenges. Nature-based Solutions (NbS) are hailed as a pathway for promoting synergies between the climate change and biodiversity agendas. There are

We analyse the evolution of mortality rates in Spain by age and gender between 1990 and 2018. We compare municipalities, ranked by socio-economic status (SES) and grouped into bins of similar population size, to study changes not only in levels but also in inequality in mortality across the SES spectrum. We document large decreases in mortality rates throughout the period for all age groups, inclu

Although there is a large gap between Black and White American life expectancies, the gap fell 48.9% between 1990 and 2018, mainly due to mortality declines among Black Americans. We examine age-specific mortality trends and racial gaps in life expectancy in high- and low-income US areas and with reference to six European countries. Inequalities in life expectancy are starker in the United States

Background Colorectal cancer is a leading cause of cancer related death worldwide. 20-30 % of patients will develop colorectal liver metastases (CRLMs). Surgical resection is the mainstay of treatment for CRLMs, and is often combined with perioperative chemotherapy, which can prolong progression-free survival after resection. Moreover, observation of CRLMs response to preoperative chemotherapy can

For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem, we introduce persistent homology as a rigorous framework that can be used to both define For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem,we introduce persistent homology as a rigorous framework that can be used to both define a

Petroleum, contains proportions of contaminants such as sulfur, nitrogen, oxygen, and metals, such as nickel, iron, copper, sodium, and vanadium. Particularly, contaminants containing sulfur cause problems during handling, transportation, and the use of the their derivatives. This work had the goal of cracking the heavy crude oil molecules by reacting these molecules with tetralin and simultaneous

In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yi

Aim: The aim was to determine body composition and growth in preterm infants based on two different feeding regimens and to assess how standard and individual fortification (IF) affect energy and protein intake. Body composition was assessed at full term and at four months corrected age. Methods: Sixty preterm infants born before gestational week 32 were randomized either to IF of mother’s breast

Emissions from aviation are expected to grow. With evidence that the International Civil Aviation Organization’s Carbon Offsetting and Reduction Scheme for International Aviation is an inadequate mitigation mechanism, there is interest in upscaling the sector’s climate-related policies. This paper reviews potential aviation emissions mitigation policies against the background of emerging complexit

Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due to an underlying disease of the myocardium leading to disruption of the balance between tethering and closing forces with ensuing failure of leaflet coaptation. In patients with heart failure (HF) and left ventricular dysfunction, secondary MR is independently associated with poor outcome, yet prognostic ben

Atherosclerosis is a lipid-driven, chronic inflammatory disease. In spite of efficient lipid lowering treatments, such as statins and PCSK9 inhibitors, patients, especially those with elevated inflammatory biomarkers, still have a significant residual cardiovascular disease risk. Novel drugs targeting inflammatory mediators are needed to further reduce this residual risk. Agonistic immune checkpoi