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Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype

Background. Some autoimmune and chronic inflammatory disorders are associated with increased risks of non-Hodgkin lymphoma (NHL). Because different NHL subtypes develop at different stages of lymphocyte differentiation, associations of autoimmune and inflammatory disorders with specific NHL subtypes could lead to a better understanding of lymphomagenic mechanisms. Methods: In a population-based ca

Assessment of fracture risk

The diagnosis of osteoporosis is based on the measurement of bone mineral density (BMD). There are a number of clinical risk factors that provide information on fracture risk over and above that given by BMD. The assessment of fracture risk thus needs to be distinguished from diagnosis to take account of the independent value of the clinical risk factors. These include age, a prior fragility fract

Current molecular understanding of Axenfeld-Rieger syndrome.

Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant inherited disorder affecting the development of the eyes, teeth and abdomen. The syndrome is characterised by complete penetrance but variable expressivity. The ocular component of the ARS phenotype has acquired most clinical attention and has been dissected into a spectrum of developmental eye disorders, of which open-angle glaucoma repr

Verification of soil carbon sequestration: Sample requirements

Reliable and effective verification of soil carbon sequestration is required for quantification of project-based greenhouse gas mitigation. Direct soil sampling is necessary for measurements at field level. In this study, soil samples from a semiarid agroecosystem of the Sudan were statistically analyzed to evaluate if changes in soil organic carbon (SOC) over time or space were detectable or not,

Acupuncture for pain relief during childbirth

BACKGROUND: There are few studies on acupuncture in childbirth despite the generally established analgesic effect of acupuncture treatment. METHODS: The analgesic effect of acupuncture during childbirth was assessed by comparing the need for other pain treatments (epidural analgesia using bupivacaine, pudendal nerve block, intramuscular meperidine, nitrous oxide/oxygen, intracutaneous sterile wate

Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems - Purification of the human type 1 11 beta-hydroxysteroid dehydrogenase

Recently developed aqueous two-phase systems based on non-ionic detergents and polymers are suitable for the separation of membrane proteins. Moreover, within this relatively membrane protein "friendly" environment, changes in temperature can be controlled and stabilizing agents may be added to ensure integrity of the target protein during isolation. Here, we use aqueous two-phase partitioning for

Kungamakt och bonderätt : om danska kungar och bönder i riket och i Göinge härad ca 1525-1640

Popular Abstract in Swedish Under tidigmodern tid utvecklades på kronans gods i Danmark en interaktion mellan bönderna och överheten som byggde på intressegemenskap och en tvingande omsorgspraktik. Den nödvändiga samlevnaden mellan styrande och styrda utmärktes av interdependens och intersubjektiva lösningar på konflikter. Detta system framväxte som en nödvändighet för att minska effekterna av bönIn the early-modern period, Danish peasants living on crown estates across the country found a profitable way of interacting with the crown and its representatives. The necessary co-existence of rulers and ruled was marked by inter-dependence, solidarity of interest, and inter-subjective resolution of conflict. The system served to lessen the consequences of natural disasters that otherwise affect

Identitet och skillnad. Nedslag i likhetens problematik

Vad innebär (och hur kan man bestämma) begreppet ”likhet”, att någonting ”liknar” sig självt eller något annat, att det därmed kan ”identifieras”, att det vidare kan ”för-likas” med ett begrepp och underställas dess identitet? Vad innebär (och hur kan man bestämma) begreppet ”skillnad”, att någon-ting aktivt eller passivt ”skiljer” sig från någonting annat, att ”skillnaden” utesluter och separerar

By how much does increased nuchal translucency increase the risk of adverse pregnancy outcome in chromosomally normal fetuses? A study of 16 260 fetuses derived from an unselected pregnant population.

Objective: In this study we aimed to estimate the magnitude of a possible increase in risk of adverse outcome in fetuses with normal karyotype and increased nuchal translucency (NT), and to determine bow well NT measurements can distinguish between fetuses with normal and adverse outcome. Methods: We studied 16260 consecutive fetuses with normal karyotype derived from an unselected pregnant popula

Folding of S6 structures with divergent amino acid composition: Pathway flexibility within partly overlapping foldons

Studies of circular permutants have demonstrated that the folding reaction of S6 from Thermus thermophilus (S6(T)) is malleable and responds in an ordered manner to changes of the sequence separation between interacting residues: the S6(T) permutants retain a common nucleation pattern in the form of a two-strand-helix motif that can be recruited from different parts of the structure. To further te

Genetics of gestational diabetes mellitus.

About 2-5% of all pregnant women develop gestational diabetes mellitus (GDM) during their pregnancies and the prevalence has increased considerably during the last decade. GDM is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. It is manifested when pancreatic beta cells are no longer able to compensate for the increased insulin

Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus.

Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (C

Experimental excursions on adaptive landscapes: Density-dependent selection on egg size

Theories of density-dependent natural selection suggest that intraspecific competition will favor juveniles of high competitive ability. Empirical evidence has been provided from laboratory selection experiments, but field studies are lacking due to the logistical difficulties of experimentally manipulating population densities in natural settings. Here, we present data from a decade long experime

Canavanine content of sword beans (Canavalia gladiata) – analysis and effect of processing

The amino acid canavanine is a potentially toxic constituent of leguminous seeds. The aim of the present study was to determine the ability of different processing methods to reduce canavanine in sword beans (Canavalia gladiata). For this purpose a method for the detection and quantification of canavanine was developed using reversed-phase high-performance liquid chromatography of the dabsylated d

Holocene tephra horizons at Klocka Bog, west-central Sweden: aspects of reproducibility in subarctic peat deposits

This paper presents one of the most extensive Holocene tephra records found to date in Scandinavia. Microtephra horizons originating from Icelandic eruptions were recorded in two ca. 2 m thick peat profiles at Klocka Bog in west-central Sweden. Five of the microtephra horizons were geochemically correlated to the Askja-1875, Hekla-3, Kebister, Hekla-4 and Lairg A tephras respectively. Radiocarbon-

Combining information from range use and habitat selection: sex-specific spatial responses to habitat fragmentation in tawny owls Strix aluco

How individuals respond to habitat heterogeneity is usually measured as variation in range size and by ranking the relative importance of habitat types (habitat selection). The combined effect of how individuals incorporate different habitat types in their home ranges and allocate their time budget between them is rarely derived. Additionally, when home range size varies between individuals, habit

Glucose and insulin responses to porridge and gruel meals intended for infants

Objective: The objective was to determine the glycaemic index (GI) and insulinaemic index (II) of some common products intended for infants; that is, three commercial porridges and one gruel. Also, the influence of added fruit components to porridge on postprandial metabolic responses was studied by comparing corresponding data with a matched model product without fruit. Design: The volunteers wer