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Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally
Chiral Perturbation Theory is a useful tool to aid in performing the various extrapolations needed in lattice QCD calculations of physical quantities. These include extrapolations in quark mass, finite lattice spacing and finite size of the lattice. Especially the latter will becomemore important when the quark masses on the lattice become smaller. Here we develop the needed two-loop integrals at
The present status of Chiral Perturbation Theory (ChPT) in the strong mesonic sector is discussed. A very short introduction to ChPT is followed by an overview of existing two-loop calculations and the determination of the Low-Energy-Constants (LECs). I discuss the case of $\eta\to\pi\pi\pi$ decays in somewhat more detail and finish by mentioning some recent work on partially quenched ChPT and on
This review re-examines the use of accelerometer and oxygen uptake data for the assessment of activity intensity. Accelerometers capture mechanical work, while oxygen uptake captures the energy cost of this work. Frequency filtering needs to be considered when processing acceleration data. A too restrictive filter attenuates the acceleration signal for walking and, to a higher degree, for running.
Background: Informed consent is a prerequisite for patients included in clinical trials. Trial design, inclusion criteria and legal requirements are increasingly complex. This complexity challenges design and delivery of written and oral trial information to ensure understandable information. To evaluate the level of concordance between patients' and informing physicians' assessments regarding pat
Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. The mechanisms through which A. urinae cause infection are largely unknown. The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. Two proteins, denoted Aerococcal surface protein (A
