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A large outbreak of enterohaemorrhagic Escherichia coli (EHEC) infections occured in southern Sweden during autumn 2002. A matched case-control study was performed and indicated an association between consumption of fermented sausage and EHEC infection (odds ratio 5.4, P<0.002). Pulsed-field gel electrophoresis analysis identified a strain of E. coli O157:H7 in clinical faecal isolates which was i

Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (<2%

In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradic

We used the open-channel blocker, penicillin (10 mM), as a tool to investigate if the human α1β1 or α1β1γ2S γ-aminobutyric acid type A (GABAA) receptor channels opened in the absence of GABA. Application of penicillin to cells expressing the receptors resulted in a transient inward whole-cell current, the off-current, upon penicillin removal. The amplitude of the off-current was dependent on the d

Transmembrane (TM) alpha-helical peptides with neutral flanking residues such as tryptophan form highly ordered striated domains when incorporated in gel-state 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers and inspected by atomic force microscopy (AFM) (1). In this study, we analyze the molecular organization of these striated domains using AFM, photo-cross-linking, fluorescence spec

Popular Abstract in Swedish I denna studie har de grundläggande aspekterna på mass- och värmetransport i membrantekniken pervaporation studerats. Speciell tonvikt har lagts vid pervaporations användbarhet i samband med aromämnesåtervinning. Masstransporten i pervaporation påverkas av ett yttre masstransport- motstånd kallat koncentrationpolarisation. Detta fenomen kan orsaka att fluxen av de seleIn this study, the fundamental mass and heat transfer properties of the membrane separation process called pervaporation were investigated. The suitability of pervaporation for aroma compound recovery was especially evaluated. The mass transfer in pervaporation is affected by an external mass transfer resistance in the liquid feed boundary layer, i.e. the concentration polarization phenomenon. Th

We present time-resolved cross-correlation measurements of extreme ultraviolet (xuv) pulses generated as high-order harmonics of intense 35 fs pulses, using a short (12 fs) probe pulse. We modulate the ellipticity of the laser driving the generation process such that the polarization is linear for short times around the temporal peak of the pulse. Since harmonic generation is strongly suppressed f

The mechanisms of protein folding and aggregation are investigated by computer simulations of all-atom and reduced models with sequence-based potentials. A quasi local Monte Carlo update is developed in order to efficiently sample proteins in the folded phase. A small helical protein, the B-domain of staphylococcal protein A, is studied using a reduced model. In the thermodynamically favoured topo

Popular Abstract in Swedish Inom analytisk kemi är selektivitet en viktig fråga. Att kunna urskilja ett specifikt ämne av låg koncentration i ett komplicerat prov är viktigt inom t.ex. medicin, miljöanalys och livsmedelsindustri. Naturen har under miljontals år utvecklat selektiva system. Ett exempel på ett sådant system är antikropparna i människans immunförsvar; om ett främmande ämne kommer in iThe thesis is a bioelectrochemical study of heme enzymes, mainly peroxidases and cellobiose dehydrogenases (CDH). It covers both fundamental and applied aspects, viz. studies of the direct electron transfer and kinetics of enzymes on electrodes, and the development of amperometric enzyme-based biosensors. The kinetics of the direct and mediated electron transfer of a wide range of peroxidases (bo

Excited states of As-68 nucleus were populated through the C-12(Ni-58,pn) reaction and investigated by in-beam gamma-spectroscopic methods. The NORDBALL detector array equipped with charged particle and neutron detectors was used to detect the evaporated particles and gamma-rays. The level scheme of As-68 was constructed on the basis of gamma gamma-coincidence relations up to 6 MeV excitation ener

New radiative lifetimes, measured by time-resolved laser-induced fluorescence spectroscopy, are reported for five Rydberg states of singly ionized ytterbium. Free Yb+ ions were produced in a laser-induced plasma. The experimental results have been compared with HFR calculations, taking core-polarization effects into account, and a good agreement (within 25%) between theory and experiment is observ

BACKGROUND: Anal sphincter rupture is a serious complication of vaginal delivery and almost half the affected women have persistent defecatory symptoms despite adequate primary repair. During the past decade, the incidence of anal sphincter ruptures has been increasing in Sweden and is currently estimated to occur in 2.5% of vaginal deliveries. The aim of the study was to report the frequency of a

Objective: To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis was restricted to participants in the age group 50-64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centre

A collection of Cladosporium has been recovered from common reed growing at Lake Constance (Germany). High-resolution cryo-scanning electron microscopy revealed that Cladosporium isolates from reed are diverse. Morphologically, we distinguished three species, viz. C. herbarum, C. oxysporum, and Cladosporium sp. Internal transcribed spacer (ITS) sequence analysis supported these results and, moreov

Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second

Background - The aim of the study was to evaluate the relation between maternal placental Doppler velocimetry, levels of the maternal glucose, and clinical signs of vasculopathy in pregnancy complicated by pregestational diabetes mellitus. Methods and Results - A retrospective study of 155 pregestational diabetic women between the 22nd and 40th weeks of pregnancy, categorized in White classificati