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A genomic cosmid clone for human sex hormone binding globulin (SHBG), a liver-secreted plasma glycoprotein that binds sex steroids, was isolated with a previously characterized liver cDNA as probe. Southern blot analysis of genomic DNA indicated that only one SHBG gene is present in the human haploid genome. A 3.8 Kb Xba I-fragment of the clone containing the entire coding region of SHBG was seque

WHO estimated in 2002 that 1.4 million children in the world would die from preventable diseases (World Health Organization, 2010). Each child is, or should be, immunized according to their national immunization schedule, which regulates i.e. vaccines and doses. Problems emerge when immigrant children should be transferred from one national vaccination schedule into another. This problem is quite

Any diplomatic resolution of Iran’s nuclear controversy will deprive Israeli hawks of what they see as the sole feasible justification to overthrow the Iranian regime by military force.

Popular Abstract in Swedish Vi lever i en tid och i ett samhälle där kemikalier har blivit en naturlig del av vår industrialiserade vardag. Till stor del ligger kemikalieindustrin bakom flera av de stora tekniska framsteg som gör att västvärlden har den levnadsstandard den idag har. Tyvärr har den stora spridningen av icke naturligt förekommande kemikalier ibland också negativa effekter både på miThe modern world is increasingly dependent of the use of chemicals. The chemical industries have greatly contributed to the high standard of living in industrialised societies, and chemical compounds surround us in everyday life. Unfortunately, a vast number of chemicals cause adverse effects on the environment and human health. One such concern is chemical hypersensitivity, which is a state cause

This paper discusses the ethics underlying the occupational repertoire of the post-industrial citizen, giving attention to lifestyle phenomena such as increased tempo and quantity of occupations; manipulation of time, organisms and environments; decreases in sleep, rest and play etc. In trying to understand human behavior in the 21st century, an ethical perspective is delineated and some starting

Hemopoietic stem cells (HSCs) are maintained at relative quiescence by the balance between the positive and negative regulatory factors that stimulate or inhibit their proliferation. Blocking the action of negative regulatory factors may provide a new approach for inducing HSCs into proliferation. A variety of studies have suggested that TGF-beta negatively regulates cell cycle progression of HSCs

Performance of computer-based systems may depend on many different factors, internal and external. In order to design a system to have the desired performance or to validate that the system has the required performance, the effect of the influencing factors must be known. Common methods give no or little guidance on how to vary the factors during prototyping or validation. Varying the factors in a

Background: Iceland's geographical isolation with a stable and small population gives a rare opportunity for follow-up studies of medical interventions. Total hip replacements (THR) have been done at FSA Central Hospital in Akureyri, Iceland since 1982 with the Exeter hip implant being in use from the beginning. Methods: Hospital records for all patients operated on with THR between 1982 and the e

We examine how to reliably exploit baseline diversity of a multichannel interferometric synthetic aperture radar (InSAR) system to overcome the layover problem. In practice, the baseline steering vectors will be imprecise, resulting in array miscalibration. We propose, a nonparametric multilook approach based on robust Capon beamforming (RCB), allowing for uncertainty in the steering vectors.

We followed 11 patients 3-15 years after a cemented mega total hip replacement for a proximal femoral bone tumor. 7/8 survivors had good function and only occasional pain. 1 hip had been revised because of deep infection and in 1 case the cup had been exchanged because of aseptic loosening. 2 patients had been operated on because of local recurrence of the tumor. At follow-up, 1 patient had radiog

Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and la

Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second

We derive stellar ages, from evolutionary tracks, and metallicities,from Strömgren photometry, for a sample of 5828 dwarf and sub-dwarfstars from the Hipparcos Catalogue. This stellar disk sample is used toinvestigate the age-metallicity diagram in the solar neighbourhood. Suchdiagrams are often used to derive a so called age-metallicity relation.Because of the size of our sample, we are able to q

In the present experiment we examined reality monitoring for socially sensitive and non-sensitive information relating to prejudice (negative and positive beliefs about an ethnic minority). At study, participants either imagined or perceived negative or positive attributes in connection with photographs of target individuals that clearly varied in ethnicity (non-western or western). At test, the t