The book comprises three parts: (1) a general presentation and analysis of the main relevant concepts: bioethics, human genetic engineering, eugenics, disability and, particularly, of the relations between these; (2) the analysis of two documents of the Council of Europe (the so called “Bioethics Convention” and its first protocol), and the reconstruction of the debates surrounding their primary c

Über sociale Differenzierung ist Georg Simmels erstes hauptsächlich der Soziologie gewidmetes Werk. Das Buch stellt Simmels Grundlegung der neuen Wissenschaft dar, ihrer Themen, Möglichkeiten, Grenzen, allgemeinen Begriffe und Annahmen. Soziale Differenzierung, Wechselwirkung, Individualisierung, Gruppe, Vergesellschaftung und Bewegung sind entscheidende, variable Begriffe dieses zwischen Grundleg

A heterocyclic chemical compound of formula (1) or (2) or a neutral or acidic salt thereof where the counter ion is LI+, Na+, K+, Mg2+, Ca2+, NH4+ or another pharmacologically acceptable positively charged inorganic or organic ion or any combination thereof. The compound contains B, Si, N, P, S or Se in the ring structure.

Introduction. Underage drinking is associated with poor mental health. Early detection for risky alcohol use is recommended,although less implemented in adolescent care. +e objective of this study was to investigate the prevalence of risky alcohol use andpsychiatric comorbidity. Methods. Over a nine-month period, 145 eligible adolescents admitted to the child and adolescentemergency unit in Malmo,

Affective and anxiety diagnoses are common in older people with intellectual disability (ID). The aim was to describe support and social services for older people with ID and affective and/or anxiety diagnoses, also to investigate in this study group the association between support and social services and frailty factors in terms of specialist healthcare utilisation, multimorbidity, polypharmacy,

The aim of this study was to describe the social care provided for different age groups of people with intellectual disability, 55 years or above, and to investigate the association between such care and frailty factors for those with diagnosed level of intellectual disabilities. Descriptive and logistic regression analyses were used. Commonest forms of social care among the 7936 people were Resid

Conjugate addition of lithium methylcyanocuprate to the titlealdehydes proceeded with high diastereoselectivity (d.e. 94%). Methyl lithium 1,2-addition, followed by Swern oxidation of the resultingalcohols, gave benzyl botryodiplodin and benzyl epi-botryodiplodin.Hydrogenolysis of the benzyl groups gave the enantiomeric pairs ofbotryodiplodin 10r and 10s and epi-botryodiplodin (9r and 9s).

1,2-Addition of 3,4-methylenedioxymagnesium bromide to 2-(R) and (S)-benzyloxy-2,5-dihydro-4-furancarboxaldehyde, followed by oxidation, gave the title ketones (3r and 3s). Conjugate addition of the anions of 3,4,5-trimethoxy- and 3,4-methylenedioxybenzaldehyde diphenylthioacetal to 3r and 3s and Raney-nickel desulfurisation, followed by hydrogenolysis under various conditions, gave the title lign

The chiral aldehydes (-)-(2S,5S)- and (-)-(2S,5R)-2-[[[dimethyl( 1,1,2-trimethylpropyl)silyl]oxy]methyl]-5-methoxy-2,5-dihydrofuran-3-carbaldehyde (2 and 4) were synthesized in 60 and 15% yield, respectively, by lithium bromide induced rearrangement of 6-O-silylated methyl 2,3- and 3,4-anhydro-a- and -d-D-hexopyranosides, obtained in two steps from methyl α- and β-D-glucopyranoside. Rearrangement

The title aldehydes (lr, 1s, 2, and 3) underwent virtually diastereospecific conjugate addition by lithium methylcyanocuprate. The bulkiness of the anomeric benzyloxy or methoxy groups direct the attacking nucleophile to the less hindered side of the furanosidic ring. The stereochemical outcome of the Diels-Alder additions of cyclopentadiene to lr and 1s was governed almost completely by the bulki

Baker's yeast phosphatases induced regioselective hydrolysis on phytic acid leading to D-myo-inositol 1,2,6-tris(phosphate) which was transformed in optically active (+)-D-3,4,5-tri-O-phenylcarbamoyl-myo-inositol.

4-Deoxy-4-fluoro-myo-inositol was prepared by means of DAST with retention of configuration due to the assistance of a neighbouring benzyl ether.

Connected Autonomous Vehicles (AVs) with Vehicle-to-Vehicle (V2V) communication are becoming an essential component of the transportation system. Self-driving cars have the potential to optimize the roads' traffic flow, fuel consumption and remove the possibility of human error and distractions. In these systems, all involved vehicles must be fully autonomous for maximum gain. However, a fully aut

Phosphorylation of 6-O-tritylated methyl α-D-mannopyranosidc followed by deprotection gives an analogue of α-trinositol having virtually similar orientation of the phosphate groups. Biological testing showed the analogue to be inferior with respect to pharmacological effects.