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Motivation Machine learning offers a powerful approach for building predictive models from high-dimensional molecular data. Omics technologies such as transcriptomics, proteomics, and metabolomics quantify thousands of molecules simultaneously, providing deep insights into disease biology. Integrating multiple modalities can enhance predictive performance, as shown in histology-omics and holter-om
Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or
Antipsychotics are mainly used for severe psychiatric disorders. Risperidone is the only antipsychotic approved for younger children. Aripiprazole is approved for older children, ziprasidone and lurasidone for adolescents. To describe paediatric utilisation of antipsychotic drugs in Sweden. Dispensations of antipsychotic drugs to children aged 5–17 years from 2008 to 2021 were analysed using the N
Taylor Swift is one of today’s most beloved songwriters, however, all aspects of her work are not recognised. Swift frequently references queerness, yet this is often overlooked. Previous scholarship focused on Swift and queerness has either centred around Swift’s support for LGBTQ+ causes or the subgroup of Swift’s fans who acknowledges and embraces her expressed queerness, but textual analysis o
Att bygga en proteinmodell, strukturbestämning av ett förmodat urokanatreduktas Kardiometabola sjukdomar som hjärtsvikt och typ 2 diabetes blir allt vanligare. Studier har lyckats hitta en länk mellan den mänskliga bakteriefloran och utvecklingen av sådana sjukdomar. En metabolit, imidazolpropionat (ImP), produceras av bakterier och kan tas upp samt transporteras via blodet. Väl i blodet kan den
In 2015, the United Nations General Assembly unanimously adopted the 2030 Agenda for Sustainable Development with 17 Sustainable Development Goals and 169 targets. This agreement sets a 15-year plan to steer the world towards a more sustainable and equitable trajectory. However, as we have passed halfway through this agenda, the world is far from achieving most goals within this timeframe. Such la
Objective: Psychosocial stress increases the risk for subsequent episodes of alcohol use disorder (AUD) and drug use disorder (DUD), with most studies assessing stress exposure by questionnaire or interview methods. We developed an environmental risk score (ERS) using multiple classes of stressful life events (SLEs) obtained from national Swedish registries. Method: We assessed, in the entire adul
In a recent paper, Fack et al. (2019, American Economic Review) convincingly argue and theoretically demonstrate that there may be strong incentives for students to play non-truth-telling strategies when reporting preferences over schools, even when the celebrated deferred acceptance algorithm is employed. Their statistical test also rejects the (weak) truth-telling assumption in favour of another
Strut-based structures, such as lattices, produced using additive manufacturing (AM) offer significant potential for applications requiring lightweighting and structural compliance. However, conventional Design for AM (DfAM) approaches often assume idealised material behaviour, which can be misleading for thin strut-based structures where geometric parameters and process-induced effects significan
Decoupling key intermediates’ adsorption via asymmetric 3d-5d-orbital hybridization overcomes the intrinsic scaling relation bottleneck, enabling rational design of high-performance, durable multifunctional electrocatalysts for anion exchange membrane water electrolyzers (AEMWEs) and Zn–air batteries (ZABs). Here, we reveal that asymmetric 3d-5d-orbital hybridization, engineered through the synerg
Energy security crises have historically been turning points for energy systems, exposing vulnerabilities, reshaping policy priorities, and boosting technological change. However, whether—and to what extent—such crises accelerate low-carbon transitions remains contested. This paper examines the effects of the 2022 energy crisis on the European Union (EU)’s energy transition, using policy analysis
Archaeology’s turn to digital documentation poses questions for the long-term preservation of archaeological data and their future re-use—questions that have relevance also for the debates about open science and data archivization in the natural and social sciences. In this paper, I investigate how the nexus of epistemology and digital materialities affect attempts to open up archaeological data f
Denna rapport analyserar framväxten av hundvänlig turism i Sverige och belyser dess betydelse för besöksnäringens utveckling. Studien visar att hunden i allt högre grad betraktas som en familjemedlem, vilket påverkar resenärers beteenden, val av destination och konsumtionsmönster. Hundägare utgör en reseaktiv och kommersiellt attraktiv målgrupp som främst reser inom Sverige och efterfrågar naturbaThis report analyses the emergence of dog-friendly tourism in Sweden and highlights its significance for the hospitality industry's development. The study shows that dogs are increasingly regarded as family members, influencing travellers’ behaviour, destination choices, and consumption patterns. Dog owners represent a travel-active and commercially attractive target group that primarily travels d
The potential for information and communication technology (ICT) to support the delivery of social services, and the possible benefits afforded, have been acknowledged in numerous studies. The many obstacles to the adoption and integration of ICT into social services have also been documented. This paper provides a summary of those issues as the backdrop to the description of a study conducted to
