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Background: C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown that cytosolic C3 protects pancreatic beta-cells from stress, by allowing cytoprotective autophagy, and that the same intracellular pool of C3 also protects beta-cells from cytokine-induced apoptosis. Methods: We now generated a beta-cell s

Background: Magnetic resonance imaging (MRI) has traditionally been preferred over computed tomography (CT) for segmentation of intracranial structures due to its superior low contrast resolution. However, a reliable CT-based segmentation could improve patient management when MRI is not practical. Despite advancements in CT imaging, such as enhanced tissue differentiation using virtual monoenerget

Integrerad riskhantering handlar om att hantera komplexa och sammanlänkade risker på ett sätt som överskrider traditionella stuprör och sektorsgränser. I en globaliserad värld, där samhällen är alltmer beroende av avancerad infrastruktur och påverkas av hot som klimatförändringar, pandemier och säkerhetspolitiska kriser, krävs bredare och mer samordnade arbetssätt. Internationella ramverk som FN:s

Context: Autoimmune hypothyroidism is a common endocrine disorder affecting 1% to 2% of the population in iodine sufficient areas. While levothyroxine is standard treatment, a substantial number of patients report persistent symptoms despite adequate treatment. The use of liothyronine as an adjunct to levothyroxine therapy has increased. The psychiatric characteristics of patients receiving liothy

Cardiovascular-kidney-metabolic (CKM) syndrome affects approximately 90% of US adults, arising from the convergence of metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). These conditions create self-reinforcing cycles of multiorgan damage, substantially increasing mortality risk. The American Heart Association’s 2023 staging framework stratifies CKM from stage 0

The discrete Fourier transform (DFT) is one of the most important algorithms commonly used in baseband processing. While traditional hardware implemen- tations like the Fast Fourier Transform (FFT) are highly optimized, they heav- ily suffer from the von Neumann bottleneck. To overcome this, performing the computations directly in memory using memristive crossbar arrays is a promising solution. Th

Träets inneboende motståndskraft mot svampnedbrytning studerades med hjälp av paste test metoden. Prover av tre olika träslag, rödgran (Picea abies), tall (Pinus sylvestris) och bok (Fagus sylvatica), maldes först till pulver och inokulerades sedan med två typer av rötsvampar, brunrötsvamp (Rhodonia placenta) och vitrötsvamp (Trametes versicolor). För att analysera hur olika modifieringsmetoder kaThe inherent resistance to fungal degradation of wood was studied using the paste test method. Samples of three different types of wood, Norway spruce (Picea abies), Scots pine (Pinus sylvestris) and European beech (Fagus sylvatica), were initially ground to a powder followed by being inoculated with two types of rot fungi, brown rot fungus (Rhodonia placenta) and white rot fungus (Trametes versic

Formkollapser är ett av de mest kritiska problemen inom stålgjutning med V-processen. Varje gång en gjutform ger vika innebär det en kassation av detaljen, vilket medför stora ekonomiska förluster. I detta examensarbete, utfört i samarbete med en partner i industrin, har vi undersökt sandens dolda egenskaper för att förstå varför stabiliteten i processen varierar och hur man kan stoppa slöseriet. This study, conducted in collaboration with a industrial steel foundry, investigates how variations in sand properties influence mold stability in the V‑process, a vacuum‑assisted molding technique used in steel casting. A mixed‑method approach was applied, combining analysis of historical data, laboratory permeability testing, personnel interviews, and data-driven permeability modeling to identif

BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 bioma

Out-of-pocket (OOP) expenditures for childbirth in Bangladesh have increased substantially, intensifying financial pressure on lower-income households. While wealthier groups historically bore higher delivery costs, recent trends indicate a narrowing gap in spending across socioeconomic strata. This study investigates the drivers of this convergence in delivery-related expenditures between 2014 an

BackgroundWomen’s empowerment may influence non-communicable disease (NCD) risk. However, evidence on these associations among women in Bangladesh remains limited. This study examined the associations between women’s empowerment and the prevalence of selected non-communicable conditions among ever-married reproductive-aged women in Bangladesh.MethodsData from the 2022 Bangladesh Demographic and He