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IL-25 has been implicated in the initiation of type 2 immunity and in the protection against autoimmune inflammatory diseases. Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice.

An audio paper on H e (a) r; a soundscape connected to ecology, acoustics and embodiment, drawing on encounters and what happens in the connection. A fluctuation between hear-here-hér*-her. Originating in a work for the ensemble Nordic Affect’s concert at Nordic Music Days 2016, the piece has now been developed into both a quadrophonic and stereo version of H e (a) r (2017/18). The work has been r

Inheritance of the apolipoprotein E (ApoE) ε4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of β-amyloid (Aβ) in AD, Down's syndrome, and normal aging. Aβ deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE ε4 genotype and the deposition

Problem definition: The increasingly informed customer will lead to an even greater demand for expertise and knowledge of marketers. Firms need to find new ways to utilize the informed customer as a co-creator of value by more proficiently analyzing behavior, both online and offline. An uncertainty lies in to which extent the operational standards of KIBS firms translate to their marketing and sal

Popular Abstract in Swedish Bröstcancer är den vanligast förekommande cancerformen hos kvinnor och årligen drabbas ungefär 6000 kvinnor i Sverige. I de flesta fall uppstår bröstcancer spontant, men viss ärftlighet ligger bakom ca 10 % fallen. Det finns kopplingar till faktorer som ökar risken för bröstcancer. Till riskfaktorer hör bl.a. långvarig exponering för hormoner: tidig mens och sent klimakUnrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. By overexpressing cyclin E in a cell line model system we demonstrate that the capacity of ce

This paper describes the performance evaluation of new Delta E detectors to be used as pre-cell hit detectors in living cell irradiation experiments at the Lund Ion Beam Analysis facility (LIBAF). Using these detectors with a thickness down to 4.15 mu m fabricated at Lund University, an experiment was setup in which Delta E-detectors were used together with a stop E-detector in a telescope system

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stres

Context. 55 Cnc e is a transiting super-Earth (radius 1.88 R⊕ and mass 8 M⊕) orbiting a G8V host star on a 17-h orbit. Spitzer observations of the planet's phase curve at 4.5 μm revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses

Per oltre quarant’anni, la scrittura della storia nei paesi dell’Europa orientaleè stata fortemente condizionata dagli imperativi ideologici e propagandisticidei regimi comunisti. La storia, più di ogni altra disciplina umanistica, offrivagiustifi cazioni, e quindi legittimità, al potere. Indagare il rapporto tra storia epotere in questo ambito signifi ca tanto addentrarsi nella storia dei sociali

The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed for therapeutic uses in the treatment of an increasing number of chronic neurological and neuromuscular disorders, in addition to cosmetic applications. The toxins act at the cholinergic nerve terminals thanks to an efficient and specific mechanism of