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Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. The most effective treatment for PD is the DA precursor, L-DOPA. Unfortunately, within a few years, L-DO
Under chronically elevated N deposition, N retention mainly occur at high soil C-to-N ratio. This may be mediated through soil microbes, such as ectomycorrhizal (EM) fungi, saprotrophic fungi and bacteria, and the aim of this study was to evaluate the relationship between soil microbes and forest floor C-to-N ratios. Soil samples from 33 Norway spruce (Picea abies (L.) H. Karst) forests in Denmark
Popular Abstract in Swedish För att cellerna i kroppen ska fungera krävs det att proteinerna i cellerna beter sig som de ska, dvs att de signalerar på ett korrekt sätt. Det finns en mängd olika signalvägar i en cell och lika många olika mekanismer som styr signalvägarna. Mycket av det som sker i cellen regleras på ett eller annat sätt utifrån cellens genetiska kod som finns i DNA. DNA:t innehållerAberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. We found that high PKCα levels correlate with poor pro
Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far from optimized. There are several factors that need to be addressed and standardized when improving the long-term success of an implanted electrode. We have chosen to focus on three key factors when
In this paper, we propose a design framework for distributed embedded control systems that ensures reliable execution and high quality of control even if some computation nodes fail. When a node fails, the configuration of the underlying distributed system changes and the system must adapt to this new situation by activating tasks at operational nodes. The task mapping as well as schedules and con
Essän gör en läsning av den persiska poeten Forough Farrokhzad och undersöker hennes röst och roll i iransk litterär kvinnofrigörelse, utifrån en parallell med svensk och europeisk kvinnlig poesi på 60-70-talet och den position/handling som Cixous kallar écriture féminine.
The function of proteins depends crucially on conformational motions. The characteristic times of these motions extend from sub-picosecond to seconds. No single experimental tool can cover the entire time range and provide all necessary parameters for a complete understanding. Moreover, without a solid understanding of the data evaluation it is easy to misinterpret the complex phenomena. Because p
The natural language that accompanies the accounting language in financial reports is not only a more or less accurate representation of the company but also, the authors argue, a response to explicit as well as implicit external demands, expectations, and accusations. Drawing on the notion of accounts (i.e., statements or responses that neutralize critique of not meeting expectations), the author
Objective. To evaluate outcome after radical cystectomy for primary bladder cancer in a large population-based material. Material and methods. Between 1997 and 2002 all patients treated with radical cystectomy within 3 months after diagnosis of primary bladder cancer without distant metastasis were retrieved through the Swedish Bladder Cancer Registry. A follow-up questionnaire was distributed to
The reconstruction of photons in the ATLAS detector is studied with data taken during the 2004 Combined Test Beam, where a full slice of the ATLAS detector was exposed to beams of particles of known energy at the CERN SPS. The results presented show significant differences in the longitudinal development of the electromagnetic shower between converted and unconverted photons as well as in the tota
The severe consequences of road tunnel fires have led researchers to investigate the best safety design methodology. Italy has the main tunnel network in Europe and consequently the importance of a definition of the optimal design standard is a key issue. This paper reviews the design of the means of egress from tunnels within the Italian Codes (analysing both prescriptive and performance-based ap
Using data for the period 1968–2001, this article assesses the influence of partner choice and origin country characteristics on the propensity of immigrants to naturalize in Sweden. Marriage to a foreign-born Swedish citizen increases the naturalization propensity, and its effect increases strongly when the spouse naturalizes during the same year. The analysis suggests that a lower level of civic
We examine the characteristics of high-order harmonics generated with 800 nm, 25 mJ, 160 fs laser pulses in an Ar gas cell with the objective of seeding a free electron laser. We measure the energy per pulse and per harmonic, the energy jitter, the divergence and the position stability of the harmonic beam. We perform ab initio numerical simulations based on integration of the time-dependent Schro
Various acrylates [E-phenylpropenoate, E-3(4'-nitrophenyl)propenoate, E-3(2',5'-difluorphenyl)propenoate, E-3(2'-thienyl)propenoate, E-3(4'-imidazolyl)propenoate or E-2,3-dimethylpropenoate] were successfully intercalated into Ca(II)Fe(III) layered double hydroxide (CaFe - LDH) verified by a range of instrumental methods. The possible arrangements for the organic anions were suggested on the basis
A search is presented for direct top squark pair production using events with at least two leptons including a same-flavour opposite-sign pair with invariant mass consistent with the boson mass, jets tagged as originating from -quarks and missing transverse momentum. The analysis is performed with proton-proton collision data at collected with the ATLAS detector at the LHC in 2012 corresponding to
