Search results

Streptococcus pyogenes, the most significant streptococcal species in clinical medicine, expresses surface proteins with affinity for several human plasma proteins. Here we report that kininogens, the precursors to the vasoactive kinins, bind to the surface of S. pyogenes. M protein, a surface molecule and a major virulence factor-in these bacteria, occurs in > 80 different serotypes. Among 49 str

BACKGROUND: Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understanding of the pathogenic mechanisms of the disease but, in contrast to nonbilharzia bladder cancer, BAC has rarely been the object of such scrutiny. In the present study, we aimed t

Intellectual capital has gained increasing attention concerning both research and more practically oriented applications during the past five years. Intellectual Capital and other knowledge management tools are topics that have emerged in the light of a broader trend of redirecting the foundation of competitive advantage from the company’s tangible assets to its intangibles such as knowledge base,

A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds b

Allochthonous substances, i.e. produced in terrestrial ecosystems, are known to fuel bacterial production in humic lakes. I observed that allochthonous carbon subsidizes bacteria even at high levels of phytoplankton biomass. In line with that, my results also show that dissolved organic carbon is largely constituted of terrestrial substances irrespective of lake characteristics. Since bacteria co

Accelerator mass spectrometry (AMS) is a world-wide spread technique and nearly 50 AMS laboratories exist today. The most widely spread application of AMS is for radiocarbon dating and an estimated total of nearly 100000 ¹⁴C samples are measured per year. Other isotopes used are ¹⁰Be, ²⁶Al, ³⁶Cl, ⁴¹Ca, ¹²⁹I. The number of these meas

The location of lipoprotein lipase activity in rat adipose tissue was studied using intact epididymal fat pads, isolated adipocytes, and lipoprotein lipase activity secreted from adipocytes as enzyme sources. The enzyme activities of these preparations were characterized by gel filtration. The method used for isolation of adipocytes had been modified to minimize activation of lipoprotein lipase du

The different roles played by small and large eddies in engine combustion were studied. Experiments compared natural gas combustion in a converted, single cylinder Volvo TD 102 engine and in a 125 mm cubical cell. Turbulence is used to enhance flame growth, ideally giving better efficiency and reduced cyclic variation. Both engine and test cell results showed that flame growth rate correlated best

Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of

A feature that distinguishes extreme-value contexts from more conventional statistical problems is that in the former we often wish to make predictions well beyond the range of the data. For example, one might have a 10-year sequence of observations of a phenomenon, and wish to make forecasts for the next 20 to 30 years. It is generally unclear how such long ranges of extrapolation affect predicti

The crystallization of a key enzyme from Aquifex aeolicus with suggested bifunctional activity, acting as an exopolyphosphatase and a guanosine pentaphosphate phosphohydrolase, is reported. Native data were collected to below 2 A resolution from an orthorhombic crystal with unit-cell parameters a = 50.8, b = 70.3, c = 90.9 A. Methionine residues were introduced by mutation and deliberate oxidation

Chemically skinned guinea pig taenia coli fibre bundles showed a concentration-dependent decrease in width when incubated in media containing Dextran T500 (0-0.2 g ml-1). The maximal reduction in width, observed at 0.2 g ml-1 dextran, was 32%. The effect was reversible upon removal of dextran. Isometric force was slightly increased (about 10%) at the lowest dextran concentration (0.025 g ml-1) but

Biomass gasification for energy or hydrogen production is a field in continuous evolution, due to the fact that biomass is a renewable and CO2 neutral source. The ability to produce biomass-derived vehicle fuel on a large scale will help to reduce greenhouse gas and pollution, increase the security of European energy supplies, and enhance the use of renewable energy. The Varnamo, Biomass Gassifica

In her widely cited and criticised Gender trouble, Judith Butler (1990) elaborated the thought that gender needs to be understood as performative – a certain kind of doing behind the bars of a hegemonic heterosexual imperative that governs intelligible bodily configurations. Drawing mainly on psychoanalytical and foucauldian arguments, Butler dwells upon numerous important questions concerning pow

I en ny stor, randomiserad interventionsstudie (ADVANCE) har man med aktiv behandling (perindopril/indapamid) jämfört med placebo nu fått otvetydiga resultat som visar att en skärpt blodtryckssänkning hos typ 2-diabetiker ger kliniska vinster. Vid en genomsnittlig tryckskillnad på 5,6/2,2 mm Hg (med ett medelblodtryck på 135/78 mm Hg i aktiva gruppen vid studiens slut) uppnåddes signifikanta effek