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OBJECTIVE: Autoantibodies have long been recognized as biomarkers of islet autoimmunity in type 1 diabetes, but their role in the pathogenesis is not fully understood. The aim of this study was to analyze clinical and hereditary characteristics of children presenting with and without autoantibodies at type 1 diabetes diagnosis.RESEARCH DESIGN AND METHODS: Data were collected from children (<18 yea
We have studied van der Waals contacts of the carotenoid rhodopin glucoside (RG) with the bacteriochlorophyll pigments absorbing at 800 nm (B800) in the crystal structure of Rhodopseudomonas acidophila, and the hydrogen positions were determined from quantum chemical calculations at the Hartree–Fock (6-31G) level. We have found strong evidence for hydrogen bonding between the B800 BChl and th
Excited state dynamics of antenna complexes in an LH2-only mutant of the purple bacterium Rb. sphaeroides have been investigated by means of two-color femtosecond spectroscopy combined with computer simulations. Measurements of transient absorption spectra revealed a new spectral band in the stimulated emission region around 880 nm at 6 K. To simulate this new dynamic feature that appears wit
Charge generation, injection and recombination in quantum dot-sensitized ZnO nanowires was probed using time resolved terahertz spectroscopy. The mobility spectrum at different representative pump-probe delays showed similar behavior during the injection time indicating free charges on the nanowire structures.
We have used approximately 40 fs pulses from a Ti:sapphire laser to investigate the ultrafast energy transfer and relaxation dynamics in the light-harvesting pigment-proteins of photosynthetic purple bacteria. Our results reveal two new features, not earlier observed in light-harvesting pigments: (1) ultrafast relaxation characterized by a time constant of approximately 20 fs, which we interpret a
Using ≈ 40 fs pulses we have observed coherent nuclear motions in intact membrane bound photosynthetic light-harvesting pigment-protein complexes. Computer simulations based on the harmonic Franck-Condon approximation and the Langevin equation describe qualitatively well the temperature and pulse wavelength dependence of the oscillations, indicating the possibility to observe higher harmonics of t
Objectives: Menstrual migraine (MM) is a debilitating neurological disorder triggered by fluctuations in ovarian hormones, particularly estrogen. While the calcitonin gene-related peptide (CGRP) system is central to migraine pathophysiology, the molecular mechanisms linking hormonal changes to CGRP signaling remain unclear. This study investigates how sex hormones regulate CGRP-related gene expres
Our relationships with others structure many aspects of our lives, especially during important moments such as choosing an education, entering the workforce, forming partnerships or starting a family. While the influence of family and parenting has been widely studied, less is known about the role of non-family connections, such as neighbours. One reason is that the data needed to study these rela
The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit
The influence of individual psychological and cognitive characteristics on preferences for value versus growth stocks (VSvGS) is not well understood. This study examines the influence of personality traits, financial self-efficacy (FSE), and versatile cognitive styles (VCS) on the choice between VSvGS. Specifically, it examines both the direct effects of personality traits on individual preference
HYPOTHESIS: Digestion pathways of plant proteins are of high relevance to optimize bioavailability and allergenicity profiles of sustainable and vegan food products. Understanding the structural breakdown of solid food presents a particular challenge, due to the complexity to realize a good model system suitable for comprehensive multi-technique characterization under realistic conditions.EXPERIME
HAVING STRONG BRANDS is a key to our success. One of our most important tasks for the future is therefore strengthening the Erisson brand. Our ambition is to further develop Ericsson – a brand that represents and projects reliability. This is a fundamental prerequisite if we are to increase our collective competitiveness, ability to grow, and profitability.1) The Ericsson Trademark Book:2) Tradema
This paper examines how the concept ‘nature-positive’ as a means to enhance biodiversity is defined and used, viewed through the lens of power. Building on a three-dimensional conceptualization of power, we elaborate on i) how ‘nature-positive’ enters and remains on business and policy agendas, ii) different interpretations from both ecological and business perspectives, and iii) the governance of
Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF α-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status
From June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, SvenskehuseFrom June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, Svenskehuse
A substantial external force transmitted to the brain may cause a severe traumatic brain injury (sTBI) , resulting in structural brain damage and/or functional impairment. Despite progress in management, traumatic brain injury remains a major cause of severe disability and death. This thesis evaluates treatment strategies and novel interventions in children and adults with sTBI and comprises the f
We report an unusual case of a patient presenting with Cushing’s syndrome caused by a phaeochromocytoma secreting adrenocorticotropic hormone (ACTH). The patient had a history of treatment-resistant hypertension, secondary amenorrhoea and tendency towards hypokalaemia. She had multiple signs of Cushing’s syndrome, such as swelling, bruising, abdominal striae and proximal myopathy. Hypokalaemia is
Transferring patients from the ward of their specialty or consultant is described as boarding. 1 Boarding patients is becoming increasingly prevalent due to greater pressure on hospital capacity. This practice compromises patient safety through delayed investigations, prolonged hospital stays, and increased risk of hospital-acquired infections. 1 2 We evaluated how regularly boarded patients were
