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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Here, to circumvent this

The geometric albedo of the hot Jupiter HD 189733b measured with CHEOPS

Context. Measurements of the occultation of an exoplanet at visible wavelengths allow us to determine the reflective properties of a planetary atmosphere. The observed occultation depth can be translated into a geometric albedo. This in turn aids in characterising the structure and composition of an atmosphere by providing additional information on the wavelength-dependent reflective qualities of

Temperature-induced DNA density transition in phage λ capsid revealed with contrast-matching SANS

Structural details of a genome packaged in a viral capsid are essential for understanding how the structural arrangement of a viral genome in a capsid controls its release dynamics during infection, which critically affects viral replication. We previously found a temperature-induced, solid-like to fluid-like mechanical transition of packaged λ-genome that leads to rapid DNA ejection. However, an

Discovery of TOI-1260d and the characterization of the multiplanet system

We report the discovery of a third planet transiting the star TOI-1260, previously known to host two transiting sub-Neptune planets with orbital periods of 3.127 and 7.493 d, respectively. The nature of the third transiting planet with a 16.6-d orbit is supported by ground-based follow-up observations, including time-series photometry, high-angular resolution images, spectroscopy, and archival ima

Reviewing value creation in agriculture—A conceptual analysis and a new framework

Creation of business value is a major objective of any enterprise, but the way in whichvalue is created and its consequences call for re-evaluation in response to current sustainability goals. The agricultural sector serves basic human needs, but its systems and methods for production, processing, and consumption often pose challenges to sustainable development. To address these challenges, this s

Sustainable value creation–a farm case on business model innovation

The agricultural sector in Sweden, as elsewhere, is affected by increased intensification and specialisation, leading to fewer and larger farms. The majority of agricultural firms acquire profits by pushing an economies of scale strategy, which is not always possible for small farms. However, there are alternative strategies. This teaching case focuses on a small farm in Sweden and offers students

We do it our way – small scale farms in business model transformation for sustainability

Value creation is at the core of business model (BM) research, but the link between BM and value creation remains unclear. In this work, empirical data on BM transformation towards sustainable value creation in the agri-food sector, were obtained through case studies. Factors in BM transformation were identified, transformations in different BM segments were analysed and sustainable value created

Perspectives on agroecological transition: the case of Guachetá municipality, Colombia

Specialization of agriculture in the Colombian Andes has increased smallholder vulnerability to climate change and global price fluctuations and has also affected the socio-economic and environmental conditions. Promoting sustainable agriculture in the region requires a holistic understanding of complex agroecosystems. This study identifies and analyzes the main challenges for agriculture and poss

Personalized diagnosis in suspected myocardial infarction

Background: In suspected myocardial infarction (MI), guidelines recommend using high-sensitivity cardiac troponin (hs-cTn)-based approaches. These require fixed assay-specific thresholds and timepoints, without directly integrating clinical information. Using machine-learning techniques including hs-cTn and clinical routine variables, we aimed to build a digital tool to directly estimate the indiv

Simulating Magnetized Plasma using an Accelerated Finite Element-Boundary Integral Code

This paper describes an accelerated finite element-boundary integral code with support for complex media. The code is implemented in Python using several open source packages, and uses Numba just-in-time compilation for improved performance. To accelerate the boundary integral part of the code, a multilevel implementation of the adaptive cross approximation is used. As a numerical example, scatterThis paper describes an accelerated finite element-boundary integral code with support for complex media. The code is implemented in Python using several open source packages, and uses Numba just-in-time compilation for improved performance. To accelerate the boundary integral part of the code, a multilevel implementation of the adaptive cross approximation is used. As a numerical example, scatter

Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Background: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) var

The dynamics of beamline configurations and user communities : Quantitative studies of Big Science publications

This thesis examines the role of beamlines with publication metadata from the European Synchrotron Radiation Facility (ESRF a large scientific facility offering diverse conditions for scientific research. As a user-oriented Big Science facility, the ESRF channels extremely brilliant light into different experimental areas called beamlines that house specific instruments that cater to the needs of

Directors’ duties during the Green Transition under EU law - Reform and ramifications from corporate sustainability due diligence

In response to the climate emergency, the European Union seeks to establish a new model of inclusive growth and depicts this shift as a ‘green, fair and competitive transition’. The article examines the EU sustainable corporate governance initiative commenced in 2018 that has crystalized after 4 years in a Commission’s proposal for a Directive on corporate due diligence, which is expected to be ad

Real-time detection of mAb aggregates in an integrated downstream process

The implementation of continuous processing in the biopharmaceutical industry is hindered by the scarcity of process analytical technologies (PAT). To monitor and control a continuous process, PAT tools will be crucial to measure real-time product quality attributes such as protein aggregation. Miniaturizing these analytical techniques can increase measurement speed and enable faster decision-maki

Making the Rule of Law Great Again: The Building of the Digital Rule of Law in the European Union

This chapter examines the legislative and judicial dimensions of the digital rule of law in the EU and its current and future building. We argue that adjudication in EU law related to the digital rule of law is destined to grow as it is fostered by the new legislation in digitalisation and a proactive Court of Justice eager to interpret the rights enshrined under the Charter. The building of the d