Although current LC-MS technology permits scientists to efficiently screen clinical samples in translational research, e.g., steroids, biogenic amines, and even plasma or serum proteomes, in a daily routine, maintaining the balance between throughput and analytical depth is still a limiting factor. A typical approach to enhance the proteome depth is employing offline two-dimensional (2D) fractiona

Background: Patients with CHD exhibit reduced isometric muscle strength and muscle mass; however, little is known how these parameters relate. Therefore, the aim was to investigate the relation between isometric limb muscle strength and muscle mass for patients in comparison to age- and sex-matched control subjects. Methods: Seventy-four patients (35.6 ± 14.3 years, women n = 22) and 74 matched co

Three species of the family Teloschistaceae (lichenized Ascomycota) are described as new to science from Southern and Eastern Siberia and the Far East. Corticolous Caloplaca saviczii belongs to the genus Caloplaca s. str.; it has C. cerina-like apothecia and green to grey-green, crateriform soralia with a white rim. Lendemeriella aureopruinosa is a saxicolous taxon with a thin grey thallus and sma

We here present a comparison of methods for the pretreatment of a batch of tree rings for high-precision measurement of radiocarbon at the Aarhus AMS Centre (AARAMS), Aarhus University, Denmark. The aim was to develop an efficient and high-Throughput method able to pretreat ca. 50 samples at a time. We tested two methods for extracting α-cellulose from wood to find the most optimal for our use. On

Background: Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau pathology. We compared the diagnostic value of both biomarkers in cognitively unimpaired participants and patients with a clinical diagnosis of mild cognitive impairment, Alzheimer's disease syndromes, or frontotemporal lobar degene

Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effec

The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited b

Understanding how and why some groups have become more species-rich than others, and how past biogeography may have shaped their current distribution, are questions that evolutionary biologists have long attempted to answer. We investigated diversification patterns and historical biogeography of a hyperdiverse lineage of Lepidoptera, the geometrid moths, by studying its most species-rich tribe Boa

Deficiencies of C2 and other components of the classical pathway of complement are associated with increased risk of infections with encapsulated bacteria, such as Haemophilus (H.) influenzae. Defense against H. influenzae is dependent on specific antibodies and complement, which mediate serum bactericidal activity (SBA) and opsonization. Due to lack of normal classical and lectin complement pathw

Objective: To assess whether adding prostate volume to the kallikrein panel improves discrimination for ISUP Grade Group 2 or higher (GG2+) disease, as some men may have volume measurements available at the time of blood draw. While prostate volume predicts biopsy outcome, it requires an imaging procedure for measurement. The four kallikrein panel - commercially available as the 4Kscore - predicts

Cities are experiencing numerous challenges, adversely affecting human health and wellbeing. Urban green space provides ecosystem services that are important to meet urban challenges. One type of urban green space is private gardens (yards) that make up an essential part of many urban areas. Gardens can support urban biodiversity and provide cultural ecosystem services (CES) to its owner. However,

The aim of the study was to investigate safety and if extracorporeal photopheresis (ECP) may change health criteria (HC) and quality of life (QoL). Material and method: 560 patients (33 % women) were treated with ECP for a total of 13,871 procedures during a 17-years period. Mean age was 48 years (±18, range 3−81 years). Self-estimation of QoL was graded: 0 (suicidal) up to 10 (best ever) and HC:

While communication of business ethics has increased in importance, it is often understood as being more of immaterial than material value. However, recent studies have demonstrated that language and communication can have important social consequences, changing institutional logics and daily practices in economic fields. This conceptual paper explores how sociologist Pierre Bourdieu’s theory of p

Taking as its starting point the scholarly discussion about the possible death of the Aesopic fable towards the end of the eighteenth century, this article proposes a broadening of perspective, arguing for a thorough examination of the impact of modernity on some of the basic contexts and conditions of the genre. Four contextual factors are, subsequently, placed under scrutiny: the ethics of virtuTaking as its starting point the scholarly discussion about the possible death of the Aesopic fable towards the end of the eighteenth century, this article proposes a broadening of perspective, arguing for a thorough examination of the impact of modernity on some of the basic contexts and conditions of the genre. Four contextual factors are, subsequently, placed under scrutiny: the ethics of virtu

Industrial production of probiotic bacteria must be adapted to reach a stable product with resistance to unfavourable environmental conditions during storage and that display probiotic functionality. Flow cytometry-based descriptors, light scatter and pulse width of bacterial morphology were used as markers to estimate physiological fitness. The effects of temperature, pH and oxygen levels on cell