Relative a absolute (pollen concentration) diagrams are presented from Bergebyvatnet, Holmfjellvatnet and Stjernevatnet on Varanger peninsula. All three sites are outside the younger Dryas (Main substage) moraines and the pollen assemblage zones are correlated biostratigraphically with chronozones from Allerød to Middle Flandrian. Radiocarbon dates from Bergebyvatnet appear to have been affected b

A relative and absolute (pollen concentration) diagram is presented from Østervatnet, southern Varanger peninsula, north of the Main sub‐stage (Tromsø‐Lyngen) moraines. The pollen assemblage zones are correlated biostratigraphically with chronozones from Bølling to Middle Flandrian. Sediment analyses (loss on ignition and particle size) and implied sedimentation rates support this chronology. The

North Hoy is an area containing a remarkable diversity of vegetation in a small area. A phytosociological account of the hill vegetation of North Hoy is presented, making use of an ordination method to clarify the inter‐relationships of the moorland vegetation types, as well as traditional methods. It has proved very interesting to compare the vegetation with the account of Scottish Highland veget

The Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with cutting-edge technology and now holds about six times more data (162 versus 24 entries and 242 vers

Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body m

Objectives: Clinical trials demonstrated that golimumab is effective in anti-TNF naïve patients with ulcerative colitis. We aimed to assess the clinical effectiveness of golimumab in a real-world setting. Materials and methods: This was a prospective cohort study, conducted at 16 Swedish hospitals. Data were collected using an electronic case report form. Patients with active ulcerative colitis, d

Forty-two years ago, Stephen Hawking made predictions that radiation does escape from black holes. Known as “Hawking radiation” this phenomenon is too weak to observe with current techniques, and remained the “Holy Grail” for astrophysics. It has remained as such until recently when researchers led by Professor Steinhauer at the Israel Institute of Technology observed radiation emanating from an a

En bakgrundsskildring av Österrike på 1930-talet, i form av ett förord till programbladet till Stockholms stadsteaters uppförande av The Sound of Music (hösten 2021).

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. Howev

OBJECTIVE Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting in anti-AGE-specific autoantibodies. The association of these immune responses with macro- and microvascular complications in type 1 diabetes remains unclarified. We investigated associations between MGO-modified apolipoprotein B

A Transverse Resonance Island Bucket optics has a betatron tune close to a resonance, such that the particle motion is governed by non-linear terms in the equation of motion. This results in additional stable fixed points in transverse phase-space, which can be populated with a single RF-bunch filling pattern. Thus, these optics have the potential of providing pseudo single-bunch operation, i.e. a

A novel combination of advanced gas-chromatography and detection systems coupled to a buffer-gas cell was characterized on-line to allow gas-phase chemical studies of accelerator-produced short-lived α-decaying mercury, francium, and astatine isotopes. These were produced in 40Ar- and 48Ca-induced nuclear fusion–evaporation reactions, subsequently isolated in the recoil separators MARS at Texas A&

Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of disease and no available disease-modifying treatments. Symptomatic early-stage OA of the knee (the focus of this Review) urgently needs to be identified and defined, as efficient early-stage case finding and diagnosis in primary care would enable health-care providers to proactively and substantially reduce

This paper analyzes the effect of being exposed to forced migration during childhood (ages 0-5) on educational achievement at age 15 (grade 9). Using register data from the Swedish Interdisciplinary Panel, I identify children who migrated to Sweden as a consequence of the rising conflict during the disintegration of the former Yugoslavia, and follow them until age 15, when they received their grades

The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)

Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,