Context: Test driven development (TDD) has been extensively researched and compared to traditional approaches (test last development, TLD). Existing literature reviews show varying results for TDD. Objective: This study investigates how the conclusions of existing literature reviews change when taking two study quality dimension into account, namely rigor and relevance. Method: In this study a sys

To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from

Xenon atoms are double-ionized by sequential two-photon absorption by ultrashort extreme ultraviolet free-electron laser pulses with a photon energy of 23.0 and 24.3 eV, produced by the SPring-8 Compact SASE Source test accelerator. The angular distributions of photoelectrons generated by two-photon double ionization are obtained using velocity map imaging. The results are reproduced reasonably we

Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive aldehydes, including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modif

Förintelsens röfda nejlika behandlar framför allt Raoul Wallenbergs verkningshistoria, det vill säga hur han har diskuterats och representerats efter hans försvinnande 1945. En aspekt är det politiska och diplomatiska spelet kring honom, i Sverige, USA och Ungern. En annan är framställningen av honom i monument, på film och i tv-serier. Dessutom analyseras sambanden mellan det hemliga, diplomatisk

This article explains how infrastructures with a sustainability record may evolve over time into a lock-in that slows the emergence of more sustainable urban infrastructures. A study of waste incineration in the Goteborg Metropolitan Area, Sweden, serves as an illustrative case. Taking leads from Unruh (2000, 2002), four rationales of lock-in are identified in the case: institutional, technical, c

A concept for time-sensitive optical detectors is described that shows how to confirm whether the detection device is operating in the linear response regime. By evaluating the recorded time decay of a thermographic phosphor, even weak saturation effects far from obvious situations can be identified and further related to either optical or electrical saturation. The concept has been validated by r

It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. In this thesis I have investigated

Objective Systemic sclerosis (SSc) is associated with a significant reduction in life expectancy. A simple prognostic model to predict 5-year survival in SSc was developed in 1999 in 280 patients, but it has not been validated in other patients. The predictions of a prognostic model are usually less accurate in other patients, especially from other centres or countries. A study was undertaken to v

The filamentous bacterium Microthrix parvicella causes severe separation and foaming problems at wastewater treatment plants (WWTPs). An effective control of the bacterium in activated sludge WWTPs can be accomplished by dosage with polyaluminium chloride (PAX-14). The purpose of this study was to investigate whether addition of PAX-14 affects surface properties such as the hydrophobicity of the b

Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi

Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the Europea

The cross section for the production of W bosons with subsequent decay W -> tau nu(tau) is measured with the ATLAS detector at the LHC. The analysis is based on a data sample that was recorded in 2010 at a proton-proton center-of-mass energy of root s = 7 TeV and corresponds to an integrated luminosity of 34 pb(-1). The cross section is measured in a region of high detector acceptance and then ext