Popular Abstract in Swedish Diabetes är en endokrin sjukdom som också kallas sockersjuka. Den kännetecknas av förhöjda mängder socker i blodet. Halten av socker i blodet, blodsockret, styrs av hormonet insulin, som produceras av β-celler i Langerhanska öar i bukspottskörteln. När insulin frisätts stimuleras muskler, fettväv och lever till att ta upp glukos ur blodet och lagra det. På så sätt sänksType 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for casual mechanisms underlying metabolic alterations disturbing insulin secretion. In paper

This paper examines the key parameters that affect the bubble point pressure for screen channel liquid acquisition devices in cryogenic liquid oxygen at elevated pressures and temperatures typical of a high-pressure propellant tank. An in-depth analysis of the effect of varying liquid temperature, pressure, and pressurization gas type on the bubble point is presented. Testing of a 200 x 1400 and 3

BACKGROUND: The molecular biology of renal cell carcinoma (RCC) is complex and not fully understood. We have recently found that the expression of the receptor tyrosine kinase Axl in the RCC tumors independently correlates with survival of the patients. PRINCIPAL FINDINGS: Here, we have investigated the role of Axl and its ligand Gas6, the vitamin-K dependent protein product of the growth arrest-s

Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits can be achieved. Subsequent studies, in particular two that followed a double-blin

Objective To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration

The analysis and design of a millimeter-wave passive balun on silicon substrate with small size and good balance is presented. The reason for the imbalance of the balun is analyzed and a novel method using two grounded T bars beneath the coupled lines to tune the balance is proposed. The balun was fabricated in a 65 nm CMOS process, by using broadside coupled lines with small separation, the lengt

Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, w

The present paper deals with a detailed numerical investigation of the turbulent flow inside a stationary rib-/deflector-roughened cooling channel. Various downstream-shaped deflectors including sloping-board deflectors [Cases A1, A2], guide-shaped deflectors [Cases B1, B2], and drop-shaped deflectors [Cases C1, C2] and configuration parameters such as channel aspect ratio (AR=0.5, 1 and 2), and r

Popular Abstract in Swedish Akut bukspottkörtelinflammation är en sjukdom som drabbar ungefär 35 per 100 000 invånare i Sverige årligen. Förloppet innebär i flertalet fall ett komplikationsfritt tillfrisknande. Cirka 20% drabbas dock av en allvarlig form som kräver stora sjukvårdsresurser och innebär avsevärd sjuklighet, inkluderande risk för vävnadsdöd i bukspottkörteln, lokala och spridda infektAcute pancreatitis, with an annual incidence of approximately 35 per 100 000 inhabitants in Sweden, is in most cases mild and self-limiting. Severe acute pancreatitis, affecting 10-15% of the cases is, however, associated with severe complications and even death. The optimal management of acute pancreatitis includes accurate early prediction of the disease severity. The aims of this thesis were to

In the context of the relationship between signs and concepts, this paper tackles head on some of the ongoing controversies over conceptual development and change – including the claim by some that concepts are not open to revision at all – taking the position that concepts pull apart from language and that concepts can be discussed on at least four levels: that of individual agent, community, soc

Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of the DNA base cytosine by DNA methyltransferases (DNMTs) is an important epigenetic factor regulating gene

Musculoskeletal disorders (MSD) account for the majority of total morbidity cases in the working-age Swedish population. These disorders are thought to be the reason given for one-third of total certified sick leave requests. In addition to the high cost to society, MSD involve both physical and emotional suffering, pain and financial and social problems for the injured persons. The aim of this st

In this article I discuss the Nordic province of Bohuslan in the decade after it became 'Swedish' in 1658, at the stage I describe as the province's 'transitional period'. The aim of the study is to show how the traditional understanding of what happens when national borders are redrawn needs to be understood in the light of the nature of the early modern state. Records from the district court of