Studie av aggregeringstendenser hos en homolog serie peptider med NMR-spektroskopi Examensarbetet utvärderar tillämpningen av 1H NMR-spektroskopi med vattenundertryckning vid en första undersökning av aggregeringsbeteende hos fyra närbesläktade läkemedelsmolekyler. Utveckling av peptidläkemedel står inför många svårigheter. För det första är de är relativt nya på marknaden. LäkemedelsutvecklareThe aggregation propensity of four GnRH analogues, namely D-Phe6-GnRH, ozarelix, cetrorelix and degarelix has been studied with 1H NMR spectroscopy in 100 % H2O, while tracking changes in pH. A method was developed to study aggregation propensities by variations in absolute integral values over time and with concentration. The method provided an intuitive visual comparison of the aggregation prope

Innovation plays an increasingly important role in many sectors, and receives growing interest from companies, researchers and nations. Increasing attention has been paid to the Front-End of Innovation (FEI), the initial part of the innovation process, where prociency has been shown to have the greatest impact on future innovation success. Research is however centered around product innovation in

This Master Thesis describes the product development process of creating a product with the aim of preventing and removing spiders obstructing the image of surveillance cameras. The project was conducted on behalf of Axis Communications AB, which is a market leading company in network cam- eras. The thesis consist of two main parts. The first part contains a background study of the problem, an inv

Det finns flertal fall då grafdatabaser överträffar traditionella relationsdatabasers pre-standa. Är grafdatabaser potentiellt den nya lagringsmetoden vid stor mängd sam-mankopplad data? Vilka villkor krävs? För att sätta det på prov har vi skapat entestmiljö med en stor mängd relationsbunden data.In an age of increasing usage of heavily interconnected platforms, graph databases have increased in popularity due to their ease of modelling these systems. This thesis will evaluate if the graph database Neo4j can be used to model Lime's CRM System efficiently by comparing the performance of Neo4j and MS SQL on queries similar to those existing in Lime CRM. To benchmark the databases, they w

Syftet med den här studien var att undersöka om det finns några skillnader i psykologiskt välbefinnande mellan studenter med låg- respektive hög grad av Fear of Missing out (FoMo). Trots att tidigare forskning visar att FoMo är vanligt förekommande och ofta associerat med ohälsa, är fenomenet relativt outforskat inom det psykologiska forskningsfältet. För att undersöka relationen mellan FoMo och pThe purpose of this study was to examine whether there are any differences in psychological well-being between students with low- respectively high levels of Fear of Missing out (FoMo). Although previous research shows that FoMo is commonly occurring and often associated with illness, the phenomenon is relatively unexplored in the field of psychological research. To investigate the relationship be

Vad innebär det att spela en transkription? Är transkriptionen relevant? Vilka är skillnaderna och likheterna mellan olika transkriptioner? I syfte att fördjupa mig i transkriptioner inom klassisk musik, valde jag att utgå från Schuberts arpeggionesonat. Ett stycke som transkriberats många gånger för många olika instrument och som, från början, är skrivet för ett instrument som hade en kort tid a

I denna examensarbetesrapport beskrivs utvecklingen av en dold och hållbar produkt för ström och signalöverföring till skjutdörrars rörliga dörrblad. Examensarbetet har genomförts i samarbete med Assa Abloy Entrance Systems, med målet att möjliggöra användningen av tillbehör som smarta glas, skärmar integrerade i dörrglaset, elektriska lås och sensorer monterade på dörrbladen hos deras skjutdörrarThis master’s thesis report describes the product development process of a durable and concealed product for transferring power and signals to the moving door leafs of sliding doors. The thesis has been conducted in collaboration with Assa Abloy Entrance Systems, with the goal of enabling the use of accessories such as privacy e-glass, screens integrated in the glass, electric locks and sensors mo

Purpose: The purpose of this study is to investigate how the current green bond standards influence the use of proceeds obtained from the issuance of green bonds. We also aim to explore the limitations of the standards and how the standards can be further improved to promote the development of the green bond market. Methodology: A qualitative research approach was used, consisting of a literature

This study investigated how younger and older men differ in their coping behaviour and set out to explore the relationship with changing masculinity standards. In order to investigate this theme, a combined quantitative and qualitative method with convenience sampling was used. The survey, Brief COPE, was employed to measure differences in coping behavior over two generations (Younger = 30, Older

In May of 2017, the city council of Malmö decided to establish a new contact center. This contact center replaced the original call center with the expectation to increase democracy, accessibility, and more efficient service. As a part of the transition, the previous telephonist workers were terminated and replaced by the new profession kommunvägledare. This study reaches from the feminist discuss

Sveriges elsystem står inför en rad kommande utmaningar. En lovande lösning till många av dessa är efterfrågeflexibilitet. Men vad är byggnaders möjligheter och begränsningar att vara flexibla i sin elanvändning? Förutsättningarna för elförsörjningen i Sverige förändras i takt med att kärnkraften gradvis fasas ut och ersätts med väderberoende elproduktion i form av vind- och solkraft. Detta sker Sweden is heading towards an energy system with less nuclear power and more intermittent energy sources. Together with the coming electrification of the transport and industry sector, this challenges the future stability of the Swedish power system. However, a part of the solution could be that consumption of electricity temporarily is adjusted to facilitate the operation of the power system, reco

This thesis studies segmentation and categorization of highway road data, with the ambition that the understanding gained could be used for virtual verification of road scenarios for self-driving systems. We will look at a few approaches for segmentation of the road data, such as heuristics as well as methods involving optimization. The result of the segmentation is categorized and we then explore

The world is currently facing many great challenges, including a rising inequality as a result of the benefits occurring from economic development accrues to some individuals on the expense of others. This is an issue which is even more significant in the Global South. Hence, social innovations have been proposed as an important factor to tackle this problem. Yet, many social innovations fail not

This master thesis was produced with the intention of being a conceptual study of existing solutions and development of new solutions for a train mounted system for collection of brake dust particles from trains. Furthermore, an investigation of the risks attributable to brake dust and why the reduction of it is necessary was made. The problem was approached systematically through the adoption of

The current global scenario is such where impact on the environment is becoming a rising concern. Global automotive manufacturers have focused more towards hybrid and electric vehicles as both more aware customers and governmental legislation have begun demanding higher emission standards. One of the many ways that Volvo Car Group approaches this trend is by mild hybridization which is by assistin

Many regions around the world suffer from occasional or permanent droughts. Recent years have shown that although Sweden is not a water scarce country, it is vulnerable to dry peri- ods. As drinking water is applied in not only households, but within agriculture and indus- tries, this thesis explores the opportunities to achieve an improved management of water re- sources, by investigating the pos

The present study aimed at investigating the recent phenomenon termed Fear of missing out (FOMO), which builds on a feeling of constantly having to be connected to what other people are doing on social media in order to not miss out. The purpose of this study was to see if a link between FOMO and social media addiction is present and if Swedish university students’ well-being and academic performa

A prototype invasive (quasi-parasitic) thermal-neutron beam monitor based on isotropic neutron scattering from a thin natural Vanadium foil and standard $^3$He proportional counters has been conceptualized, designed, simulated, calibrated, and commissioned. As the beam monitor is invasive, very low neutron-beam attenuation is a necessary characteristic. Further, response linearity over as wide a r

The development of today’s energy-efficient dwellings often results in highly technical building solutions. We try to shield ourselves and our buildings as much as we can from the outdoors and subsequently loose an essential connection to the elements. Traditional design principals fall into oblivion and high-rise glass towers are justified with technological progress. By implementing selective st

Proteinupprening är ett viktigt och grundläggande steg för att kunna använda proteiner som läkemedel. Att utveckla en effektiv uppreningsprocess är viktigt utifrån såväl ett tidsperspektiv; som kostnads- och miljöperspektiv och målet med processen är att få ut så mycket rent protein som möjligt, utan att proteinets aktivitet reduceras. I det här projektet har en uppreningsprocess för proteas-X utvThe epidermal growth factor receptor (EGFR) is a receptor involved in cell proliferation. It is frequently overregulated in cancer cells, making it an attractive target for cancer therapeutics. One possible pharmaceutical is protease-X; a protein involved in the cleavage of the EGFR and thus, a way to regulate the receptor’s activity and lead the cancer cells to apoptosis. The aim of this thesis h