Parkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of alpha-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are neuroprotective or pathological remains controversial, because prefibrillar oligomers may be more toxic than amyloid inclusions. Thus, whether therapies should target inclusions, preamyloid oligo

OBJECTIVE-To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS-GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or control subjects from Finland. Altogether, 289 (5.9%) were GADA(+)-a total of 253 GADA(+) and 2,511 GADA(-) subjects participate

The flow around a complete model wind turbine is computed using LES and the immersed boundary method. The influence of inlet velocity profile and turbulence level is evaluated. The inlet velocity profile was found to have major influence in the upper regions of the flow field. The imposed turbulence level had no major influence on the turbulent spectra but it's effect is clearly seen on the genera

Insolubilized humic acid (IHA) was prepared in the laboratory by heating approach. Through the comparison between the endothermic peaks, optimal heating temperature was determined to be 330A degrees C. The modified IHA then was characterized by TG-DTA, SEM, FTIR, element analysis, and nitrogen adsorption-desorption isotherms. The removal efficiency of p-nitrophenol from the aqueous solution by ads

A 37-year-old female subject had been convicted of driving under the influence of alcohol, and 19 months later, claimed abstinence after supervised disulfiram treatment. Our aim was to elucidate the value of direct ethanol metabolites as measures of abstinence. Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE) in hair, phosphatidylethanol in whole blood and EtG and ethyl sulphate in urine

Bryophytes have until now been absent from all hypotheses regarding the origin of insect pollination of seed plants. The discovery that both springtails and mites are able to transfer sperm in mosses makes it possible to suggest a ’Bryophyte precursor hypothesis of plant pollination’ stating that animal-mediated fertilization in mosses and insect pollination in seed plants is historically linked b

Anuran sex ratio at breeding sites is typically male biased. Such sex ratios may be due to poor female survival, to females not breeding as frequently as males and/or to males becoming sexually mature earlier than females. In the present study, the first two factors are analyzed in a common toad (Bufo bufo) population in southern Sweden. Toads were captured, marked and recaptured at the breeding s

Cadmium is a non-essential toxic metal with multiple adverse health effects. Cadmium has been shown to be associated with cardiovascular diseases, but few studies have investigated heart failure (HF) and none of them reported atrial fibrillation (AF). We examined whether cadmium exposure is associated with incidence of HF or AF.

Abstract in UndeterminedIt has long been known that a major larger foraminifera turnover (LFT) occurred at the boundary between the Thanetian and Ilerdian stages, but its possible correlation with the Paleocene-Eocene thermal maximum (PETM) was unsuspected until the work of Baceta (1996), and has been controversial ever since. After summarizing the history of this controversy, we present informati

Danish version of study of press reception of 1864.

The choice and implementation of pricing strategy is often described as an optimization problem where the firm chooses the most profitable pricing strategy given certain external determinants. Contrary to this notion, recent research indicates that the pricing of products is a costly and complex activity, and that firms may differ in their capability to implement pricing strategies. This case stud

This work presents studies of the valence band of two Kondo lattice systems: Ce2Co0.8Si3.2, which is paramagnetic with the Kondo temperature T-K approximate to 50 K and Ce2RhSi3, which is antiferromagnetic below T-N = 4.5 K and exhibits TK approximate to 9 K. The photoemission spectra, which are obtained with photon energy tuned to Ce - 4d 4f resonance, reveal a Kondo peak at the Fermi energy (E-F

Weathering of soil minerals is important for the recovery from acidification and for the sustainability of forestry. However, there is still substantial uncertainty about its absolute rate. This study presents a harmonized comparison of field weathering rates estimated with the mechanistic model PROFILE and the depletion method for 16 intensively sampled soil profiles across Sweden representing di

A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to be explained by heritable factors. Recent genome-wide association studies (GWAS) have successfully identified a number of common SNPs associated with TGCT. It is however, unclear how much common variation there is left to be accounted for by other, yet to be identified, common SNPs and what contribution common genetic var

Papillon-Lefevre syndrome (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial defense. Despite serine protease-deficient immune cell populations, PLS patients do not exhibit marked immunodeficiency. Here, we characterized a 24-year-old woman who had suffered from severe juvenile peri

Climate change poses a serious threat to sustainable urban development, placing many cities at risk. As a consequence, city authorities are increasingly facing the challenge of finding ways to include adaptation strategies into their work, although related knowledge and competence is still scarce and fragmented. With the aim to contribute to knowledge development and organizational learning, the o

Popular Abstract in English During recent decades, significant changes in fertility pattern are seen in the Western World. Declining birth rates and smaller family sizes affect the population size, but also cause unwanted effects for the desired number of children to be achieved by the individual couple. Also involuntary childlessness is a consequence of postponing childbearing to an age where theDeclining birthrates and infertility are now a common problem in the Western World. Due to the tendency to postpone childbearing an increasing age of women who consider motherhood is generally seen. A factor closely related to female fertility is the ovarian reserve, a term used to designate both quantitative as well as qualitative aspects of the remaining gametes in the female gonads. Despite a n

Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inh