Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although the involvement of Gal-3 in tumour progression, resistance to treatment and immunosuppression has long been studied in different cancer types, mainly outside the central nervous system, its elevated expression in myeloid

The first example of a material capable of spatiotemporal catch and release of singlet oxygen (1O2) in gel phase is presented. Several low molecular weight organogelators based around an oxotriphenylhexanoate (OTHO) core are developed and optimized with regard to; their gelation properties, and ability of releasing 1O2 upon thermal and/or photochemical external stimuli, in both gel phase and solut

The concentration of colored dissolved organic matter (CDOM) in lakes is strongly influenced by climate, land cover, and topographic settings, but it is not known how drought may affect the relative importance of these controls. Here, we evaluate the controls of CDOM during two summers with strongly contrasting values of the Palmer drought index (PDI), indicating wet vs. dry conditions. We hypothe

Representations of the slim body have traditionally been at the centre of scholarly interest in dieting culture, whereas food often remains a shadowy presence compared with more persistent themes of body discipline, slenderness and anti-fat messages. This article offers a different perspective on weight-loss dieting, placing food at the very centre of the analysis. By examining different diets in

Background: There has been a notable decrease in antibiotic prescribing in the last thirty years in Sweden. Little is known about factors influencing antibiotic prescribing over several years. Objective: To compare primary care physicians who, over time, reduced their antibiotic prescribing for respiratory tract infections with those who remained either high or low prescribers regarding potentiall

The standard cosmological model, the ΓCDM model, is the most suitable description for our universe. This framework can explain the accelerated expansion phase of the universe but still is not immune to open problems when it comes to the comparison with observations. One of the most critical issues is the so-called Hubble constant (H0) tension, namely, the difference of about 5σ as an average betwe

Impactful applications such as materials discovery, hardware design, neural architecture search, or portfolio optimization require optimizing high-dimensional black-box functions with mixed and combinatorial input spaces. While Bayesian optimization has recently made significant progress in solving such problems, an in-depth analysis reveals that the current state-of-the-art methods are not reliab

Many diatoms form long chains and the distribution of chain lengths within a species depends on several environmental factors, among them grazing risk. Larger grazers, such as copepods, efficiently handle and ingest even very long chains but are less efficient with individual cells, whereas most smaller grazers are unable to feed on chains exceeding a few cells in length. Copepod cues make several

Scheduling between mates in species with long-term pair bonds can be essential for positive fitness. The annual cycle in photoperiod is the primary environmental cue used by many animals to synchronize behavior and physiology among members of a population, and animals that migrate must have similar annual schedules to ensure successful breeding. However, we know little about whether members of mat

IntroductionOccupational balance has been investigated in different populations but less in stroke survivors. Previous studies have focussed on occupational balance among stroke survivors of working age (15–64 years of age), showing they did not perceive they had occupational balance. There is, therefore, a lack of knowledge of how older stroke survivors perceive their occupational balance. The aiIntroductionOccupational balance has been investigated in different populations but less in stroke survivors. Previous studies have focussed on occupational balance among stroke survivors of working age (15–64 years of age), showing they did not perceive they had occupational balance. There is, therefore, a lack of knowledge of how older stroke survivors perceive their occupational balance. The ai

The present study collected a wide range of experimental data samples, including 855 records from various types of cylindrical weirs under diverse hydraulic conditions, setting the stage for an in-depth analysis for modeling of discharge coefficient. For this purpose, the prediction capability of four kernel-based methods (SVM, GPR, KELM, and KRR) and four neural network-based methods (FFBP, CFBP,

The Storage Location Assignment Problem (SLAP) is of central importance in warehouse operations. An important research challenge lies in generalizing the SLAP such that it is not tied to certain order-picking methodologies, constraints, or warehouse layouts. We propose the OBP-based SLAP, where the quality of a location assignment is obtained by optimizing an Order Batching Problem (OBP). For the

Background: Blood typing is essential for safe transfusions and is performed serologically or genetically. Genotyping predominantly focuses on coding regions, but non-coding variants may affect gene regulation, as demonstrated in the ABO, FY and XG systems. To uncover regulatory loci, we expanded a recently developed bioinformatics pipeline for discovery of non-coding variants by including additio

The implementation of deep learning algorithms has brought new perspectives to plankton ecology. Emerging as an alternative approach to established methods, deep learning offers objective schemes to investigate plankton organisms in diverse environments. We provide an overview of deep-learning-based methods including detection and classification of phytoplankton and zooplankton images, foraging an

This article looks at the photographic parts of the archive of racial biology in Uppsala, Sweden. This material is approached both through works by Swedish Sámi artist Katarina Pirak Sikku as well as through close engagements with the archive itself and its historical circumstances. In the article, the focus is on affective and emotional relations to the archival photographs and the events of thei

Background: Heart failure (HF) has a high prevalence in an elderly population and leads to a substantial hospitalization and mortality. The objective of this study was to investigate factors that affect hospitalization and mortality in an elderly population. Methods: A retrospective observational study was conducted of HF patients aged 76–95 years residing in Region Halland, Sweden. Between 2013 a

Background: Cognitive impairment is common in Parkinson’s disease (PD), but care needs and resource use for those with significant cognitive impairment are not well established. Methods: 675 participants with PD from the international Care of Late-Stage Parkinsonism (CLaSP) study were grouped into those without (n = 333, 49%) and with cognitive impairment (MMSE < 24/30 or diagnosis of dementia or

Older adults have multiple medical and social care needs, requiring a shift toward an integrated person-centered model of care. Our objective was to describe and summarize Swedish experiences of integrated person-centered care by reviewing studies published between 2000 and 2023, and to identify the main challenges and scientific gaps through expert discussions. Seventy-three publications were ide

There are substantial concerns about impaired honey bee health and colony losses due to several poorly understood factors. We used MALDI profiling (MALDI BeeTyping®) analysis to investigate how some environmental and management factors under field conditions across Europe affected the honey bee haemolymph peptidome (all peptides in the circulatory fluid), as a profile of molecular markers represen