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Introduction: Opioid maintenance treatment is the dominant treatment for treating opioid dependence. The treatment is individualised and combines pharmaceuticals with psychosocial support. Aim: This study aimed to increase the understanding of the pathway to recovery, by illustrating the life course of patients within OMT before and after starting treatment using time-geographic life charts. Metho
Objective: Children born extremely preterm (EPT) vary greatly regarding academic outcomes, underscoring the need to investigate subgroups in large representative samples. This study aimed to (1) examine academic outcomes in EPT children versus full-term controls and (2) examine the role of maternal education, child sex, maternal origin, cognitive ability and the presence of attention deficit hyper
ObjectiveFoetal-neonatal alloimmune thrombocytopaenia (FNAIT) is a rare disease, most commonly caused by maternal alloantibodies to human platelet antigen (HPA)-1a that can result in severe bleeding. The present study was designed to determine the frequency of higher risk for HPA-1a alloimmunisation and development of FNAIT among a racially and ethnically diverse cohort of pregnant women.DesignLon
Purpose: To explore how the Every Day Throughout Life (EDTL) model supports primary care transformation by enabling residents, families, staff, and volunteers to navigate socialparticipation, joy, and engagement in nursing homes, thereby enhancing wellbeing and quality oflife.Context: Norwegian nursing homes are integral to municipal primary care systems, providinground-the-clock services for peop
Although cross-sector collaborations drive innovation, organizational policies as legitimation signals attracting such collaborations remain unexplored. This study examines the mediating role of environmental partnerships between organizational policies and environmental innovation. Using panel data (2014–2024) comprising 3372 firm-year observations from 454 consumer sector firms across 45 countri
Importance Cold knife conization (CKC) and the loop electrosurgical excision procedure (LEEP) are standard treatments for cervical intraepithelial neoplasia and carcinoma in situ. However, the comparative long-term effectiveness of these procedures in promoting human papillomavirus (HPV) clearance and preventing recurrent cervical lesions remains uncertain. Objective To compare the long-term incid
Self-supervised pre-training based on next-token prediction has enabled large language models to capture the underlying structure of text, and has led to unprecedented performance on a large array of tasks when applied at scale. Similarly, autonomous driving generates vast amounts of spatiotemporal data, alluding to the possibility of harnessing scale to learn the underlying geometric and semantic
Elevated atmospheric CO2 concentration (eCO2) is expected to substantially exacerbate Compound Drought and Heatwave (CDHW) events, posing increasing risks to ecosystems and human society. However, the role of land-atmosphere interactions in regulating CDHW events under eCO2 remains poorly understood. Here we investigated the contribution of land-atmosphere interactions to the global intensificatio
Telomere length (TL) has been proposed as a marker of appendicular lean mass (ALM) decline; however, longitudinal evidence remains limited. We aimed to investigate the longitudinal association between TL and 6-year trajectories of ALM. This longitudinal study included 185 older adults aged 55–75 years with overweight or obesity and metabolic syndrome at baseline. Baseline TL was assessed using a m
This essay examines how R. A. Markus and Erik Peterson conceptualize law and political authority. Both Catholic converts reject the Aristotelian view of the human being as fundamentally a political animal. Instead, they articulate an eschatological anthropology in which law and politics emerge from the Fall: necessary under present conditions yet ultimately ordered toward redemption. Markus, drawi
I den här studien utvärderar vi geologiska arkiv och ett flertal geologiska metoder för att identifiera och datera historiska stormflodshändelser längs Hallands kust. Vi har också undersökt en lokal vid Löderup i Skåne som påverkats av en modern stormflod under stormen Babet hösten 2023. Genom fjärranalysbaserat platsurval, fältarbete samt olika laboratorieanalyser inklusive dateringsmetoder testaThis study evaluates geological archives and a suite of proxy methods to identify and date past storm-surge events along the Halland coast, southwest Sweden, with a modern analogue site at Löderup in Scania. Using GIS-based site selection, targeted fieldwork and laboratory analyses including dating methods, we tested which coastal settings and methods best record overwash deposits and whether the
Gastrointestinal (GI) cancers represent a significant global health burden, characterized by high incidence, poor prognosis, and limited response to monotherapies. The advent of bispecific antibodies (BsAbs) has introduced a novel therapeutic paradigm, enabling dual targeting of tumor-associated antigens and immune effectors to enhance antitumor immunity. This review provides a comprehensive overv
The estimation of the number of defective tendons in post-tensioned concrete bridges is a key input for the reliability assessment of prestressed girders. However, special inspection methods for detecting voids and assessing tendon condition are intrusive, time-consuming, and costly, and the quantitative definition of an inspection sample size that meaningfully reduces epistemic uncertainty while
