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Severity assessment of patients with haemophilia A (HA) is traditionally based on FVIII activity (FVIII:C). Clinical phenotype of HA patients often differs between individuals with the same FVIII:C determined with clotting and chromogenic assays. The aim of this study was to assess the influence of the FVIII:C on thrombin generation (TG) assay parameters both in vitro and ex-vivo postinfusion plas
Antibody-based microarray is a novel technology with great promise in biomedicine that will provide unique means to perform global proteome analysis. In the process of designing the high-density antibody microarrays required, several critical key issues have been identified that remain to be resolved. In particular, there is a great need for specific and selective approaches enabling non-purified
Biological processes exhibit different behavior depending on the influent loads, temperature, microorganism activity, and soon. It has been shown that a combination of several models can provide a suitable approach to model such processes. In the present study, we developed a multiple statistical model approach for the monitoring of biological batch processes. The proposed method consists of four
Background: Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular overthe- counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate. We have previously shown that acetaminophen is further metabolized to N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) by fa
Ever since the term ‘gentrification’ was coined by Ruth Glass in 1964 this specific form of socio-economic change has attracted much attention within the social sciences, not least from geographers and sociologists. This has generated a rich discussion on the mechanisms behind the process and, to a lesser extent, a debate on positive and negative outcomes of gentrification. Critical voices have de
Context Agile software development has become popular in the past decade without being sufficiently defined. The Agile principles can be instantiated differently which creates different perceptions of Agility. This has resulted in several frameworks being presented in the research literature to evaluate the level of Agility. However, the evidence of their actual use in practice is limited. Objec
Gene expression analyses were performed on 121 consecutive childhood leukemias (87 B-lineage acute lymphoblastic leukemias (ALLs), 11 T-cell ALLs and 23 acute myeloid leukemias (AMLs)), investigated during an 8-year period at a single center. The supervised learning algorithm k-nearest neighbor was utilized to build gene expression predictors that could classify the ALLs/AMLs according to clinical
Lipids have been implicated in ß-cell stimulus-secretion coupling. Thus, lipases in ß-cells would be required to generate coupling factors from intracellular lipids. Indeed, we found that glucose stimulates lipolysis in rodent islets and clonal ß-cells. Lipolysis and diglyceride lipase activity in islets are abolished by orlistat, a pan-lipase inhibitor. Moreover, orlistat dose-dependently inhibit
On 7 December 1975 Indonesian troops invaded the former Portuguese colony of East Timor, which had unilaterally declared itself independent on 28 November the same year. The immediate background to the Indonesian invasion of East Timor was that the old regime in Portugal was overthrown in April 1974, resulting in a decolonisation programme for Portugal's colonies. Immediately after the invasion In
In the past decade, the literature on transitions toward sustainable socio-technical systems has made a considerable contribution in understanding the complex and multi-dimensional shifts considered necessary to adapt societies and economies to sustainable modes of production and consumption. However, transition analyses have often neglected where transitions take place, and the spatial configurat
Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet
In this study, the growth of a short edge crack during more than 14 000 cycles of fatigue loading is investigated in detail. An edge crack, in a semi-infinite body with no pre-existing obstacles present, is modelled in a boundary element approach by a distribution of dislocation dipoles. The fatigue cycles are fully reversed (R = -1), and the load range is well below the threshold for long fatigue
Background: Tumour necrosis factor-alpha (TNF-alpha) is a pleiotropic pro-inflammatory cytokine, which is rapidly upregulated in the brain after injury. TNF-alpha acts by binding to its receptors, TNF-R1 (p55) and TNF-R2 (p75), on the cell surface. The aim of this study was first to investigate if there is altered expression of TNF-alpha and TNF-alpha receptors in cerebral artery walls following g
Popular Abstract in Swedish I Sverige finns cirka 350 000 personer med diabetes. Motsvarande siffra i hela världen är cirka 350 miljoner människor och forskning talar för att antalet personer med diabetes kommer att öka dramatiskt under de närmsta decennierna. Den största ökningen sker i utvecklingsländer i urbana områden, till stor del beroende på livsstilsförändringar och förändringar i diet. UtSpecific aims: To examine whether the sociodemographic characteristics of patients with type 2 diabetes affect the odds of reaching the recommended treatment goals for HbA1c and blood lipids (study 1). To investigate whether the odds of coronary heart disease are higher in patients with diabetes living in deprived neighborhoods than in those living in wealthy neighborhoods (Study 2). To examine th
1 alpha,25-Dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D-3 (25(OH)D-3) and 24R,25-dihydroxyvitamin D-3 (24R,25(OH)(2)D-3) broadened the vitamin D-3 endocrine system, however, the current data are fragmented and a systematic understanding is lacking. Here we performed the first systematic study o
The Sheinwoodian succession of Gotland comprises the Högklint, Tofta and Hangvar Formations and most of the Slite Group. The succession consists of hierarchically ordered shallow marine depositional cycles, produced by orbitally forced climate changes. During warmer and wetter intervals (climate maxima) more carbonate was produced than during the cooler and dryer climate minima. Higher carbonate p
Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie
In this study, we compare annual fluxes of methane (CH4), nitrous oxide (N2O) and soil respiratory carbon dioxide (CO2) measured at nine European peatlands (n = 4) and shrublands (n = 5). The sites range from northern Sweden to Spain, covering a span in mean annual air temperature from 0 to 16 degrees C, and in annual precipitation from 300 to 1300 mm yr(-1). The effects of climate change, includi
