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Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av

Conservation genomics is a rapidly growing subdiscipline of conservation biology that uses genome-wide information to inform management of biodiversity at all levels. Such efforts typically focus on species or systems of conservation interest, but rarely consider associated microbes. At least three major approaches have been used to study how microorganisms broadly contribute to conservation areas

Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t

Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i

Interconnected societal challenges such as climate change, biodiversity loss and food security demand immediate and coordinated action across local to global scales, guided by coherent policies and management mechanisms. Reflecting on the critical need to address societal challenges, Nature-based Solutions in marine and coastal environments, known as blue NBS, have emerged as an important part of

Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d

Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities

Hydrogen energy technologies are forecasted to play a critical supporting role in global decarbonisation efforts, as reflected by the growth of national hydrogen energy strategies in recent years. Notably, the UK government published its Hydrogen Strategy in August 2021 to support decarbonisation targets and energy security ambitions. While establishing techno-economic feasibility for hydrogen ene

Decarbonising the global housing stock is imperative for reaching climate change targets. In the United Kingdom, hydrogen is currently being tested as a replacement fuel for natural gas, which could be used to supply low-carbon energy to parts of the country. Transitioning the residential sector towards a net-zero future will call for an inclusive understanding of consumer preferences for emerging

In an era characterised by political instability, economic uncertainty and mounting environmental pressures, hydrogen fuel is being positioned as a critical piece of the global energy security and clean energy agenda. The policy push is noteworthy in the United Kingdom, where the government is targeting industrial decarbonisation via hydrogen, while exploring a potential role for hydrogen-fuelled

During the last decade the intersection between social welfare research and the ecological crisishas been gaining increasing interest through discussions about sustainable welfare and eco-social policies. Less attention has been paid, however, to eco-social risks and to how climatechange “will impact the nature and distribution of social risks across di!erent parts of thepopulation” (Hirvilammi et

Accelerating global demand for critical minerals intensifies pressures on Indigenous territories, exacerbating tensions between extractive imperatives and Indigenous land rights. This thesis critically analyses how state-mediated institutional arrangements in Sweden and Colombia shape Indigenous peoples' participation, authority, and influence in land-use decision-making related to critical mi

Can institutional expansion be interpreted as a form of state control or surveillance?Globalization and the digital era have enabled criminals to commit financial crimes and financing terrorism by moving money across borders, making it more difficult for national authorities to detect and prevent such crimes. In response to raised financial crimes, institutions have expanded their mandate and impl

Drug use is governed today by a global prohibition regime that medicalizes and criminalizes people who use drugs, producing marginalization, risk environments, and illicit markets. In parallel, digital platformization has enabled darknet cryptomarkets to reorganize drug distribution and create new social contexts in which drugs, markets, and users are discursively constructed. This thesis examines

The European Union has long been regarded as a global transformative power, capable of promoting democratic reforms in candidate countries through its merit-based enlargement process. However, democratic backsliding in the Western Balkans has raised concerns about the credibility and effectiveness of EU conditionality. This thesis examines the extent to which the EU enlargement process has enabled

The construction industry faces many challenges, among which sustainability has become a prominent global goal to assess. In a European context, environmental certifications such as the Nordic Swan Ecolabel are a key incentive for addressing sustainability challenges and aim to reach the 2030 goals (UNFCCC, 2015). However, these incentives and considerations must be integrated with the requirement

Global manufacturing companies operate in increasingly uncertain and complex environments where changes in sourcing strategies, supplier structures and logistics networks create significant challenges for decisionmaking. Traditional analytical methods often struggle to capture the dynamic and interconnected nature of modern supply chains, limiting their ability to support proactive evaluation of s

The effectiveness of early warning systems (EWS) is frequently emphasised as being dependent on the integration of vulnerability, yet such considerations are often argued as lacking in practice by international organisations and scientific communities. Although this is acknowledged by global initiatives, less attention has been given to understanding vulnerability integration from the perspectives