Filetype
Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting in a Val-Met replacement in the C-type lectin domain of aggrecan. To understand the cellular pathogenesis of this c
In a global competitive economic environment, resources that are scarce or irreplicable are a source of sustained competitive advantage for companies and organizations. Knowledge-based resources are a major and increasing driver of long term competitive advantage. Most accounting standards however do not allow for knowledge-based resource calculations, including the most important of these, intell
The survival of asteroid Vesta during the violent early history of the Solar System is a pivotal constraint on theories of planetary formation. Particularly important from this perspective is the amount of olivine excavated from the vestan mantle by impacts, as this constrains both the interior structure of Vesta and the number of major impacts the asteroid suffered during its life. The NASA Dawn
The use of very large instrumentation, usually called Big Science, became an important part of Western science systems after World War II, with nuclear and particle physics at the center. Throughout the Cold War era, however, science policy priorities and objectives gradually shifted and in parallel therewith, new uses of Big Science emerged that were oriented to the study of materials and later a
A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the onl
The generation of human induced neurons (hiNs) via exogenous delivery of neural transcription factors represents a novel technique to obtain disease and patient specific neurons. These cells have the potential to be used for disease modeling, diagnostics and drug screening, and also to be further developed for brain repair. In the present study, we utilized hiNs to develop an unbiased screening as
Some foreign policy analysts believe that what we are witnessing in the 21st century is nothing short of a reconfiguring of the global political order - with China firmly positioned at the helm as a (re)emerging great power. At present, the notion of the imminent establishment of a ‘new world order with Chinese characteristics’ is increasingly gaining traction. This sentiment has long permeated fo
BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood.METHODS: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measu
Chronic Obstructive Pulmonary Disease (COPD) is a common disease that in its advanced stages is a life-limiting condition and a leading cause of death globally. This thesis aims at increasing the understanding of the socioeconomic disparities that exist both for COPD and its major risk factor, tobacco smoking. A related aim is to advance the theory and epidemiological methods used to evaluate equi
Background: People with Parkinson’s disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life. There is a knowledge gap regarding predictive factors of perceived walking difficulties in people with PD. Such knowledge could be useful when designing intervention studies. This study aimed to investigate how perce
The ongoing COVID-19 pandemic has radically changed the way we live and had an enormous impact on the global healthcare system [ [1]]. Among many restrictions imposed on the societies, the national lockdowns have particularly disrupted the natural social networks and forced citizens to involuntary isolation. As a result, many patients have felt discouraged to visit their doctors, while emergency d
Background: We report the effects of the presentation of an idiopathic subdural hematoma (SDH) in an adult domestic pig on the glymphatic system, a brain-wide solute clearance system. This accidental finding is based on our recently published study that described this system for the first time in large mammals. Our current results define the need to investigate cerebrovascular pathologies that cou
Antimicrobial resistance (AMR) threatens global public health and modern surgical medicine. Expression of β-lactamase genes is the major mechanism by which pathogens become antibiotic resistant. Pathogens expressing extended spectrum β-lactamases (ESBL) and carbapenemases (CP) are especially difficult to treat and are associated with increased hospitalization and mortality rates. Despite considera
Germany has one of the most ambitious climate policy goals worldwide, having pledged to reduce national emissions by 40% by 2020, and 80–95% by 2050 (base year: 1990). 2015 data suggests that progress on decarbonisation has slowed, also because emissions from the transport sector have grown. Road transport, which is contributing 20.5% to Germany's CO2 emissions, has become a major obstacle to achi
The pathogenesis of cerebral ischaemia after subarachnoid haemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether specific protein kinas C (PKC) inhibition in rats could alter the transcriptional SAH induced Endothelin (ET) type B and 5-hydroxytryptamine type 1B (5-HT1B) receptor upregulation and prevent the associated cerebral blood flow (CBF) reduction. T
Lifelong Learning (LLL) involves the formal and informal education and learning of individuals and by extension society in a bid to function efficiently in today’s knowledge world. This Learning is not limited by age, race, or other susceptible circumstances; it is instead encouraged and seen in the contexts of adult learning, continuing learning, and work/ professional learning. By de-facto, it i
Trauma is a highly topical subject of growing relevance in different contexts and scientific traditions that deal with societal challenges and transformation. At the same time, knowledge on different understandings of trauma is still scarce and scattered across disciplines. Against this background, we present and discuss the complexity of trauma understandings from five selected disciplinary persp
Background: The continuous global rise of end-stage kidney disease creates a growing demand of economically beneficial home-based kidney replacement therapies such as peritoneal dialysis (PD). However, undesirable absorption and exposure of peritoneal tissues to glucose remain major limitations of PD. Methods: We compared a reference (standard) automated PD regimen 6 × 2 L 1.36% glucose (76 mmol/L
