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BACKGROUND AND PURPOSE: Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially in children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since TBI is associated with multiple late adverse effects, recommendations may help to standardi
OBJECTIVE: To assess health-related quality of life (HRQOL) in a large multicenter cohort of children and young adults with Marfan syndrome participating in the Pediatric Heart Network Marfan Trial.STUDY DESIGN: The Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales were administered to 321 subjects with Marfan syndrome (5-25 years). PedsQL scores were compared with healthy popul
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal carcinoma. Patients with positive lymph node status have worse survival after CRS-HIPEC, which is probably due to higher rates of systemic failure. In this study, we analysed the effect of administration and timing of systemic chemot
Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not been possible since the majority of cells are non-HSCs and single cell-initiated cultures have substantial clone-to-clone variability. Using the Fgd5
Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with t
The drivers of regional parasite distributions are poorly understood, especially in comparison with those of free-living species. For vector-transmitted parasites, in particular, distributions might be influenced by host-switching and by parasite dispersal with primary hosts and vectors. We surveyed haemosporidian blood parasites (Plasmodium and Haemoproteus) of small land birds in eastern North A
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is yet to be defined. In this study, we manually curated 1235 SVs which can ultimately be used to evaluate SV callers ortrain machine learning models. We devel
BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C
BACKGROUND: Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,0
Established in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested in stakeholder engagement in research and guidelines. The MuSE group is developing guidance for stakeholder engagement in the development of health and healthcare guideline development. The development of this guidance has included multiple meetings with stakeholde
BACKGROUND: Quantifying bone mineral density (BMD) on CT using commercial software demonstrates good-to-excellent correlations with dual-energy x-ray absorptiometry (DEXA) results. However, previous techniques to measure Hounsfield units (HUs) within the proximal femur demonstrate less successful correlation with DEXA results. An effective method of measuring HUs of the proximal femur from CT colo
Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the cellular targets are poorly characterized. Here, we describe an inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3), a regulator of DNA repair and mitotic progression. In vitro profiling against 12 members of the enzyme
AIMS: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.METHODS AND RESULTS: The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited
Hållbara livsstilar och H+ En forskningsöversikt och diskussion ANETTE SVINGSTEDT OCH CHRISTIAN FUENTES SERVICE MANAGEMENT & TJÄNSTEVETENSKAP | LUNDS UNIVERSITET 1 Hållbara livsstilar och H+ En forskningsöversikt och diskussion Anette Svingstedt Christian Fuentes Ins t i tu t ionen fö r serv ice management och t jäns teve tenskap 2 Innehållsförteckning 1. Inledning: bakgrund, syfte och
https://www.ses.lu.se/sites/ses.lu.se/files/he5llbara_livsstilar_och_h-1.pdf - 2026-10-15
Dubbla tragedier – om att låta en litterär slitning förvandla ett dramatiskt skrivande Annika Nyman Huvudhandledare: Sven Bjerstedt Bihandledare: Maja Zade, Sofie Lebech Institution: Teaterhögskolan i Malmö 75%-seminarium, 18 mars 2022 Opponent: Laura Luise Schultz 1 1 Innehållsförteckning 1 Innehållsförteckning 2 2 Bakgrund, syfte och frågeställningar 6 2.1 Bakgrund 6 2.1.1 Peter Szondi och drama
https://www.thm.lu.se/sites/thm.lu.se/files/2022-03/Annika%20Nyman%2075%25-material.pdf - 2026-10-15
Kommunikation i naturvetenskaplig utbildning RAPPORT | EQ11-PROJEKT | LUNDS UNIVERSITET SUSANNE PELGER & SARA SANTESSON 3KOMMUNIKATION I NATURVETENSKAPLIG UTBILDNING Förord Denna rapport är resultatet av EQ11-projektet Kommunikation i Naturvetenskaplig Utbildning (KomNU), som har genomförts vid Lunds universitets naturvetenskapliga fakultet. Det är många personer som har bidragit till att göra Kom
https://www.naturvetenskap.lu.se/sites/naturvetenskap.lu.se/files/2021-05/Komnu-utan-appendix.pdf - 2026-10-15
Masteruppsats i offentlig förvaltning [VT13] Förvaltningshögskolan, Göteborgs universitet Karin Rhodin Handledare: Patrik Zapata Examinator: Stig Montin Samverkan och avfallsminimering 2 Innehåll 1. Inledning ............................................................................................................................. 3 1.1 Samverkan .................................................
https://www.ses.lu.se/sites/ses.lu.se/files/c_uppsats_spa_rhodin_vt13.pdf - 2026-10-15
Microsoft Word - Rapport.doc Master’s Dissertation Structural Mechanics HÅKAN HALLBERG UTVECKLING AV MODELLER FÖR DYNAMISKA SVARSFUNKTIONER I TURBINROTORER Detta är en tom sida! Copyright © 2003 by Structural Mechanics, LTH, Sweden. Printed by KFS I Lund AB, Lund, Sweden, December 2003 For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5123.pdf - 2026-09-22
