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BACKGROUND: Since the "War on Cancer" was declared in 1971, the United States alone has expended some $300 billion on research, with a heavy focus on the role of genomics in anticancer therapy. Voluminous data have been collected and analyzed. However, in hindsight, any achievements made have not been realized in clinical practice in terms of overall survival or quality of life extended. This migh
Control of crop pests by shifting host plant availability and natural enemy activity at landscape scales has great potential to enhance the sustainability of agriculture. However, mainstreaming natural pest control requires improved understanding of how its benefits can be realized across a variety of agroecological contexts. Empirical studies suggest significant but highly variable responses of n
Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is more challenging. In this study, we manually curated 1235 SVs, which can ultimately be used to evaluate SV callers or train machine learning models. We deve
Porcine sapovirus is an enteric calicivirus in domestic pigs that belongs to the family Caliciviridae. Some porcine sapoviruses are genetically related to human caliciviruses, which has raised public health concerns over animal reservoirs and the potential cross-species transmission of sapoviruses. We report on the incidence, genetic diversity, and molecular epidemiology of sapoviruses detected in
To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced these genes in diagnostic samples from 515 patients (227 AMLs and 288 ALLs). Somatic IDH1/IDH2 mutations were rare in ALL (N=1), but were more common in AML, occurring in 3.5% (IDH1 N=3 and IDH2 N=5), with the frequency h
Background: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. Methods: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calciu
Background: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma. Objective: We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 inoculation in healthy subjects and asthmatic patients. Methods: In this double-bl
Floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis is a complex and coordinate cellular process executed by petal limb cells of a Petunia×hybrida cv. 'Mitchell Diploid' (MD) plant. In MD flowers, the majority of benzenoid volatile compounds are derived from a core phenylpropanoid pathway intermediate by a coenzyme A (CoA) dependent, β-oxidative scheme. Metabolic flux analysis, reverse g
Sinus tachycardia (ST) is ubiquitous, but its presence outside of normal physiological triggers in otherwise healthy individuals remains a commonly encountered phenomenon in medical practice. In many cases, ST can be readily explained by a current medical condition that precipitates an increase in the sinus rate, but ST at rest without physiological triggers may also represent a spectrum of normal
Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves candidates for causality, but simply act as markers for functional variants. By means of imputation
Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and polyfluoroalkyl substances (PFAS). However, research on the extent of these co-exposures and their combined effects remains limited. The objective of this study
Home oxygen therapy is a well-accepted treatment for advanced respiratory disease; however, there are substantial evidence gaps and implementation challenges. The patient experience varies widely; oxygen therapy devices are often poorly matched to patient needs; and adherence is suboptimal. Recent clinical trials have failed to demonstrate positive outcomes of home oxygen therapy across a range of
Microsoft Word - 2018-10-29 VP o RF 2019 1 Verksamhetsplan och resursfördelning 2019 PLANERINGSFÖRUTSÄTTNINGAR FÖR 2020 och 2021 LUNDS UNIVERSITET | DNR STYR 2018/16 | BESLUT 2018-10-26 2 3 Beslut Verksamhetsplanen utgår från universitetets strategiska plan, den årliga riskanalysen, omvärldsanalysen och andra centrala styrdokument. Verksamhetsplanen beskriver universitetets målsättningar, priorite
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/verksamhetsplan-och-resursfordelning-2019.pdf - 2026-08-22
5003 Dynamisk simulering för att förbättra hanteringen av järnvägsstörningar Ove Hagelstedt Division of Risk Management and Societal Safety Lund University, Sweden Riskhantering och samhällssäkerhet Lunds tekniska högskola Lunds universitet Report 5003, Lund 2015 II III Dynamisk simulering för att förbättra hanteringen av järnvägsstör
https://www.cencip.lu.se/sites/cencip.lu.se/files/hagelstedt_2015.pdf - 2026-08-22
workreport SASNET Work Report (Verksamhetsberättelse) 1 januari – 31 december 2015 Swedish South Asian Studies Network (SASNET) at Lund University (Nätverket för Sydasienstudier i Sverige) Box 114, 221 00 Lund http://www.sasnet.lu.se Administrativ rapport No. 16 Lund 29 Februari 2016 Sammanställd av: Anna Lindberg, föreståndare/koordinator Lars Eklund, bitr. föreståndare/forskningskommunikatör Inn
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/workreport2015complete.pdf - 2026-08-22
Oärliga handledare lurar doktorander Centrumbildningar flyttar till fakulteter Eksem speglar trender Sverige idag LUNDS UNIVERSITETS MAGASIN | NR 1 | 2017 FÖREDÖME ELLER SKRÄCKEXEMPEL? 2 LUM NR 1 | 2017 LUM NR 1 | 2017 3 Med fulla hus på samtliga arrange mang finns det anledning för en ordförande i universitetets jubi leumskommitté att vara nöjd. – Det har varit en enastående start på jubileet m
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-1-2017.pdf - 2026-08-22
Lunds Tekniska Högskola Matematik Helsingborg Lösningar, FMSF40 Sannolikhetsteori och Diskret Matematik 2024-04-03 1. a) Om ξ betecknar antallet bl̊a kaniner gäller ξ ∈ Hyp(15, 5, 6/15). Vi har d̊a P (A) = P (ξ ≥ 2) = 1− P (ξ ≤ 1) = 1− ( P (ξ = 0) + P (ξ = 1) ) = 1− (( 6 0 )( 9 5 )( 15 5 ) + ( 6 1 )( 9 4 )( 15 5 ) ) = 1− ( 1 · 126 3003 + 6 · 126 3003 ) = 101 143 = 0.706293 Antallet gula kaniner
