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Human immunodeficiency virus type 1-based lentivirus vectors containing the green fluorescent protein (GFP) gene were used to transduce murine Lin(-) c-kit(+) Sca1(+) primitive hematopoietic progenitor cells. Following transduction, the cells were plated into hematopoietic progenitor cell assays in methylcellulose and the colonies were scored for GFP positivity. After incubation for 20 h, lentivir
Osteoarthritis (OA) constitutes a major and increasing burden on patients, health care systems and the broader society. It is estimated that around a quarter of the adult population is affected by OA in the knee and hip and that the prevalence of OA will increase over the coming decades largely due to aging and adverse life-style factors. Prevention and effective care are critical to manage the ch
In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati
Characterization of normal breast stem cells is important for understanding their role in breast development and in breast cancer. However, the identity of these cells is a subject of controversy and their localization in the breast epithelium is not known. In this study, we utilized a novel approach to analyze the morphogenesis of mammary lobules, by combining one-dimensional theoretical models a
Sertoli cells (SCs) provide immune protection and nutritive support to the developing germ cells in the testis. Sertoli cells have also been shown to provide immune protection to islets transplanted outside the testes. In this study, the ability of these cells to diminish the infiltration/activation of microglia into a neural graft implanted in the lesioned striatum of a hemiparkinsonian rat was i
Background: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoid factor (RF), and anti-carbamylated protein antibodies (anti-CarP) often occur together, and it is thus unclear whether smoking is specifically associated with some autoantibodie
Summary: Why do forest productivity and biomass decline with elevation? To address this question, research to date generally has focused on correlative approaches describing changes in woody growth and biomass with elevation. We present a novel, mechanistic approach to this question by quantifying the autotrophic carbon budget in 16 forest plots along a 3300 m elevation transect in Peru. Low growt
BACKGROUND: Protein S is an important regulatory protein of the coagulation cascade. The risk for venous thrombosis associated with protein S deficiency has been uncertain because all previous risk estimates used phenotypic evaluation alone, which can be ambiguous.OBJECTIVE: To quantitate the risk for thrombosis associated with a characterized protein S gene mutation that causes a Gly295-->Val sub
Plants make specialized bioactive metabolites to defend themselves against attackers. The conserved control mechanisms are based on transcriptional activation of the respective plant species-specific biosynthetic pathways by the phytohormone jasmonate. Knowledge of the transcription factors involved, particularly in terpenoid biosynthesis, remains fragmentary. By transcriptome analysis and functio
BACKGROUND: A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear.PATIENTS AND METHODS: Paired normal and tumor DNA was analyzed for BRCA1/2 mutations by massively parallel seque
Genes encoding the DNA helicase TWINKLE (C10orf2) or the two subunits of mtDNA polymerase γ (POLγ) (POLG1 and POLG2) have a direct effect on the mitochondrial DNA replication machinery and were reported in many mitochondrial disorders. Friedreich's ataxia (FRDA) is the common cause of ataxia often associated with the expansion of a GAA repeat in intron 1 of the frataxin gene (FXN). Mitochondrial D
The best current model of breast cancer evolution suggests that most cancers arise from certain premalignant lesions. We have identified a common (34%) somatic mutation in the estrogen receptor (ER)-alpha gene in a series of 59 typical hyperplasias, a type of early premalignant breast lesion. The mutation, which affects the border of the hinge and hormone binding domains of ER-alpha, showed increa
Pufendorfinstitutet 10 år - En resultatuppföljning LUNDS UNIVERSITET 2019 32 32 Förord Pufendorfinstitutet har sedan starten tagit emot 31 Temagrupper och 42 Advanced Study Groups, cirka 700 forskare har därmed varit verksamma vid institutet sedan 2009. I denna rapport presenteras en resultatuppfölj- ning av gruppernas arbete vid institutet. Först redovisas forskarnas egna erfarenheter och värderi
https://www.pi.lu.se/sites/pi.lu.se/files/rapport_pufendorf_10_ar.pdf - 2026-08-14
Verksamhetsplan och resursfördelning 2024 Verksamhetsplan och resursfördelning 2024 Planeringsförutsättningar för 2025 och 2026 LUNDS UNIVERSITET | DNR STYR 2023/82 | BESLUT 2023-10-27 ...................................................................................... ..................................................................................................... ..........................
https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2023-11/Fordelningsbeslut-2025-2026-20231027.pdf - 2026-08-14
Litteraturlista FPRA22 - HT2025 Sida 1 av 2 Filosofiska institutionen LITTERATURLISTA VT2026 FPRA22, Praktisk filosofi, fortsättningskurs, 30 hp Fastställd av Filosofiska institutionens studierektor 2025-11-25 Delkurs 1 – Fördjupad moralfilosofi (7,5 hp) Ross, D: The Right and the Good. Eds (Phillip Stratton-Lake) Oxford: Clarendon Press. 1930/2002. Fisher, Andrew: Metaethics: An Introduction. Acu
https://www.fil.lu.se/media/utbildning/dokument/kurser/FPRA22/20261/Litteraturlista_FPRA22_VT2026.pdf - 2026-07-05
Litteraturlista FTEA21 - VT26 Sida 1 av 2 Filosofiska institutionen LITTERATURLISTA VT2026 FTEA21, Teoretisk filosofi, fortsättningskurs, 30 hp Fastställd av Filosofiska institutionens studierektor 2024-11-25 Delkurs 1 – Kunskapsteori (7,5 hp) Bernecker, Sven & Dretske, Fred I.: Knowledge – Readings in Contemporary Epistemology, Oxford University Press, 2000. Olsson, Erik J: Kunskapsteori. En hist
https://www.fil.lu.se/media/utbildning/dokument/kurser/FTEA21/20261/Litteraturlista_FTEA21_VT2026.pdf - 2026-07-05
1 STYR 2024/3201 Slutrapport Uppdrag att ta fram förslag till sammanhållet arbete i användning av artificiell intelligens med särskilt fokus på utbildningsfrågor 2 1. Sammanfattning och summary ...................................................................... 3 2. Bakgrund ...................................................................................................... 4 3. Uppdatering .
