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The physiology underlying the intracranial pressure (ICP) curve morphology is not fully understood. Recent research has suggested that the morphology could be dependent on arterial cerebral inflow and the physiological and pathophysiological properties of the intracranial cavity. If understood, the ICP curve could provide information about the patient’s cerebrovascular state important in individua
A search is performed for localised excesses in dijet mass distributions of low-dijet-mass events produced in association with a high transverse energy photon. The search uses up to 79.8 fb−1 of LHC proton–proton collisions collected by the ATLAS experiment at a centre-of-mass energy of 13 TeV during 2015–2017. Two variants are presented: one which makes no jet flavour requirements and one which r
Purpose: This study investigated whether living in immigrant dense urban districts (IDUDs) and low-income areas in the city of Malmö predicted 5-year mortality among patients admitted to the emergency department (ED) because of acute respiratory distress. Patients and methods: We randomly selected 184 patients with acute respiratory distress during 2007, visiting the ED at Skåne University Hospita
Erysipelas is a common skin infection causing significant morbidity. At present there are no established procedures for bacteriological sampling. Here we investigate the possibility of using cultures for diagnostic purposes by determining the perianal colonization with beta-hemolytic streptococci (BHS) in patients with erysipelas. Patients with erysipelas and a control group of patients with fever
Itch is a major symptom of skin disease. Yet, until the last thirty years the investigation of itch has been ignored by researchers. One important reason has been the lack of reliable and sensitive measurement. We can only indirectly measure different aspects of itch perception which is performed on several levels of the nervous system. Physiological itch participates in the defence of the organis
The definition of itch as an unpleasant sensation that elicits an urge or desire to scratch describes the close relationship between the feeling and the response. The physiological role of scratching in response to acute itch is to remove harmful agents from the skin. In the short term, mild scratching relieves itching. With more fierce and prolonged scratching in chronic pruritus, the skin become
It has been known for more than 2000 years that several skin diseases improve upon exposure to the sun. However, it was not until the end of the 19th century before Niels R. Finsen started to use sunlight as well as electric light for the treatment of skin tuberculosis.1 He was awarded the Nobel Prize in 1903 “in recognition of his contribution to the treatment of diseases, especially lupus vulgar
Pancreatic cancer is an aggressive malignancy that carries a high mortality rate. A major contributor to the poor outcome is the lack of effective molecular markers. The purpose of this study was to develop protein markers for improved prognostication and noninvasive diagnosis. A mass spectrometry (MS)-based discovery approach was applied to pancreatic cancer tissues and healthy pancreas. In the v
Background: Fatigue is common among people with multiple sclerosis (MS), and significantly influences engagement in occupations. The Managing Fatigue (MF) programme is an evidence-based occupational therapy group-based intervention, utilising self-management science that provides people with tools to manage fatigue. Although the national MS-guidelines in Sweden cite this as best practice, a Swedis
Carbon Fiber Reinforced Polymer (CFRP) has highly abrasive microstructure due to carbon fiber reinforcement and requires the use of tool materials with good resistance to abrasive wear. The paper presents a study of tool wear in drilling operation. Drill bits with uncoated and diamond coated cemented carbide and polycrystalline diamond were tested in drilling PAN-based CFRP samples. Registered thr
Contact stress on the tool has been measured with a split-tool apparatus that has a poor resolution of the stress distribution, and with photoelastic tools that cannot be used with real cutting parameters since the materials are too weak. This paper presents an improved split-tool design allowing continuous stress distribution dataset instead of discreet steps by using a tilted separation plane be
Introduction: Early assessment of hip fracture patients’ cognitive function is important for preventing pre- and postoperative complications. The aim of this study was twofold: (1) to assess prehospital cognitive function in hip fracture patients and establish whether cognitive status differs pre- and postoperatively between prehospital fast track care (PFTC) and the traditional emergency departme
In the 1990s it was discovered that the enzyme dipeptidyl peptidase-4 (DPP-4) inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). DPP-4 inhibition results in raised levels of the two incretin hormones which in turn result in lowering of circulating glucose through stimulation of insulin secretion and inhibition of glucagon secre
Widespread increases in iron (Fe) concentrations are contributing to ongoing browning of northern freshwaters, but the driver/s behind the trends are not known. Fe mobilization in soils is known to be controlled by redox conditions, pH, and DOC availability for complexation. Moreover, high sulfate concentrations have been suggested to constrain Fe in transition from soil to water, and declining su
Multipolar fluorine–amide interactions with backbone and side-chain amides have been described as important for protein–ligand interactions and have been used to improve the potency of synthetic inhibitors. In this study, fluorine interactions within a well-defined binding pocket on galectin-3 were investigated systematically using phenyltriazolyl-thiogalactosides fluorinated singly or multiply at
The increased interest in predatory bacteria due to their ability to kill antibiotic resistant bacteria has also highlighted their inherent plethora of hydrolytic enzymes, and their potential as natural sources of novel therapeutic agents and biotechnological tools. Here, we have identified and characterized a novel protease from the predatory bacterium Bdellovibrio bacteriovorus: BspE (Bdellovibr
