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Gap Distance Between Pearl Chains in Acoustic Manipulation

We present a theory to compute the stable gap (interparticle) distance between particle chains collected in the pressure node of an acoustic standing wave. The primary and secondary acoustic radiation forces are the two competing forces that act on the particles during the particle chain formation. The stable equilibrium distance between two chains is reached when both forces are in balance. Most

Long-run patterns in the discovery of the adjacent possible

The notion of the "adjacent possible" has been advanced to theorize the generation of novelty across many different research domains. This study is an attempt to examine in what way the notion can be made empirically useful for innovation studies. A theoretical framework is construed based on the notion of innovation a search process of recombining knowledge to discover the "adjacent possible". Th

Measurements of the Higgs boson inclusive and differential fiducial cross sections in the 4 ℓ decay channel at √s = 13 TeV

Inclusive and differential fiducial cross sections of the Higgs boson are measured in the H→ ZZ∗→ 4 ℓ (ℓ= e, μ) decay channel. The results are based on proton−proton collision data produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector from 2015 to 2018, equivalent to an integrated luminosity of 139 fb - 1. The inclusive fiducial cross section

The Rise and Fall of Energy Democracy: 5 Cases of Collaborative Governance in Energy Systems

A wide range of actors are seeking to democratize energy systems. In the collaborative governance process of energy system transitions to net zero, however, many energy democracy concepts are watered down or abandoned entirely. Using five renewable energy case studies, we first explore the diversity of energy democratizing system challengers and bottom-up actors. Secondly, we analyze the role of c

Network analysis of sea turtle movements and connectivity: A tool for conservation prioritization

Aim: Understanding the spatial ecology of animal movements is a critical element in conserving long-lived, highly mobile marine species. Analyzing networks developed from movements of six sea turtle species reveals marine connectivity and can help prioritize conservation efforts. Location: Global. Methods: We collated telemetry data from 1235 individuals and reviewed the literature to determine ou

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolutio

Palaeoecological data indicates land-use changes across Europe linked to spatial heterogeneity in mortality during the Black Death pandemic

The Black Death (1347–1352 ce) is the most renowned pandemic in human history, believed by many to have killed half of Europe’s population. However, despite advances in ancient DNA research that conclusively identified the pandemic’s causative agent (bacterium Yersinia pestis), our knowledge of the Black Death remains limited, based primarily on qualitative remarks in medieval written sources avai

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to id

Rare germline copy number variants (CNVs) and breast cancer risk

Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions

Measurement of the c-jet mistagging efficiency in tt¯ events using pp collision data at √s=13 TeV collected with the ATLAS detector

A technique is presented to measure the efficiency with which c-jets are mistagged as b-jets (mistagging efficiency) using tt¯ events, where one of the W bosons decays into an electron or muon and a neutrino and the other decays into a quark–antiquark pair. The measurement utilises the relatively large and known W→ cs branching ratio, which allows a measurement to be made in an inclusive c-jet sam

Measurement of inclusive charged-particle b-jet production in pp and p-Pb collisions at √sNN = 5.02 TeV

A measurement of the inclusive b-jet production cross section is presented in pp and p-Pb collisions at sNN = 5.02 TeV, using data collected with the ALICE detector at the LHC. The jets were reconstructed in the central rapidity region |η| < 0.5 from charged particles using the anti-kT algorithm with resolution parameter R = 0.4. Identification of b jets exploits the long lifetime of b hadrons, us

Operation and performance of the ATLAS semiconductor tracker in LHC Run 2

The semiconductor tracker (SCT) is one of the tracking systems for charged particles in the ATLAS detector. It consists of 4088 silicon strip sensor modules. During Run 2 (2015-2018) the Large Hadron Collider delivered an integrated luminosity of 156 fb−1 to the ATLAS experiment at a centre-of-mass proton-proton collision energy of 13 TeV. The instantaneous luminosity and pile-up conditions were f

Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease

Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for

Effects of an Annular Piston Bowl-Rim Cavity on In-Cylinder and Engine-Out Soot of a Heavy-Duty Optical Diesel Engine

The effect of an annular, piston bowl-rim cavity on in-cylinder and engine-out soot emissions is measured in a heavy-duty, optically accessible, single-cylinder diesel engine using in-cylinder soot diagnostics and exhaust smoke emission measurements. The baseline piston configuration consists of a right-cylindrical bowl, while the cavity-piston configuration features an additional annular cavity t

An Experimental Investigation of Directly Injected E85 Fuel in a Heavy-Duty Compression Ignition Engine

A commercially available fuel, E85, a blend of ~85% ethanol and ~15% gasoline, can be a viable substitute for fossil fuels in internal combustion engines in order to achieve a reduction of the greenhouse gas (GHG) emissions. Ethanol is traditionally made of biomass, which makes it a part of the food-feed-fuel competition. New processes that reuse waste products from other industries have recently

Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

The predictive function of Swedish word accents

Swedish lexical word accents have been repeatedly said to have a low functional load. Even so, the language has kept these tones ever since they emerged probably over a thousand years ago. This article proposes that the primary function of word accents is for listeners to be able to predict upcoming morphological structures and narrow down the lexical competition rather than being lexically distinSwedish lexical word accents have been repeatedly said to have a lowfunctional load. Even so, the language has kept these tones ever sincethey emerged probably over a thousand years ago. This article proposesthat the primary function of word accents is for listeners to be ableto predict upcoming morphological structures and narrow down thelexical competition rather than being lexically distinctive